Background:
Dopamine agonists are useful drugs for the management of patients with Parkinson's disease in the early
stages and in later stages of the disease. Parkinson's disease is a progressive neurodegenerative disease that primarily affects dopamine-producing nerve cells in the brain. They bind to dopamine receptors in nerve cells that regulate body movement and motor function. Electroanalytical methods are used in medicinal, clinical and pharmaceutical research. The voltammetry is one of the most
commonly used electroanalytical methods. The aims of this review are to gather and discuss studies of voltammetric methods used in
determination of dopamine agonists.
Method:
This review includes the use of various voltammetric methods for determination studies of dopamine agonists from pharmaceutical dosage forms and biological samples. These studies were examined in terms of used voltammetric method or methods, working electrode, buffer, pH and validation parameters.
Results:
Cabergoline, pramipexole, ropinirole have more studies, while bromocriptine and apomorphine have fewer studies in the
literature. Differential pulse voltammetry and square wave voltammetry methods were the most applied methods for determination of
dopamine agonist drugs from pharmaceuticals and biological samples. But, stripping, cyclic and lineer sweep voltammetry methods
are less applied methods. In this studies, a lot of modified electrodes were developed and used to analyse of dopamine agonists.
Conclusion:
The voltammetric methods supply determination of therapeutic agents and/or their metabolites in clinical samples at
extremely low concentrations without the necessity for the sample pre-treatment or time consuming extraction steps. Also the modified electrodes and validated voltammetric methods provide good stability, repeatability, reproducibility and high recovery for the
analysis of the analyte.
The Effect of Dopamine Agonists on Adaptive and Aberrant Salience in Parkinson's Disease