Rapid preparation of the mitotic kinesin Eg5 inhibitor monastrol using controlled microwave-assisted synthesis

Nature Protocols ◽

10.1038/nprot.2006.436 ◽

2007 ◽

Vol 2 (2) ◽

pp. 317-321 ◽

Author(s):

Doris Dallinger ◽

C Oliver Kappe

Keyword(s):

Microwave Assisted Synthesis ◽

Rapid Preparation ◽

Microwave Assisted ◽

Kinesin Eg5 ◽

Mitotic Kinesin Eg5 ◽

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New environmentally benign protocol for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones: Practical access to mitotic kinesin EG5 inhibitor Monastrol

ARKIVOC ◽

10.3998/ark.5550190.0006.325 ◽

2005 ◽

Vol 2005 (3) ◽

pp. 228-236 ◽

Author(s):

D. Subhas Bose ◽

Madapa Sudharshan ◽

Sanjay W Chavhan

Keyword(s):

Environmentally Benign ◽

Kinesin Eg5 ◽

Mitotic Kinesin Eg5 ◽

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Abstract 4430: A novel mitotic kinesin Eg5 inhibitor exerts the growth-inhibitory effect in cancer cells in a manner independent of induction of monoastral formation but dependent onKRASmutation status

10.1158/1538-7445.am10-4430 ◽

2010 ◽

Author(s):

Takehito Shukuya ◽

Hye-Ran Lee ◽

Masakuni Serizawa ◽

Naohisa Ogo ◽

Akira Asai ◽

...

Keyword(s):

Cancer Cells ◽

Inhibitory Effect ◽

Growth Inhibitory Effect ◽

Growth Inhibitory ◽

Kinesin Eg5 ◽

Mitotic Kinesin Eg5 ◽

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Abstract 4427: Efficacy of a novel mitotic kinesin Eg5 inhibitor in docetaxel-resistant non-small cell lung cancer cells

10.1158/1538-7445.am10-4427 ◽

2010 ◽

Author(s):

Masakuni Serizawa ◽

Naohisa Ogo ◽

Akira Asai ◽

Nobuyuki Yamamoto ◽

Yasuhiro Koh

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cancer Cells ◽

Cell Lung Cancer ◽

Lung Cancer Cells ◽

Small Cell Lung ◽

Kinesin Eg5 ◽

Mitotic Kinesin Eg5 ◽

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A Remarkable Rate Acceleration of the One-Pot Three-Component Cyclocondensation Reaction at Room Temperature: An Expedient Synthesis of Mitotic Kinesin Eg5 Inhibitor Monastrol

Synlett ◽

10.1055/s-2004-815416 ◽

2004 ◽

pp. 0279-0282 ◽

Author(s):

D. Subhas Bose ◽

Racherla Kishore Kumar ◽

Liyakat Fatima

Keyword(s):

Room Temperature ◽

One Pot ◽

Rate Acceleration ◽

Kinesin Eg5 ◽

The One ◽

Mitotic Kinesin Eg5 ◽

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ChemInform Abstract: Synthesis and Reactions of Biginelli Compounds. Part 19. X-Ray Structure, Conformational Analysis, Enantioseparation, and Determination of Absolute Configuration of the Mitotic Kinesin Eg5 Inhibitor Monastrol.

10.1002/chin.200025031 ◽

2010 ◽

Vol 31 (25) ◽

pp. no-no

Author(s):

C. Oliver Kappe ◽

Oleg V. Shishkin ◽

Georg Uray ◽

Petra Verdino

Keyword(s):

Conformational Analysis ◽

Absolute Configuration ◽

X Ray ◽

Biginelli Compounds ◽

Determination Of Absolute Configuration ◽

Kinesin Eg5 ◽

Mitotic Kinesin Eg5 ◽

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Integration of high speed microwave chemistry and a statistical ‘design of experiment’ approach for the synthesis of the mitotic kinesin Eg5 inhibitor monastrol

Tetrahedron ◽

10.1016/j.tet.2007.12.056 ◽

2008 ◽

Vol 64 (9) ◽

pp. 2035-2041 ◽

Author(s):

Toma N. Glasnov ◽

Heather Tye ◽

C. Oliver Kappe

Keyword(s):

Design Of Experiment ◽

Statistical Design ◽

Microwave Chemistry ◽

Kinesin Eg5 ◽

Mitotic Kinesin Eg5 ◽

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The first highly stereoselective approach to the mitotic kinesin Eg5 inhibitor HR22C16 and its analogues

Tetrahedron Asymmetry ◽

10.1016/j.tetasy.2009.12.029 ◽

2010 ◽

Vol 21 (2) ◽

pp. 226-231 ◽

Author(s):

Sen Xiao ◽

Xiao-Xin Shi

Keyword(s):

Kinesin Eg5 ◽

Mitotic Kinesin Eg5 ◽

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A Remarkable Rate Acceleration of the One-Pot Three-Component Cyclocondensation Reaction at Room Temperature: An Expedient Synthesis of Mitotic Kinesin Eg5 Inhibitor Monastrol.

10.1002/chin.200424140 ◽

2004 ◽

Vol 35 (24) ◽

Author(s):

D. Subhas Bose ◽

Racherla Kishore Kumar ◽

Liyakat Fatima

Keyword(s):

Room Temperature ◽

One Pot ◽

Rate Acceleration ◽

Cyclocondensation Reaction ◽

Kinesin Eg5 ◽

The One ◽

Mitotic Kinesin Eg5 ◽

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X-Ray Structure, Conformational Analysis, Enantioseparation, and Determination of Absolute Configuration of the Mitotic Kinesin Eg5 Inhibitor Monastrol

Tetrahedron ◽

10.1016/s0040-4020(00)00116-2 ◽

2000 ◽

Vol 56 (13) ◽

pp. 1859-1862 ◽

Author(s):

C.Oliver Kappe ◽

Oleg V Shishkin ◽

Georg Uray ◽

Petra Verdino

Keyword(s):

Conformational Analysis ◽

Absolute Configuration ◽

X Ray ◽

Determination Of Absolute Configuration ◽

Kinesin Eg5 ◽

Mitotic Kinesin Eg5 ◽

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Interaction of the mitotic kinesin Eg5 inhibitor monastrol with P-glycoprotein

Naunyn-Schmiedeberg s Archives of Pharmacology ◽

10.1007/s00210-005-0022-5 ◽

2005 ◽

Vol 372 (4) ◽

pp. 291-299 ◽

Author(s):

Tanja Peters ◽

Heike Lindenmaier ◽

Walter E. Haefeli ◽

Johanna Weiss

Keyword(s):

P Glycoprotein ◽

Kinesin Eg5 ◽

Mitotic Kinesin Eg5 ◽

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