scholarly journals Noninvasive Real-Time Visualization of Multiple Cerebral Hemodynamic Parameters in Whole Mouse Brains Using Five-Dimensional Optoacoustic Tomography

2015 ◽  
Vol 35 (4) ◽  
pp. 531-535 ◽  
Author(s):  
Sven Gottschalk ◽  
Thomas Felix Fehm ◽  
Xosé Luís Deán-Ben ◽  
Daniel Razansky
Keyword(s):  
Real Time ◽  
Cerebral Blood Volume ◽  
Functional Neuroimaging ◽  
Three Dimensional ◽  
Blood Oxygenation ◽  
Hemodynamic Parameters ◽  
Label Free ◽  
Optoacoustic Tomography ◽  
Real Time Visualization ◽  
Tomographic Data

Current functional neuroimaging methods are not adequate for high-resolution whole-brain visualization of neural activity in real time. Here, we show imaging of fast hemodynamic changes in deep mouse brain using fully noninvasive acquisition of five-dimensional optoacoustic data from animals subjected to oxygenation stress. Multispectral video-rate acquisition of three-dimensional tomographic data enables simultaneous label-free assessment of multiple brain hemodynamic parameters, including blood oxygenation, total hemoglobin, cerebral blood volume, oxygenized and deoxygenized hemoglobin, in real time. The unprecedented results indicate that the proposed methodology may serve as a powerful complementary, and potentially superior, method for functional neuroimaging studies in rodents.

Laser system for real-time visualization of three-dimensional objects

1998 ◽  
Author(s):  
Vladimir V. Savelyev ◽  
Peter E. Tverdokhleb ◽  
Anatoly V. Trubetskoy ◽  
Yury A. Shchepetkin
Keyword(s):  
Real Time ◽  
Laser System ◽  
Three Dimensional ◽  
Three Dimensional Objects ◽  
Real Time Visualization

Simultaneous visualization of tumour oxygenation, neovascularization and contrast agent perfusion by real-time three-dimensional optoacoustic tomography

2015 ◽  
Vol 26 (6) ◽  
pp. 1843-1851 ◽  
Author(s):  
Vladimir Ermolayev ◽  
Xose Luis Dean-Ben ◽  
Subhamoy Mandal ◽  
Vasilis Ntziachristos ◽  
Daniel Razansky
Keyword(s):  
Contrast Agent ◽  
Real Time ◽  
Three Dimensional ◽  
Optoacoustic Tomography ◽  
Tumour Oxygenation ◽  
Simultaneous Visualization

scholarly journals Bedside 3D Visualization of Lymphatic Vessels with a Handheld Multispectral Optoacoustic Tomography Device

2020 ◽  
Vol 9 (3) ◽  
pp. 815 ◽  
Author(s):  
Guido Giacalone ◽  
Takumi Yamamoto ◽  
Florence Belva ◽  
Akitatsu Hayashi
Keyword(s):  
Real Time ◽  
Near Infrared ◽  
3D Visualization ◽  
Imaging Modality ◽  
Three Dimensional ◽  
Lymphatic Vessels ◽  
Secondary Lymphedema ◽  
Optoacoustic Tomography ◽  
Small Vessels ◽  
Promising Tool

Identification of lymphatics by Indocyanine Green (ICG) lymphography in patients with severe lymphedema is limited due to the overlying dermal backflow. Nor can the method detect deep and/or small vessels. Multispectral optoacoustic tomography (MSOT), a real-time three- dimensional (3D) imaging modality which allows exact spatial identification of absorbers in tissue such as blood and injected dyes can overcome these hurdles. However, MSOT with a handheld probe has not been performed yet in lymphedema patients. We conducted a pilot study in 11 patients with primary and secondary lymphedema to test whether lymphatic vessels could be detected with a handheld MSOT device. In eight patients, we could not only identify lymphatics and veins but also visualize their position and contractility. Furthermore, deep lymphatic vessels not traceable by ICG lymphography and lymphatics covered by severe dermal backflow, could be clearly identified by MSOT. In three patients, two of which had advanced stage lymphedema, only veins but no lymphatic vessels could be identified. We found that MSOT can identify and image lymphatics and veins in real-time and beyond the limits of near-infrared technology during a single bedside examination. Given its easy use and high accuracy, the handheld MSOT device is a promising tool in lymphatic surgery.

Three-dimensional quantitative functional optoacoustic tomography to estimate vascular blood oxygenation of the breast

2021 ◽  
Author(s):  
Seonyeong Park ◽  
Umberto Villa ◽  
Frank J. Brooks ◽  
Richard Su ◽  
Alexander A. Oraevsky ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Blood Oxygenation ◽  
Optoacoustic Tomography

scholarly journals Real-time three-dimensional histology-like imaging by label-free nonlinear optical microscopy

2020 ◽  
Vol 10 (11) ◽  
pp. 2177-2190
Author(s):  
Yi Sun ◽  
Sixian You ◽  
Xiaoxi Du ◽  
Allison Spaulding ◽  
Z. George Liu ◽  
...  
Keyword(s):  
Optical Microscopy ◽  
Real Time ◽  
Nonlinear Optical ◽  
Three Dimensional ◽  
Label Free ◽  
Nonlinear Optical Microscopy

scholarly journals An IoT System for Remote Health Monitoring in Elderly Adults through a Wearable Device and Mobile Application

Geriatrics ◽  
2019 ◽  
Vol 4 (2) ◽  
pp. 34 ◽  
Author(s):  
Luis A. Durán-Vega ◽  
Pedro C. Santana-Mancilla ◽  
Raymundo Buenrostro-Mariscal ◽  
Juan Contreras-Castillo ◽  
Luis E. Anido-Rifón ◽  
...  
Keyword(s):  
Real Time ◽  
Health Monitoring ◽  
Mobile Application ◽  
Blood Oxygenation ◽  
Elderly Adults ◽  
Health Monitoring System ◽  
Proposal A ◽  
Real Time Visualization ◽  
Remote Health

With the increase in global life expectancy and the advance of technology, the creation of age-friendly environments is a priority in the design of new products for elderly people healthcare. This paper presents a proposal for a real-time health monitoring system of older adults living in geriatric residences. This system was developed to help caregivers to have a better control in monitoring the health of their patients and have closer communication with their patients’ family members. To validate the feasibility and effectiveness of this proposal, a prototype was built, using a biometric bracelet connected to a mobile application, which allows real-time visualization of all the information generated by the sensors (heart rate, body temperature, and blood oxygenation) in the bracelet. Using these data, caregivers can make decisions about the health status of their patients. The evaluation found that the users perceived the system to be easy to learn and use, providing initial evidence that our proposal could improve the quality of the adult’s healthcare.

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