scholarly journals Selective Blockade of Dopamine D3 Receptors Enhances while D2 Receptor Antagonism Impairs Social Novelty Discrimination and Novel Object Recognition in Rats: A Key Role for the Prefrontal Cortex

2011 ◽  
Vol 37 (3) ◽  
pp. 770-786 ◽  
Author(s):  
David JG Watson ◽  
Florence Loiseau ◽  
Manuela Ingallinesi ◽  
Mark J Millan ◽  
Charles A Marsden ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Object Recognition ◽  
D2 Receptor ◽  
Novel Object Recognition ◽  
Dopamine D3 Receptors ◽  
Novel Object ◽  
Selective Blockade ◽  
D3 Receptors ◽  
Dopamine D3 ◽  
Social Novelty Discrimination

scholarly journals Repetitive Mild Traumatic Brain Injury in Rats Impairs Cognition, Enhances Prefrontal Cortex Neuronal Activity, and Reduces Pre-synaptic Mitochondrial Function

2021 ◽  
Vol 15 ◽  
Author(s):  
Yin Feng ◽  
Keguo Li ◽  
Elizabeth Roth ◽  
Dongman Chao ◽  
Christina M. Mecca ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Prefrontal Cortex ◽  
Object Recognition ◽  
Brain Injury ◽  
Neuronal Activity ◽  
Home Cage ◽  
Novel Object Recognition ◽  
Novel Object ◽  
Closed Head

A major hurdle preventing effective interventions for patients with mild traumatic brain injury (mTBI) is the lack of known mechanisms for the long-term cognitive impairment that follows mTBI. The closed head impact model of repeated engineered rotational acceleration (rCHIMERA), a non-surgical animal model of repeated mTBI (rmTBI), mimics key features of rmTBI in humans. Using the rCHIMERA in rats, this study was designed to characterize rmTBI-induced behavioral disruption, underlying electrophysiological changes in the medial prefrontal cortex (mPFC), and associated mitochondrial dysfunction. Rats received 6 closed-head impacts over 2 days at 2 Joules of energy. Behavioral testing included automated analysis of behavior in open field and home-cage environments, rotarod test for motor skills, novel object recognition, and fear conditioning. Following rmTBI, rats spent less time grooming and less time in the center of the open field arena. Rats in their home cage had reduced inactivity time 1 week after mTBI and increased exploration time 1 month after injury. Impaired associative fear learning and memory in fear conditioning test, and reduced short-term memory in novel object recognition test were found 4 weeks after rmTBI. Single-unit in vivo recordings showed increased neuronal activity in the mPFC after rmTBI, partially attributable to neuronal disinhibition from reduced inhibitory synaptic transmission, possibly secondary to impaired mitochondrial function. These findings help validate this rat rmTBI model as replicating clinical features, and point to impaired mitochondrial functions after injury as causing imbalanced synaptic transmission and consequent impaired long-term cognitive dysfunction.

scholarly journals Galanin (1–15)-fluoxetine interaction in the novel object recognition test. Involvement of 5-HT1A receptors in the prefrontal cortex of the rats

2019 ◽  
Vol 155 ◽  
pp. 104-112 ◽  
Author(s):  
Antonio Flores-Burgess ◽  
Carmelo Millón ◽  
Belen Gago ◽  
Laura García-Durán ◽  
Noelia Cantero-García ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Object Recognition ◽  
Recognition Test ◽  
Fluoxetine Interaction ◽  
Novel Object Recognition ◽  
The Novel ◽  
Object Recognition Test ◽  
Novel Object ◽  
Novel Object Recognition Test

scholarly journals Social State Influences Memory in Novel Object Recognition Test Through Oxidative Stress Balance in Male Rats

2018 ◽  
Vol 8 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Hamidreza Famitafreshi ◽  
Morteza Karimian
Keyword(s):  
Oxidative Stress ◽  
Prefrontal Cortex ◽  
Object Recognition ◽  
Recognition Test ◽  
Memory Performance ◽  
Novel Object Recognition ◽  
Object Recognition Test ◽  
Novel Object ◽  
Novel Object Recognition Test ◽  
Nitrite Nitrate

Objective:Social isolation is associated with adverse effects on brain functions. According to previous studies, the reduction of oxidative stress improves cognitive functions. Memory performance is dependent on hippocampus and prefrontal function. The aim of this study is to show that impairment of memory in object recognition test in isolation state is accompanied by deregulation of oxidative stress balance in related areas.Methods and Materials:In this study, 14 male Sprague-Dawley rats were randomly divided into two groups as follows: social and isolation. Socialization and isolation plus one week of acclimatization occurred for fourteen days. At the end of the study, after performing behavioral test, (novel object recognition test) rats were anesthetized and sacrificed. After preparation of tissues in controlled condition, oxidative stress status in hippocampus and prefrontal cortex for Malondialdehyde (MDA), glutathione and nitrite/nitrate was assessed.Results:MDA in the hippocampus and prefrontal cortex was higher in isolated rats compared to social rats. Glutathione and nitrite/nitrate in the hippocampus and prefrontal cortex were lower in isolated rats compared to social rats. Memory performance in novel object recognition test both in short term and long term was better in social rats.Conclusion:Memory performance in novel object recognition test is influenced by social and oxidative stress status. So improving memory is possible through socialization and improvement of antioxidant status.

scholarly journals Impact of early exposure to a cafeteria diet on prefrontal cortex monoamines and novel object recognition in adolescent rats

2019 ◽  
Vol 363 ◽  
pp. 191-198 ◽  
Author(s):  
E. Moreton ◽  
P. Baron ◽  
S. Tiplady ◽  
S. McCall ◽  
B. Clifford ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Object Recognition ◽  
Cafeteria Diet ◽  
Novel Object Recognition ◽  
Early Exposure ◽  
Novel Object ◽  
Adolescent Rats

scholarly journals Mice deficient in the NAAG synthetase II gene Rimkla are impaired in a novel object recognition task

2021 ◽  
Author(s):  
Ivonne Becker ◽  
Lihua Wang‐Eckhardt ◽  
Julia Lodder‐Gadaczek ◽  
Yong Wang ◽  
Agathe Grünewald ◽  
...  
Keyword(s):  
Object Recognition ◽  
Recognition Task ◽  
Novel Object Recognition ◽  
Novel Object ◽  
Object Recognition Task ◽  
Novel Object Recognition Task
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