scholarly journals Parvalbumin Interneurons of the Mouse Nucleus Accumbens are Required For Amphetamine-Induced Locomotor Sensitization and Conditioned Place Preference

2017 ◽  
Vol 43 (5) ◽  
pp. 953-963 ◽  
Author(s):  
Xiaoting Wang ◽  
David A Gallegos ◽  
Vladimir M Pogorelov ◽  
Justin K O’Hare ◽  
Nicole Calakos ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Conditioned Place Preference ◽  
Place Preference ◽  
Locomotor Sensitization ◽  
Parvalbumin Interneurons

scholarly journals Cocaine-dependent acquisition of locomotor sensitization and conditioned place preference requires D1 dopaminergic signaling through a cyclic AMP, NCS-Rapgef2, ERK and Egr-1/Zif268 pathway

2020 ◽  
Author(s):  
Sunny Zhihong Jiang ◽  
Sean Sweat ◽  
Sam Dahlke ◽  
Kathleen Loane ◽  
Gunner Drossel ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Conditioned Place Preference ◽  
Mouse Brain ◽  
Place Preference ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Locomotor Sensitization ◽  
Erk Activation ◽  
Erk Phosphorylation ◽  
Dopamine Signaling

ABSTRACTElucidation of the underlying mechanism of dopamine signaling to ERK that underlies plasticity in dopamine D1 receptor expressingneurons leadingto acquired cocaine preference is incomplete. NCS-Rapgef2 is a novel cAMP effector, expressed in neuronal and endocrine cells in adult mammals, that is required for D1 dopamine receptor-dependent ERK phosphorylation in mouse brain. In this report, we studied the effects of abrogating NCS-Rapgef2 expression on cAMP-dependent ERK→Egr-1/zif268 signaling in cultured neuroendocrine cells; in D1 medium spiny neurons (MSNs) of nucleus accumbens slices; and in mouse brain in a region-specific manner. NCS-Rapgef2 gene deletion in the nucleus accumbens (NAc) in adult mice, using AAV-mediated expression of cre recombinase, eliminated cocaine-induced ERK phosphorylation and Egr-1/Zif268 upregulation in D1-MSNs and cocaine-induced behaviors including locomotor sensitization and conditioned place preference (CPP). Abrogation of NCS-Rapgef2 gene expression in medium prefrontal cortex and basolateral amygdala, by crossing mice bearing a floxed Rapgef2 allele with a cre mouse line driven by calcium/calmodulin-dependent kinase IIα promoter also eliminated cocaine-induced phospho-ERK activation and Egr-1/Zif268 induction, but without effect on the cocaine-induced behaviors. Our results indicate that NCS-Rapgef2 signaling to ERK in dopamine D1-receptor expressing neurons in the NAc, butnotin corticolimbic areas, contributes to cocaine-induced locomotor sensitization and CPP. Ablation of cocaine-dependent ERK activation by elimination of NCS-Rapgef2 occurred with no effect on phosphorylation of CREB in D1 dopaminoceptive neurons of NAc. This study reveals a new cAMP-dependent signaling pathway for cocaine-induced behavioral adaptations, mediated through NCS-Rapgef2/phospho-ERK activation, independently of PKA/CREB signaling.SIGNIFICANCE STATEMENTERK phosphorylation in dopamine D1 receptor expressing neurons exerts a pivotal role in psychostimulant-induced neuronal gene regulation and behavioraladaptation, including locomotor sensitization and drug preference in rodents. In this study, we examined the role of dopamine signaling through the D1 receptor via a novel pathway initiated through the cAMP-activated guanine nucleotide exchange factor NCS-Rapgef2 in mice. NCS-Rapgef2 in the nucleus accumbens is required for activation of ERK and Egr-1/Zif268 in D1 dopaminoceptive neurons after acute cocaine administration, and subsequentenhanced locomotor response anddrugseeking behavior after repeated cocaine administration. This novel component in dopamine signaling provides a potential new target for intervention in psychostimulant-shaped behaviors, and new understanding of how D1-MSNs encode the experience of psychomotor stimulant exposure.

scholarly journals Loss of β-arrestin2 in D2 cells alters neuronal excitability in the nucleus accumbens and behavioral responses to psychostimulants and opioids

2019 ◽  
Author(s):  
Kirsten A. Porter-Stransky ◽  
Alyssa K. Petko ◽  
Saumya L. Karne ◽  
L. Cameron Liles ◽  
Nikhil M. Urs ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
G Protein ◽  
Conditioned Place Preference ◽  
Neuronal Excitability ◽  
Drugs Of Abuse ◽  
Behavioral Responses ◽  
Place Preference ◽  
Locomotor Sensitization ◽  
Drug Induced ◽  
G Protein Coupled

