scholarly journals Application of the Sensory Contact Model for Pharmacological Studies under Simulated Clinical Conditions

2007 ◽  
Author(s):  
Natalia Kudryavtseva ◽  
Damira Avgustinovich ◽  
Natalia Bondar ◽  
Michael Tenditnik ◽  
Irina Kovalenko
Keyword(s):  
Contact Model ◽  
Sensory Contact ◽  
Sensory Contact Model ◽  
Pharmacological Studies ◽  
Clinical Conditions

Effects of Chronic Caffeine Administration on Behavioral and Molecular Adaptations to Sensory Contact Model Induced Stress in Adolescent Male Mice

2020 ◽  
Vol 50 (5) ◽  
pp. 374-383
Author(s):  
Michael Kamal Ibrahim ◽  
Mohamed Kamal ◽  
Rajiv Tikamdas ◽  
Roua Aref Nouh ◽  
Jiang Tian ◽  
...  
Keyword(s):  
Contact Model ◽  
Adolescent Male ◽  
Male Mice ◽  
Sensory Contact ◽  
Induced Stress ◽  
Sensory Contact Model ◽  
Chronic Caffeine

scholarly journals AGGRESSIVE BEHAVIOR CORRECTION BY THE TRANSPLANTATION OF IN VITRO MODULATED IMMUNE CELLS

2021 ◽  
Vol 23 (4) ◽  
pp. 693-698
Author(s):  
E. V. Markova ◽  
E. V. Serenko ◽  
M. A. Knyazheva
Keyword(s):  
Aggressive Behavior ◽  
Immune Cells ◽  
Depressive Disorders ◽  
Brain Structures ◽  
Psychoactive Substances ◽  
Pathogenetic Mechanisms ◽  
Sensory Contact ◽  
Sensory Contact Model ◽  
Mutual Regulation

Aggression is a serious biomedical problem associated with a high percentage of patients and a lack of selective corrective agents. The most frequent increase in aggressiveness occurs in patients with depressive disorders, schizophrenia, reactive psychoses and adjustment disorders, which are known to be characterized by immunological dysfunction. Antipsychotics are widely used in the correction of psychomotor agitation; the antipsychotic effect of these drugs is manifested in the achievement of a sedative effect. However, like other psychoactive substances, they have a number of side effects that limit their long-term use and determines the need to search for new approaches to the correction of affective disorders. Experimental modeling of aggression is one of the main approaches for studying its pathogenetic mechanisms and searching for new effective therapeutic agents for the treatment. The study of the aggression pathogenetic mechanisms and the search for approaches to therapy within the framework of neuroimmune interaction is currently extremely promising. Currently, there is a large number of clinical and experimental data indicating interrelated changes in the functional activity of the nervous and immune systems during aggression. The leading links in the pathogenetic mechanism of aggression is the violation of the production and mutual regulation of cytokines, neurotransmitters, neuropeptides, growth factors, hormones, the effects of which are mediated by the cellular elements of the immune system. Given the immune cells essential role in the pathogenesis of aggression and the psychoactive substances unidirectional effect on the immune and nervous cells, make it possible to consider immune cells as model objects for influencing the intersystem functional relationship in order to edit the aggressive phenotype. The aim of the study was to investigate the effect of in vitro neuroleptic-modulated immune cells transplantation on behavioral phenotype and brain cytokines in aggressive syngeneic recipients. Aggressive behavior was formed in active male mice (CBA × C57Bl/6) F1 as a result of the experience of 20- fold victories in inter-male confrontations (distant sensory contact model). Aggressive mice splenocytes were treated in vitro with chlorpromazine and intravenously injected to syngeneic aggressive recipients. It has been demonstrated that modulated in vitro by chlorpromazine splenocytes of aggressive mice after transplantation edit the syngeneic aggressive recipient’s behavior against the background of a decrease in cytokines IL-1β, IL-2, IL-6, IFNγ and an increase in IL-4 in pathogenetically significant for aggression brain structures. The mechanisms of the aggressive behavior correcting effect of modulated immune cells are discussed. 

Conspectus of Phytoconstituents and Pharmacological activities of Barleria lupulina Lindl.: A Review

2020 ◽  
Vol 06 ◽  
Author(s):  
Sabyasachi Banerjee ◽  
Subhasis Banerjee ◽  
Gaurab Kumar Jha ◽  
Sankhadip Bose
Keyword(s):  
Traditional Medicine ◽  
Folk Medicine ◽  
Immunomodulatory Activity ◽  
Traditional Medicines ◽  
Novel Drugs ◽  
The Family ◽  
Pharmacological Studies ◽  
Abundance And Diversity ◽  
Clinical Conditions ◽  
Body Ache

Folk medicine system served the mankind as remedy of several clinical conditions since antiquity. Abundance and diversity of synthetic medicaments eclipse the implementation of traditional medicines for some times but the adverse reactions of synthetic medicaments have shifted people to traditional medicine system again to retrieve its position. Over a duration of time advancement in research and technology on traditional medicine systems attracted people to start believing in the safety aspects of natural products. This review illustrates the diverse pharmacological benefits of numerous phytoconstituents of a magical plant, Barleria lupulina Lindl., belonging to the family Acanthaceaec, native to East Africa (Mauritius), Eastern India, Bangladesh; apart from that it is also cultured in some places like Sri Lanka. It is commonly known as hophead Philippine violet, Lal-tarokh, etc. Traditionally the plant leaves are utilized to medicate in snakebites, dog bites, swelling, boils, sexual disorder, cough, fever, body ache, eczema, itches, bleeding wounds and rheumatism. The other pharmacological properties include antibacterial, anti-inflammatory, antidiabetic, antiulcer, antimitotic, diuretic, saluretic, kaliuretic, antiarthritic, antiviral, psychopharmacological, anticancer, analgesic, antioxidant and immunomodulatory activity. Till date, diversified phytoconstituents were isolated and structurally elucidated, in which saponins, glycosides, resins, steroids, phenolic compounds, alkaloids, tannins and flavonoids are the predominant one. With this ample information, the herb can be considered for isolating biomarkers to develop new lead which eventually leads to the making of novel drugs. In an attempt to illuminate the importance of B. lupulina, this review has been developed upon contemplating its traditional, morphological, ecological, phytochemical, and pharmacological studies though few information is available in the web.

Sign in / Sign up

Export Citation Format

Share Document