scholarly journals Germ cells, origin of somatic stem cells?

Cell Research ◽  
2008 ◽  
Vol 18 (S1) ◽  
pp. S26-S26
Author(s):  
Karim Nayernia
Keyword(s):  
Stem Cells ◽  
Germ Cells ◽  
Somatic Stem Cells

scholarly journals Vasa unveils a common origin of germ cells and of somatic stem cells from the posterior growth zone in the polychaete Platynereis dumerilii

2007 ◽  
Vol 306 (2) ◽  
pp. 599-611 ◽  
Author(s):  
N. Rebscher ◽  
F. Zelada-González ◽  
T.U. Banisch ◽  
F. Raible ◽  
D. Arendt
Keyword(s):  
Stem Cells ◽  
Germ Cells ◽  
Growth Zone ◽  
Common Origin ◽  
Somatic Stem Cells ◽  
Posterior Growth Zone ◽  
Platynereis Dumerilii

The germ line regulates somatic cyst cell proliferation and fate during Drosophila spermatogenesis

Development ◽  
1996 ◽  
Vol 122 (8) ◽  
pp. 2437-2447 ◽  
Author(s):  
P. Gonczy ◽  
S. DiNardo
Keyword(s):  
Stem Cells ◽  
Cell Proliferation ◽  
Cell Fate ◽  
Germ Cells ◽  
Germ Line ◽  
Lineage Tracing ◽  
Somatic Stem Cells ◽  
Daughter Cyst ◽  
Cyst Cell ◽  
Cyst Cells

Spermatogenesis relies on the function of germ-line stem cells, as a continuous supply of differentiated spermatids is produced throughout life. In Drosophila, there must also be somatic stem cells that produce the cyst cells that accompany germ cells throughout spermatogenesis. By lineage tracing, we demonstrate the existence of such somatic stem cells and confirm that of germ-line stem cells. The somatic stem cells likely correspond to the ultrastructurally described cyst progenitor cells. The stem cells for both the germ-line and cyst lineage are anchored around the hub of non-dividing somatic cells located at the testis tip. We then address whether germ cells regulate the behavior of somatic hub cells, cyst progenitors and their daughter cyst cells by analyzing cell proliferation and fate in testes in which the germ line has been genetically ablated. Daughter cyst cells, which normally withdraw from the cell cycle, continue to proliferate in the absence of germ cells. In addition, cells from the cyst lineage switch to the hub cell fate. Male-sterile alleles of chickadee and diaphanous, which are deficient in germ cells, exhibit similar cyst cell phenotypes. We conclude that signaling from germ cells regulates the proliferation and fate of cells in the somatic cyst lineage.

scholarly journals Formative pluripotent stem cells show features of epiblast cells poised for gastrulation

Cell Research ◽  
2021 ◽  
Author(s):  
Xiaoxiao Wang ◽  
Yunlong Xiang ◽  
Yang Yu ◽  
Ran Wang ◽  
Yu Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Germ Cells ◽  
Pluripotent Stem Cells ◽  
Primordial Germ Cells ◽  
Embryonic Stem ◽  
Large Set ◽  
Mouse Escs ◽  
Epiblast Stem Cells ◽  
Early Gastrula

AbstractThe pluripotency of mammalian early and late epiblast could be recapitulated by naïve embryonic stem cells (ESCs) and primed epiblast stem cells (EpiSCs), respectively. However, these two states of pluripotency may not be sufficient to reflect the full complexity and developmental potency of the epiblast during mammalian early development. Here we report the establishment of self-renewing formative pluripotent stem cells (fPSCs) which manifest features of epiblast cells poised for gastrulation. fPSCs can be established from different mouse ESCs, pre-/early-gastrula epiblasts and induced PSCs. Similar to pre-/early-gastrula epiblasts, fPSCs show the transcriptomic features of formative pluripotency, which are distinct from naïve ESCs and primed EpiSCs. fPSCs show the unique epigenetic states of E6.5 epiblast, including the super-bivalency of a large set of developmental genes. Just like epiblast cells immediately before gastrulation, fPSCs can efficiently differentiate into three germ layers and primordial germ cells (PGCs) in vitro. Thus, fPSCs highlight the feasibility of using PSCs to explore the development of mammalian epiblast.

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