scholarly journals Diaphragm pacing is associated with reduced survival in ALS patients with respiratory insufficiency

2015 ◽  
Vol 11 (9) ◽  
pp. 484-484 ◽  
Author(s):  
Heather Wood
Keyword(s):  
Respiratory Insufficiency ◽  
Diaphragm Pacing ◽  
Als Patients

Diaphragm Pacing as an Adjunct in Respiratory Insufficiency

Neurosurgery ◽  
1978 ◽  
Vol 2 (1) ◽  
pp. 43-46 ◽  
Author(s):  
Ronald F. Young
Keyword(s):  
Electrical Stimulation ◽  
Case Report ◽  
Respiratory Insufficiency ◽  
Phrenic Nerve ◽  
Social Problems ◽  
Potential Usefulness ◽  
Mechanical Ventilator ◽  
Diaphragm Pacing ◽  
Neurosurgical Patients ◽  
Stimulation Of

Abstract Most neurosurgical patients with permanent partial or complete respiratory insufficiency are managed with a mechanical ventilator and tracheostomy. This method presents many medical, technical, emotional, and social problems. A case report is presented that illustrates the potential usefulness of electrical stimulation of the phrenic nerve (“diaphragm pacing”) as an alternate method of therapy for respiratory insufficiency. This paper outlines the indications for, methods of, and problems with such a system and is intended to make its availability more widely appreciated among neurosurgeons.

scholarly journals Development of a prognostic model of respiratory insufficiency or death in amyotrophic lateral sclerosis

2019 ◽  
Vol 53 (4) ◽  
pp. 1802237 ◽  
Author(s):  
Jason Ackrivo ◽  
John Hansen-Flaschen ◽  
E. Paul Wileyto ◽  
Richard J. Schwab ◽  
Lauren Elman ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Respiratory Insufficiency ◽  
Prognostic Model ◽  
Primary Outcome ◽  
Cross Validation ◽  
External Validation ◽  
C Statistic ◽  
Baseline Characteristics ◽  
Als Patients ◽  
Lateral Sclerosis

A clinically useful model to prognose onset of respiratory insufficiency in amyotrophic lateral sclerosis (ALS) would inform disease interventions, communication and clinical trial design. We aimed to derive and validate a clinical prognostic model for respiratory insufficiency within 6 months of presentation to an outpatient ALS clinic.We used multivariable logistic regression and internal cross-validation to derive a clinical prognostic model using a single-centre cohort of 765 ALS patients who presented between 2006 and 2015. External validation was performed using the multicentre Pooled Resource Open-Access ALS Clinical Trials (PRO-ACT) database with 7083 ALS patients. Predictors included baseline characteristics at first outpatient visit. The primary outcome was respiratory insufficiency within 6 months, defined by initiation of noninvasive ventilation, forced vital capacity (FVC) <50% predicted, tracheostomy, or death.Of 765 patients in our centre, 300 (39%) had respiratory insufficiency or death within 6 months. Six baseline characteristics (diagnosis age, delay between symptom onset and diagnosis, FVC, symptom onset site, amyotrophic lateral sclerosis functional rating scale-revised (ALSFRS-R) total score and ALSFRS-R dyspnoea score) were used to prognose the risk of the primary outcome. The derivation cohort c-statistic was 0.86 (95% CI 0.84–0.89) and internal cross-validation produced a c-statistic of 0.86 (95% CI 0.85–0.87). External validation of the model using the PRO-ACT cohort produced a c-statistic of 0.74 (95% CI 0.72–0.75).We derived and externally validated a clinical prognostic rule for respiratory insufficiency in ALS. Future studies should investigate interventions on equivalent high-risk patients.

Diaphragm Pacing for Respiratory Insufficiency

1997 ◽  
Vol 14 (5) ◽  
pp. 369-377 ◽  
Author(s):  
Ronald D. Chervin ◽  
Christian Guilleminault
Keyword(s):  
Respiratory Insufficiency ◽  
Diaphragm Pacing

Diaphragm pacing as an adjunct in respiratory insufficiency

Neurosurgery ◽  
1978 ◽  
Vol 2 (1) ◽  
pp. 43???6 ◽  
Author(s):  
R F Young
Keyword(s):  
Respiratory Insufficiency ◽  
Diaphragm Pacing

Denial and depression in ALS patients and their caregivers: A social-interactive perspective on illness coping

2004 ◽  
Author(s):  
Steven E. Mock ◽  
Elaine Wethington ◽  
Ishtar Gabriel ◽  
John Turnbull
Keyword(s):  
Als Patients

The wish to hasten death among ALS patients in a palliative care program

2007 ◽  
Vol 34 (S 2) ◽  
Author(s):  
R Jox ◽  
S Haarmann-Doetkotte ◽  
M Wasner ◽  
GD Borasio
Keyword(s):  
Palliative Care ◽  
Care Program ◽  
Palliative Care Program ◽  
Wish To Hasten Death ◽  
Als Patients
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