AbstractPsychostimulants and opioids increase dopamine (DA) neurotransmission, activating D1 and D2 G protein-coupled receptors. β-arrestin2 (βarr2) desensitizes and internalizes these receptors and initiates G protein-independent signaling. Previous work revealed that mice with a global or cell-specific knockout of βarr2 have altered responses to certain drugs; however, the effects of βarr2 on the excitability of medium spiny neurons (MSNs) and its role in mediating the rewarding effects of drugs of abuse are unknown. D1-Cre and D2-Cre transgenic mice were crossed with floxed βarr2 mice to eliminate βarr2 specifically in cells containing either D1 (D1βarr2-KO) or D2 (D2βarr2-KO) receptors. We used slice electrophysiology to characterize the role of βarr2 in modulating D1 and D2 nucleus accumbens MSN intrinsic excitability in response to DA and tested the locomotor-activating and rewarding effects of cocaine and morphine in these mice. We found that eliminating βarr2 attenuated the ability of DA to inhibit D2-MSNs but had little effect on the DA response of D1-MSNs. While D1βarr2-KO mice had mostly normal drug responses, D2βarr2-KO mice showed dose-dependent reductions in acute locomotor responses to cocaine and morphine, attenuated locomotor sensitization to cocaine, and blunted cocaine reward measured with conditioned place preference. Both D2βarr2-KO and D1βarr2-KO mice displayed an enhanced conditioned place preference for the highest dose of morphine. These results indicate that D2-derived βarr2 functionally contributes to the ability of DA to inhibit D2-MSNs and multiple behavioral responses to psychostimulants and opioids, while loss of βarr2 in D1 neurons has little impact on D1-MSN excitability or drug-induced behaviors.

Blockage of acquisition and expression of morphine-induced conditioned place preference in rats due to activation of glutamate receptors type II/III in nucleus accumbens

2015 ◽  
Vol 135 ◽  
pp. 192-198 ◽  
Author(s):  
Negar Baharlouei ◽  
Abdolrahman Sarihi ◽  
Alireza Komaki ◽  
Siamak Shahidi ◽  
Abbas Haghparast
Keyword(s):  
Nucleus Accumbens ◽  
Glutamate Receptors ◽  
Conditioned Place Preference ◽  
Place Preference ◽  
Type Ii

Morphine-induced conditioned place preference in rats is inhibited by electroacupuncture at 2 Hz: Role of enkephalin in the nucleus accumbens

2010 ◽  
Vol 58 (1) ◽  
pp. 233-240 ◽  
Author(s):  
Jing Liang ◽  
Xing-Jie Ping ◽  
Yi-Jing Li ◽  
Yao-Ying Ma ◽  
Liu-Zhen Wu ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Conditioned Place Preference ◽  
Place Preference

Intra-nucleus-accumbens SKF38393 improved the impaired acquisition of morphine-conditioned place preference in depression-like rats

PsyCh Journal ◽  
2012 ◽  
Vol 1 (1) ◽  
pp. 2-14 ◽  
Author(s):  
Jun Gao ◽  
Ning Zhu ◽  
Min Feng ◽  
Xiaolu Meng ◽  
Nan Sui
Keyword(s):  
Nucleus Accumbens ◽  
Conditioned Place Preference ◽  
Place Preference

scholarly journals Nucleus Accumbens CREB Activity is Necessary for Nicotine Conditioned Place Preference

2009 ◽  
Vol 34 (8) ◽  
pp. 1993-2001 ◽  
Author(s):  
Darlene H Brunzell ◽  
Yann S Mineur ◽  
Rachael L Neve ◽  
Marina R Picciotto
Keyword(s):  
Nucleus Accumbens ◽  
Conditioned Place Preference ◽  
Place Preference

Melatonin decreases cocaine-induced locomotor sensitization and cocaine-conditioned place preference in rats

2021 ◽  
Vol 132 ◽  
pp. 97-110
Author(s):  
Susana Barbosa-Méndez ◽  
Gilberto Pérez-Sánchez ◽  
Enrique Becerril-Villanueva ◽  
Alberto Salazar-Juárez
Keyword(s):  
Conditioned Place Preference ◽  
Place Preference ◽  
Locomotor Sensitization

Ghrelin receptor antagonism of fentanyl‐induced conditioned place preference, intravenous self‐administration, and dopamine release in the nucleus accumbens in rats

2019 ◽  
Vol 25 (6) ◽  
Author(s):  
Magdalena Sustkova‐Fiserova ◽  
Nina Puskina ◽  
Tereza Havlickova ◽  
Marek Lapka ◽  
Kamila Syslova ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Conditioned Place Preference ◽  
Dopamine Release ◽  
Place Preference ◽  
Self Administration ◽  
Receptor Antagonism ◽  
Ghrelin Receptor

Functional interaction between the orexin-1 and CB1 receptors within the nucleus accumbens in the conditioned place preference induced by the lateral hypothalamus stimulation

2015 ◽  
Vol 132 ◽  
pp. 42-48 ◽  
Author(s):  
Zahra Fatahi ◽  
Nasim Assar ◽  
Dorna Mahmoudi ◽  
Pouyan Pahlevani ◽  
Marzieh Moradi ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Conditioned Place Preference ◽  
Lateral Hypothalamus ◽  
Place Preference ◽  
Cb1 Receptors ◽  
Functional Interaction
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