scholarly journals Akt regulates progesterone receptor B-dependent transcription and angiogenesis in endometrial cancer cells

Oncogene ◽  
2016 ◽  
Vol 35 (39) ◽  
pp. 5191-5201 ◽  
Author(s):  
I I Lee ◽  
K Maniar ◽  
J P Lydon ◽  
J J Kim
Keyword(s):  
Endometrial Cancer ◽  
Progesterone Receptor ◽  
Cancer Cells ◽  
Progesterone Receptor B

scholarly journals Progesterone Receptor-B Induction of BIRC3 Protects Endometrial Cancer Cells from AP1-59-Mediated Apoptosis

2011 ◽  
Vol 2 (3) ◽  
pp. 170-181 ◽  
Author(s):  
Nikki L. Neubauer ◽  
Erin C. Ward ◽  
Parin Patel ◽  
Zhenxiao Lu ◽  
Irene Lee ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Progesterone Receptor ◽  
Cancer Cells ◽  
Progesterone Receptor B

scholarly journals Progesterone receptor inhibits the proliferation and invasion of endometrial cancer cells by up regulating Krüppel-like factor 9

2020 ◽  
Vol 9 (4) ◽  
pp. 2220-2230
Author(s):  
Xiaofang Yan ◽  
Huilin Zhang ◽  
Jieqi Ke ◽  
Yongli Zhang ◽  
Chenyun Dai ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Progesterone Receptor ◽  
Cancer Cells ◽  
Proliferation And Invasion

Differential Expression of the A and B Isoforms of Progesterone Receptor in Human Endometrial Cancer Cells.

1997 ◽  
Vol 828 (1 Uterus, The) ◽  
pp. 17-26 ◽  
Author(s):  
KIMBERLY K. LESLIE ◽  
NIRMALA S. KUMAR ◽  
JENNIFER RICHER ◽  
GARETH OWEN ◽  
GLENN TAKIMOTO ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Progesterone Receptor ◽  
Cancer Cells ◽  
Differential Expression

scholarly journals Ligand activated progesterone receptor B drives autophagy-senescence transition through a Beclin-1/Bcl-2 dependent mechanism in human breast cancer cells

Oncotarget ◽  
2016 ◽  
Vol 7 (36) ◽  
pp. 57955-57969 ◽  
Author(s):  
Francesca De Amicis ◽  
Carmela Guido ◽  
Marta Santoro ◽  
Francesca Giordano ◽  
Ada Donà ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Progesterone Receptor ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Beclin 1 ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Progesterone Receptor B ◽  
Dependent Mechanism

scholarly journals Preferential Stimulation of Human Progesterone Receptor B Expression by Estrogen in T-47D Human Breast Cancer Cells

1995 ◽  
Vol 270 (51) ◽  
pp. 30693-30700 ◽  
Author(s):  
J. Dinny Graham ◽  
Shaun D. Roman ◽  
Eileen McGowan ◽  
Robert L. Sutherland ◽  
Christine L. Clarke
Keyword(s):  
Breast Cancer ◽  
Progesterone Receptor ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Human Progesterone Receptor ◽  
Progesterone Receptor B ◽  
Stimulation Of

Megestrol acetate drives endometrial carcinoma cell senescence via interacting with progesterone receptor B/FOXO1 axis

2021 ◽  
pp. 153537022110265
Author(s):  
Hong Wang ◽  
Huirong Shi
Keyword(s):  
Endometrial Cancer ◽  
Progesterone Receptor ◽  
Cancer Cell ◽  
Cell Senescence ◽  
Megestrol Acetate ◽  
G1 Arrest ◽  
Cancer Cell Growth ◽  
Endometrial Cancer Cell ◽  
Cycle Arrest ◽  
Progesterone Receptor B

Megestrol acetate is a common and efficient anticancer progesterone. To explore the activity and the therapeutic mechanisms of megestrol acetate in endometrial cancer, human endometrial cancer cell lines Ishikawa and HHUA overexpressing progesterone receptor A (PR-A) and progesterone receptor B (PR-B) were treated with megestrol acetate. Cell viability, apoptosis, cycle arrest, and senescence, as well as the expressions of p21 and p16, two hallmarks of cellular senescence, were evaluated. Compared with the control, >10 nmol/L megestrol acetate treatment could significantly reduce endometrial cancer cell growth, and induce the irreversible G1 arrest and cell senescence. The expression of cyclin D1 in megestrol acetate treated cells was downregulated, while the expressions of p21 and p16 were upregulated via PR-B isoform. FOXO1 inhibitor AS1842856 could significantly abrogate megestrol acetate-induced cell senescence, suggesting that FOXO1 was involved in megestrol acetate/PR-B axis. These findings may provide a new understanding for the treatment of human endometrial cancer.

Abstract 4711: Epigenetic modulation restores expression of functional progesterone receptor in endometrial cancer cells

2012 ◽  
Author(s):  
Shujie Yang ◽  
Xue Xiao ◽  
Yuping Zhang ◽  
Xiangbing Meng ◽  
Kimberly K. Leslie
Keyword(s):  
Endometrial Cancer ◽  
Progesterone Receptor ◽  
Cancer Cells ◽  
Epigenetic Modulation

scholarly journals Enhancement of progesterone receptor levels by interferons in AE-7 endometrial cancer cells

Cancer ◽  
1993 ◽  
Vol 71 (9) ◽  
pp. 2776-2781 ◽  
Author(s):  
Roberto Angioli ◽  
Michael Untch ◽  
Bernd-Uwe Sevin ◽  
Albert Steren ◽  
Randall D. Hightower ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Progesterone Receptor ◽  
Cancer Cells
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