scholarly journals A cistrome roadmap for understanding pancreatic islet biology

2014 ◽  
Vol 46 (2) ◽  
pp. 95-96
Author(s):  
Dana Avrahami ◽  
Klaus H Kaestner
Keyword(s):  
Pancreatic Islet ◽  
Pancreatic Islet Biology

Pancreatic Islet Biology

2016 ◽  
Keyword(s):  
Pancreatic Islet ◽  
Pancreatic Islet Biology

miR-24 regulates menin in the endocrine pancreas

2014 ◽  
Vol 307 (1) ◽  
pp. E84-E92 ◽  
Author(s):  
Jyothi Vijayaraghavan ◽  
Elaine C. Maggi ◽  
Judy S. Crabtree
Keyword(s):  
Pancreatic Islet ◽  
Feedback Regulation ◽  
Endocrine Tumor ◽  
Causative Role ◽  
Β Cells ◽  
Men1 Gene ◽  
Insulinoma Cells ◽  
Cell Cycle Inhibitors ◽  
Pancreatic Islet Biology

Menin, the product of the MEN1 gene, functions as a tumor suppressor and was first identified in 1997 due to its causative role in the endocrine tumor disorder multiple endocrine neoplasia, type 1 (MEN1). More recently, menin has been identified as a key player in pancreatic islet biology with the observation of an inverse relationship between menin levels and pancreatic islet proliferation. However, the factors regulating menin and the MEN1 gene in the pancreas are poorly understood. Here, we describe the regulation of menin by miR-24 and demonstrate that miR-24 directly decreases menin levels and impacts downstream cell cycle inhibitors in MIN6 insulinoma cells and in βlox5 immortalized β-cells. This regulation of menin impacts cell viability and proliferation in βlox5 cells. Furthermore, our data show a feedback regulation between miR-24 and menin that is present in the pancreas, suggesting that miR-24 regulates menin levels in the pancreatic islet.

scholarly journals Zinc in Pancreatic Islet Biology, Insulin Sensitivity, and Diabetes

2017 ◽  
Vol 22 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Wolfgang Maret
Keyword(s):  
Insulin Sensitivity ◽  
Pancreatic Islet ◽  
Pancreatic Islet Biology

scholarly journals Unraveling pancreatic islet biology by quantitative proteomics

2011 ◽  
Vol 8 (4) ◽  
pp. 495-504 ◽  
Author(s):  
Jian-Ying Zhou ◽  
Geoffrey P Dann ◽  
Chong Wee Liew ◽  
Richard D Smith ◽  
Rohit N Kulkarni ◽  
...  
Keyword(s):  
Pancreatic Islet ◽  
Quantitative Proteomics ◽  
Pancreatic Islet Biology

scholarly journals Histochemical Insights into Pancreatic Islet Biology

2015 ◽  
Vol 63 (8) ◽  
pp. 541-542
Author(s):  
Rebecca L. Hull ◽  
Denis G. Baskin
Keyword(s):  
Pancreatic Islet ◽  
Pancreatic Islet Biology

scholarly journals Sex differences underlying pancreatic islet biology and its dysfunction

2018 ◽  
Vol 15 ◽  
pp. 82-91 ◽  
Author(s):  
Maureen Gannon ◽  
Rohit N. Kulkarni ◽  
Hubert M. Tse ◽  
Franck Mauvais-Jarvis
Keyword(s):  
Sex Differences ◽  
Pancreatic Islet ◽  
Pancreatic Islet Biology

Silver Staining of Pancreatic Islets as Revealed by Electron Microscopy

1967 ◽  
Vol 25 ◽  
pp. 44-45
Author(s):  
Kazuaki Misugi ◽  
Nobuko Misugi ◽  
Hiroshi Yamada
Keyword(s):  
Pancreatic Islet ◽  
Silver Staining ◽  
Islet Cells ◽  
Severe Hypoglycemia ◽  
Granular Cell ◽  
Electron Microscopic Level ◽  
Staining Reaction ◽  
Electron Microscopic ◽  
Pancreatic Islet Cell ◽  
D Cell

The authors had described the fine structure of a type of pancreatic islet cell, which appeared different from typical alpha and beta cells, and tentatively considered that this third type of granular cell probably represents the D cell (Figure 1).Since silver staining has been widely used to differentiate different types of pancreatic islet cells by light microscopy, an attempt to examine this staining reaction at the electron microscopic level was made.Material and Method: Surgically removed specimens from three infants who suffered from severe hypoglycemia were used. The specimens were fixed and preserved in 20% neutral formalin. Frozen sections, 30 to 40 micron thick, were prepared and they were stained by Bielschowsky's method as modified by Suzuki (2). The stained sections were examined under a microscope and islet tissues were isolated. They were fixed in 1% osmium tetroxide in phosphate buffer for one hour and embedded in Epon 812 following dehydration through a series of alcohols and propylene oxide.

Ameliorative Effect of Methyl 2-(4'-Methoxy-4'-oxobutanamide) Benzoate on Insulin-induced Pancreatic Islet Damage in Zebrafish

2017 ◽  
Author(s):  
Y Jeon ◽  
H Nam Youn ◽  
H Kang Tong ◽  
H Kwak Jong
Keyword(s):  
Pancreatic Islet ◽  
Ameliorative Effect

Human pancreatic islet-derived precursor cells display mesenchymal stem cell features and differentiation capacity

2007 ◽  
Vol 2 (S 1) ◽  
Author(s):  
C Limbert ◽  
G Päth ◽  
F Jakob ◽  
X Niu ◽  
R Ebert ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Pancreatic Islet ◽  
Precursor Cells ◽  
Differentiation Capacity ◽  
Human Pancreatic Islet
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