scholarly journals R88-APOBEC3Gm Inhibits the Replication of Both Drug-resistant Strains of HIV-1 and Viruses Produced From Latently Infected Cells

2014 ◽  
Vol 3 ◽  
pp. e151 ◽  
Author(s):  
Xiaoxia Wang ◽  
Zhujun Ao ◽  
Kallesh Danappa Jayappa ◽  
Bei Shi ◽  
Gary Kobinger ◽  
...  
Keyword(s):  
Drug Resistant ◽  
Latently Infected ◽  
Infected Cells ◽  
Resistant Strains ◽  
Drug Resistant Strains ◽  
Hiv 1

Rates of transmission of antiretroviral drug resistant strains of HIV-1

2003 ◽  
Vol 26 (2) ◽  
pp. 153-161 ◽  
Author(s):  
Palanee Ammaranond ◽  
Philip Cunningham ◽  
Robert Oelrichs ◽  
Kazuo Suzuki ◽  
Claire Harris ◽  
...  
Keyword(s):  
Drug Resistant ◽  
Antiretroviral Drug ◽  
Resistant Strains ◽  
Drug Resistant Strains ◽  
Hiv 1

Low rate of genotypic HIV-1 drug-resistant strains in the Senegalese government initiative of access to antiretroviral therapy

AIDS ◽  
2003 ◽  
Vol 17 ◽  
pp. S31-S38 ◽  
Author(s):  
Laurence Vergne ◽  
Coumba Touré Kane ◽  
Christian Laurent ◽  
Ndella Diakhaté ◽  
Ndeye Fatou Ngom Gueye ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Drug Resistant ◽  
Resistant Strains ◽  
Government Initiative ◽  
Drug Resistant Strains ◽  
Hiv 1 ◽  
Low Rate

Evaluation of 4-thiazolidinone derivatives as potential reverse transcriptase inhibitors against HIV-1 drug resistant strains

2017 ◽  
Vol 71 ◽  
pp. 211-218 ◽  
Author(s):  
Rahul Suryawanshi ◽  
Sushama Jadhav ◽  
Nandini Makwana ◽  
Dipen Desai ◽  
Devidas Chaturbhuj ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Drug Resistant ◽  
Reverse Transcriptase Inhibitors ◽  
Resistant Strains ◽  
Drug Resistant Strains ◽  
Hiv 1

Synthesis and evaluation of potent human immunodeficiency virus 1 protease inhibitors with epimeric isopropanol as novel P1′ ligands

2020 ◽  
Vol 12 (9) ◽  
pp. 775-794 ◽  
Author(s):  
Mei Zhu ◽  
Ling Ma ◽  
Biao Dong ◽  
Guoning Zhang ◽  
Juxian Wang ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Design Strategy ◽  
Drug Resistant ◽  
Inhibition Activity ◽  
Protease Enzyme ◽  
Immunodeficiency Virus ◽  
Resistant Strains ◽  
Backbone Atoms ◽  
Drug Resistant Strains ◽  
Hiv 1

Aim: HIV-1 protease inhibitors regimens suffered from a number of drawbacks, among which, the most egregious issue was the growing emergence of drug-resistant strains. Materials & methods: The design strategy of maximizing the protease active site interactions with the inhibitor, especially promoting extensive hydrogen bonding with the protein backbone atoms, might be in favor of combating drug resistance. A series of HIV-1 protease inhibitors that incorporated enantiomeric isopropanols as the P1′ ligands in combination with phenols as the P2 ligands were reported herein. Results: A number of inhibitors displayed potent protease enzyme inhibition activity. In particular, inhibitor 14c showed comparable potency as darunavir with IC50 value of 1.91 nM and activity against darunavir-resistant HIV-1 variants. Conclusion: The new kind of HIV-1 protease inhibitors deserves further study.

scholarly journals Cellular HIV-1 DNA Levels in Drug Sensitive Strains Are Equivalent to Those in Drug Resistant Strains in Newly-Diagnosed Patients in Europe

PLoS ONE ◽  
2010 ◽  
Vol 5 (6) ◽  
pp. e10976 ◽  
Author(s):  
Victoria L. Demetriou ◽  
David A. M. C. van de Vijver ◽  
Ioanna Kousiappa ◽  
Claudia Balotta ◽  
Bonaventura Clotet ◽  
...  
Keyword(s):  
Drug Resistant ◽  
Newly Diagnosed ◽  
Resistant Strains ◽  
Drug Resistant Strains ◽  
Hiv 1
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