scholarly journals Phosphohistone H3 expression has much stronger prognostic value than classical prognosticators in invasive lymph node-negative breast cancer patients less than 55 years of age

2007 ◽  
Vol 20 (12) ◽  
pp. 1307-1315 ◽  
Author(s):  
Ivar Skaland ◽  
Emiel A M Janssen ◽  
Einar Gudlaugsson ◽  
Jan Klos ◽  
Kjell H Kjellevold ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Prognostic Value ◽  
Breast Cancer Patients ◽  
Node Negative ◽  
Node Negative Breast Cancer ◽  
Phosphohistone H3

Prognostic value of proliferating cell nuclear antigen in lymph node—negative breast cancer patients

Cancer ◽  
1993 ◽  
Vol 72 (1) ◽  
pp. 120-125 ◽  
Author(s):  
Simonetta Bianchi ◽  
Milena Paglierani ◽  
Giancarlo Zampi ◽  
Gaetano Cardona ◽  
Luigi Cataliotti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Proliferating Cell Nuclear Antigen ◽  
Prognostic Value ◽  
Nuclear Antigen ◽  
Breast Cancer Patients ◽  
Node Negative ◽  
Node Negative Breast Cancer ◽  
Proliferating Cell

The prognostic value of proliferation in lymph-node-negative breast cancer patients is age dependent

2007 ◽  
Vol 43 (3) ◽  
pp. 527-535 ◽  
Author(s):  
Jan P.A. Baak ◽  
Paul J. van Diest ◽  
Feja J. Voorhorst ◽  
Elsken van der Wall ◽  
Louk V.A.M. Beex ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Prognostic Value ◽  
Breast Cancer Patients ◽  
Node Negative ◽  
Node Negative Breast Cancer ◽  
Age Dependent

scholarly journals LOH at 1p31 (ARHI) and Proliferation in Lymph Node-Negative Breast Cancer

2009 ◽  
Vol 31 (5) ◽  
pp. 335-343
Author(s):  
Emiel A. M. Janssen ◽  
Irene T. Øvestad ◽  
Ivar Skaland ◽  
Håvard Søiland ◽  
Einar Gudlaugsson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Adjuvant Chemotherapy ◽  
Cancer Patients ◽  
Activity Index ◽  
Breast Cancer Patients ◽  
Node Negative ◽  
Node Negative Breast Cancer ◽  
Phosphohistone H3 ◽  
Mitotic Activity Index

Background: The mitotic activity index (MAI) is a strong prognosticator in node-negative invasive breast cancer patients. Recently, a correlation between the MAI and specific chromosomal aberrations at chromosome 1p was described.Methods: Analysis of MAI, immunohistochemical staining patterns for proliferation-associated phosphohistone H3 (PPH3), phosphorylated ERK1/2, p21, cyclin E, Ki67 and cyclin D1 proteins; and prognosis in 158 adjuvant chemotherapy-treated T1-2N0M0 invasive breast cancer patients, analysis of LOH at 1p31 (including ARHI) using the dinucleotide repeats D1S207, D1S430 and D1S464 in 76 patients. Single and multivariate survival analysis was used to evaluate the importance of the various markers tested.Results: LOH at 1p31 did not correlate with MAI nor provide prognostic information. Phosphohistone H3 was the best prognosticator for patients in all age groups with 20 year distant metastasis free survival of distant metastases 93% vs. 72% respectively (p = 0.004, HR = 4.5). In multivariate analysis, phosphohistone H3 < 13 vs. ≥13 exceeded the prognostic value of the mitotic activity index.Conclusions: LOH at 1p31 is common in breast cancer, and correlates with loss of proliferation-associated proteins, but not with MAI, PPH3 or prognosis. PPH3 is the best prognosticator in this study group of adjuvant chemotherapy-treated lymph node-negative breast cancer patients.

Number of lymph nodes removed in sentinel lymph node-negative breast cancer patients is significantly related to patient age and tumor size

Cancer ◽  
2010 ◽  
Vol 116 (8) ◽  
pp. 1987-1991 ◽  
Author(s):  
Elisa Rush Port ◽  
Sujata Patil ◽  
Michelle Stempel ◽  
Monica Morrow ◽  
Hiram S. Cody
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Tumor Size ◽  
Breast Cancer Patients ◽  
Patient Age ◽  
Node Negative ◽  
Node Negative Breast Cancer

scholarly journals Prognostic significance of uPA/PAI-1 level, HER2 status, and traditional histologic factors for survival in node-negative breast cancer patients

2016 ◽  
Vol 51 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Nina Fokter Dovnik ◽  
Iztok Takac
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Prognostic Value ◽  
Multivariate Model ◽  
Her2 Status ◽  
Breast Cancer Patients ◽  
Node Negative ◽  
Node Negative Breast Cancer ◽  
Size Grade ◽  
Pai 1

Abstract Background The association of HER2 status with urokinase plasminogen activator (uPA) and plasminogen activator inhibitor 1 (PAI-1) levels raises the question whether uPA/PAI-1 level carries additional clinically relevant prognostic information independently from HER2 status. The aim of our study was to compare the prognostic value of uPA/PAI-1 level, HER2 status, and traditional prognostic factors for survival in node-negative breast cancer patients. Patients and methods A retrospective analysis of 858 node-negative breast cancer patients treated in Maribor University Clinical Center, Slovenia, in the years 2000–2009 was performed. Data were obtained from patient medical records. The median follow-up time was 100 months. Univariate and multivariate analyses of disease-free (DFS) and overall survival (OS) were performed using the Cox regression and the Cox proportional hazards model. Results In univariate analysis, age, tumor size, grade, lymphovascular invasion, HER2 status and UPA/PAI-1 level were associated with DFS, and age, tumor size, grade, and uPA/PAI-1 level were associated with OS. In the multivariate model, the most important determinants of DFS were age, estrogen receptor status and uPA/PAI-1 level, and the most important factors for OS were patient age and tumor grade. The HR for death from any cause in the multivariate model was 1.98 (95% CI 0.83–4.76) for patients with high uPA and/or PAI-1 compared to patients with both values low. Conclusions uPA/PAI-1 level clearly carries an independent prognostic value regardless of HER2 status in node-negative breast cancer and could be used in addition to HER2 and other markers to guide clinical decisions in this setting.

scholarly journals Which Cyclin E Prevails as Prognostic Marker for Breast Cancer? Results from a Retrospective Study Involving 635 Lymph Node–Negative Breast Cancer Patients

2006 ◽  
Vol 12 (11) ◽  
pp. 3319-3328 ◽  
Author(s):  
Anieta M. Sieuwerts ◽  
Maxime P. Look ◽  
Marion E. Meijer-van Gelder ◽  
Mieke Timmermans ◽  
Anita M.A.C. Trapman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Retrospective Study ◽  
Cancer Patients ◽  
Prognostic Marker ◽  
Cyclin E ◽  
Breast Cancer Patients ◽  
Node Negative ◽  
Node Negative Breast Cancer
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