scholarly journals Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population

2011 ◽  
Vol 43 (10) ◽  
pp. 1001-1004 ◽  
Author(s):  
Satoshi Arakawa ◽  
Atsushi Takahashi ◽  
Kyota Ashikawa ◽  
Naoya Hosono ◽  
Tomomi Aoi ◽  
...  
Keyword(s):  
Association Study ◽  
Macular Degeneration ◽  
Japanese Population ◽  
Genome Wide Association Study ◽  
Age Related Macular Degeneration ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Age Related ◽  
Genome Wide

scholarly journals A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

2015 ◽  
Vol 48 (2) ◽  
pp. 134-143 ◽  
Author(s):  
Lars G Fritsche ◽  
Wilmar Igl ◽  
Jessica N Cooke Bailey ◽  
Felix Grassmann ◽  
Sebanti Sengupta ◽  
...  
Keyword(s):  
Association Study ◽  
Macular Degeneration ◽  
Genome Wide Association Study ◽  
Age Related Macular Degeneration ◽  
Genome Wide Association ◽  
Common Variants ◽  
Large Genome ◽  
Age Related ◽  
Genome Wide

Genome-wide association study suggests four variants influencing outcomes with ranibizumab therapy in exudative age-related macular degeneration

2018 ◽  
Vol 63 (10) ◽  
pp. 1083-1091 ◽  
Author(s):  
Masato Akiyama ◽  
Atsushi Takahashi ◽  
Yukihide Momozawa ◽  
Satoshi Arakawa ◽  
Fuyuki Miya ◽  
...  
Keyword(s):  
Association Study ◽  
Macular Degeneration ◽  
Genome Wide Association Study ◽  
Age Related Macular Degeneration ◽  
Genome Wide Association ◽  
Age Related ◽  
Genome Wide

Genome-wide association study of neovascular age-related macular degeneration in the Thai population

2017 ◽  
Vol 62 (11) ◽  
pp. 957-962 ◽  
Author(s):  
Paisan Ruamviboonsuk ◽  
Mongkol Tadarati ◽  
Panisa Singhanetr ◽  
Sukanya Wattanapokayakit ◽  
Punna Kunhapan ◽  
...  
Keyword(s):  
Association Study ◽  
Macular Degeneration ◽  
Genome Wide Association Study ◽  
Age Related Macular Degeneration ◽  
Genome Wide Association ◽  
Thai Population ◽  
Age Related ◽  
Genome Wide

scholarly journals Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases

2020 ◽  
Vol 52 (7) ◽  
pp. 669-679 ◽  
Author(s):  
Kazuyoshi Ishigaki ◽  
Masato Akiyama ◽  
Masahiro Kanai ◽  
Atsushi Takahashi ◽  
Eiryo Kawakami ◽  
...  
Keyword(s):  
Association Study ◽  
Japanese Population ◽  
Large Scale ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Genome Wide

scholarly journals Genome-wide association analyses identify two susceptibility loci for pachychoroid disease central serous chorioretinopathy

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Yoshikatsu Hosoda ◽  
Masahiro Miyake ◽  
Rosa L. Schellevis ◽  
Camiel J. F. Boon ◽  
Carel B. Hoyng ◽  
...  
Keyword(s):  
Odds Ratio ◽  
Central Serous Chorioretinopathy ◽  
Genome Wide Association Study ◽  
Risk Allele ◽  
Age Related Macular Degeneration ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Association Analyses ◽  
Age Related ◽  
Genome Wide

AbstractThe recently emerged pachychoroid concept has changed the understanding of age-related macular degeneration (AMD), which is a major cause of blindness; recent studies attributed AMD in part to pachychoroid disease central serous chorioretinopathy (CSC), suggesting the importance of elucidating the CSC pathogenesis. Our large genome-wide association study followed by validation studies in three independent Japanese and European cohorts, consisting of 1546 CSC samples and 13,029 controls, identified two novel CSC susceptibility loci: TNFRSF10A-LOC389641 and near GATA5 (rs13278062, odds ratio = 1.35, P = 1.26 × 10−13; rs6061548, odds ratio = 1.63, P = 5.36 × 10−15). A T allele at TNFRSF10A-LOC389641 rs13278062, a risk allele for CSC, is known to be a risk allele for AMD. This study not only identified new susceptibility genes for CSC, but also improves the understanding of the pathogenesis of AMD.

Sign in / Sign up

Export Citation Format

Share Document