scholarly journals Optical coherence tomography for the quantitative study of cerebrovascular physiology

2011 ◽  
Vol 31 (6) ◽  
pp. 1339-1345 ◽  
Author(s):  
Vivek J Srinivasan ◽  
Dmitriy N Atochin ◽  
Harsha Radhakrishnan ◽  
James Y Jiang ◽  
Svetlana Ruvinskaya ◽  
...  
Keyword(s):  
Blood Flow ◽  
Optical Coherence Tomography ◽  
Cerebral Blood Flow ◽  
Quantitative Study ◽  
Quantitative Method ◽  
Tissue Perfusion ◽  
Optical Coherence ◽  
Branch Points ◽  
Clearance Flow ◽  
Hydrogen Clearance

Doppler optical coherence tomography (DOCT) and OCT angiography are novel methods to investigate cerebrovascular physiology. In the rodent cortex, DOCT flow displays features characteristic of cerebral blood flow, including conservation along nonbranching vascular segments and at branch points. Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range.

scholarly journals Quantitative cerebral blood flow with Optical Coherence Tomography

2010 ◽  
Vol 18 (3) ◽  
pp. 2477 ◽  
Author(s):  
Vivek J. Srinivasan ◽  
Sava Sakadžić ◽  
Iwona Gorczynska ◽  
Svetlana Ruvinskaya ◽  
Weicheng Wu ◽  
...  
Keyword(s):  
Blood Flow ◽  
Optical Coherence Tomography ◽  
Cerebral Blood Flow ◽  
Optical Coherence

Quantitative Cerebral Blood Flow and Angiography with Optical Coherence Tomography

2010 ◽  
Author(s):  
Vivek J. Srinivasan ◽  
Dmitriy N. Atochin ◽  
James Y. Jiang ◽  
Harsha Radhakrishnan ◽  
Mohammed A. Yaseen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Optical Coherence Tomography ◽  
Cerebral Blood Flow ◽  
Optical Coherence

Blood Vessel Density Measured Using Dynamic Optical Coherence Tomography is a Tool for Wound Healers

2021 ◽  
pp. 153473462110173
Author(s):  
Rajgopal Mani ◽  
Jon Holmes ◽  
Kittipan Rerkasem ◽  
Nikolaos Papanas
Keyword(s):  
Blood Flow ◽  
Optical Coherence Tomography ◽  
Blood Vessel ◽  
Chronic Wounds ◽  
Vessel Density ◽  
Optical Coherence ◽  
Skin Microcirculation ◽  
Wound Edge ◽  
Venous Ulcers ◽  
Oct Imaging

Dynamic optical coherence tomography (D-OCT) is a relatively new technique that may be used to study the substructures in the retina, in the skin and its microcirculation. Furthermore, D-OCT is a validated method of imaging blood flow in skin microcirculation. The skin around venous and mixed arterio-venous ulcers was imaged and found to have tortuous vessels assumed to be angiogenic sprouts, and classified as dots, blobs, coils, clumps, lines, and curves. When these images were analyzed and measurements of vessel density were made, it was observed that the prevalence of coils and clumps in wound borders was significantly greater compared with those at wound centers. This reinforced the belief of inward growth of vessels from wound edge toward wound center which, in turn, reposed confidence in following the wound edge to study healing. D-OCT imaging permits the structure and the function of the microcirculation to be imaged, and vessel density measured. This offers a new vista of skin microcirculation and using it, to better understand angiogenesis in chronic wounds.

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