scholarly journals Gpr124 is essential for blood–brain barrier integrity in central nervous system disease

2017 ◽  
Vol 23 (4) ◽  
pp. 450-460 ◽  
Author(s):  
Junlei Chang ◽  
Michael R Mancuso ◽  
Carolina Maier ◽  
Xibin Liang ◽  
Kanako Yuki ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
Central Nervous System Disease ◽  
Nervous System Disease ◽  
Brain Barrier ◽  
Barrier Integrity ◽  
System Disease ◽  
Blood Brain ◽  
Blood Brain Barrier Integrity

scholarly journals Endothelial β-Catenin Signaling Is Required for Maintaining Adult Blood–Brain Barrier Integrity and Central Nervous System Homeostasis

Circulation ◽  
2016 ◽  
Vol 133 (2) ◽  
pp. 177-186 ◽  
Author(s):  
Khiem A. Tran ◽  
Xianming Zhang ◽  
Dan Predescu ◽  
Xiaojia Huang ◽  
Roberto F. Machado ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Barrier Integrity ◽  
Blood Brain ◽  
Blood Brain Barrier Integrity

scholarly journals Lipoic Acid Affects Cellular Migration into the Central Nervous System and Stabilizes Blood-Brain Barrier Integrity

2006 ◽  
Vol 177 (4) ◽  
pp. 2630-2637 ◽  
Author(s):  
Gerty Schreibelt ◽  
René J. P. Musters ◽  
Arie Reijerkerk ◽  
Lody R. de Groot ◽  
Susanne M. A. van der Pol ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
Lipoic Acid ◽  
Cellular Migration ◽  
Brain Barrier ◽  
Barrier Integrity ◽  
Blood Brain ◽  
The Central Nervous System ◽  
Blood Brain Barrier Integrity

scholarly journals Permeability of the Blood-Brain Barrier and Transport of Nanobodies Across the Blood-Brain Barrier

2018 ◽  
Vol 62 (1) ◽  
pp. 59-66 ◽  
Author(s):  
I. Širochmanová ◽  
Ľ. Čomor ◽  
E. Káňová ◽  
I. Jiménez-Munguía ◽  
Z. Tkáčová ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
Chemical Properties ◽  
Cost Effective ◽  
Central Nervous System Disease ◽  
Brain Barrier ◽  
Promising Alternative ◽  
Blood Brain ◽  
The Central Nervous System

Abstract The presence of a blood-brain barrier (BBB) and a blood-cerebrospinal fluid barrier presents animmense challenge for effective delivery of therapeutics to the central nervous system. Many potential drugs, which are effective at their site of action, have failed due to the lack of distribution in sufficient quantity to the central nervous system (CNS). In consequence, many diseases of the central nervous system remain undertreated. Antibodies, IgG for example, are difficult to deliver to the CNS due to their size (~155 kDa), physico-chemical properties and the presence of Fc receptor on the blood-brain barrier. Smaller antibodies, like the recently developed nanobodies, may overcome the obstacle of the BBB and enter into the CNS. The nanobodies are the smallest available antigen-binding fragments harbouring the full antigenbinding capacity of conventional antibodies. They represent a new generation of therapeutics with exceptional properties, such as: recognition of unique epitopes, target specificity, high affinity, high solubility, high stability and high expression yields in cost-effective recombinant production. Their ability to permeate across the BBBmakes thema promising alternative for central nervous system disease therapeutics. In this review, we have systematically presented different aspects of the BBB, drug delivery mechanisms employed to cross the BBB, and finally nanobodies — a potential therapeutic molecule against neuroinfections.

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