scholarly journals Hypoxic Respiratory Failure in Term and Near Term Newborns: Perspective from the Neonatal Transfer Service

2011 ◽  
Vol 70 ◽  
pp. 505-505
Author(s):  
S Davidson ◽  
N Ratnavel ◽  
S Mohinuddin ◽  
M F Hird ◽  
A Sinha
Keyword(s):  
Respiratory Failure ◽  
Hypoxic Respiratory Failure ◽  
Term Newborns ◽  
Near Term

A cost-effectiveness analysis of the application of nitric oxide versus oxygen gas for near-term newborns with respiratory failure: Results from a Canadian randomized clinical trial

2000 ◽  
Vol 28 (3) ◽  
pp. 872-878 ◽  
Author(s):  
Philip Jacobs ◽  
Neil N. Finer ◽  
Charlene M.T. Robertson ◽  
Philip Etches ◽  
Edward M. Hall ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Clinical Trial ◽  
Cost Effectiveness ◽  
Respiratory Failure ◽  
Randomized Clinical Trial ◽  
Cost Effectiveness Analysis ◽  
Effectiveness Analysis ◽  
Term Newborns ◽  
Oxygen Gas ◽  
Near Term

Hypoxic respiratory failure in term newborns: clinical indicators for inhaled nitric oxide and extracorporeal membrane oxygenation therapy

2005 ◽  
Vol 20 (3) ◽  
pp. 288-293 ◽  
Author(s):  
Harun Fakioglu ◽  
Balagangadhar R. Totapally ◽  
Dan Torbati ◽  
Andre Raszynski ◽  
Jeffrey B. Sussmane ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Respiratory Failure ◽  
Extracorporeal Membrane Oxygenation ◽  
Inhaled Nitric Oxide ◽  
Clinical Indicators ◽  
Membrane Oxygenation ◽  
Hypoxic Respiratory Failure ◽  
Term Newborns

A Randomized Trial of Early Versus Standard Inhaled Nitric Oxide Therapy in Term and Near-Term Newborn Infants With Hypoxic Respiratory Failure

PEDIATRICS ◽  
2004 ◽  
Vol 113 (3) ◽  
pp. 559-564 ◽  
Author(s):  
G. G. Konduri ◽  
A. Solimano ◽  
G. M. Sokol ◽  
J. Singer ◽  
R. A. Ehrenkranz ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Respiratory Failure ◽  
Randomized Trial ◽  
Newborn Infants ◽  
Inhaled Nitric Oxide ◽  
Term Newborn ◽  
Hypoxic Respiratory Failure ◽  
Near Term ◽  
Nitric Oxide Therapy

scholarly journals Early Inhaled Nitric Oxide Therapy for Term and Near-Term Newborn Infants with Hypoxic Respiratory Failure: Neurodevelopmental Follow-Up

2007 ◽  
Vol 150 (3) ◽  
pp. 235-240.e1 ◽  
Author(s):  
G. Ganesh Konduri ◽  
Betty Vohr ◽  
Charlene Robertson ◽  
Gregory M. Sokol ◽  
Alfonso Solimano ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Respiratory Failure ◽  
Newborn Infants ◽  
Inhaled Nitric Oxide ◽  
Term Newborn ◽  
Hypoxic Respiratory Failure ◽  
Near Term ◽  
Nitric Oxide Therapy

Inhaled Nitric Oxide Therapy in the Near-Term or Term Neonate with Hypoxic Respiratory Failure

2004 ◽  
Vol 23 (1) ◽  
pp. 5-13 ◽  
Author(s):  
Leslie Williams ◽  
Thomas Shaffer ◽  
Jay Greenspan
Keyword(s):  
Nitric Oxide ◽  
Respiratory Failure ◽  
Vascular Reactivity ◽  
Minute Ventilation ◽  
Strong Relationship ◽  
Inhaled Nitric Oxide ◽  
Term Infants ◽  
Arterial Blood ◽  
Hypoxic Respiratory Failure ◽  
Near Term

Inhaled nitric oxide (iNO) has altered the management strategy for treating near-term and term infants with hypoxic respiratory failure (HRF) There is a strong relationship between HRF and persistent pulmonary hypertension of the newborn (PPHN). PPHN is characterized by elevated pulmonary resistance, pulmonary vasoconstriction, and altered vascular reactivity. The resulting high pulmonary pressure may lead to HRF, which is defined as a relative deficiency of oxygen in arterial blood and insufficient minute ventilation. iNO improves oxygenation and decreases the need for extracorporeal membrane oxygenation. Although iNO therapy is effective, its efficacy can depend on the fine points of its use and on other care the infant is receiving. Even in NICUs that do not have iNO available, those who care for term infants with HRF must be familiar with its use and know when and how to transfer these infants and how to help families through this difficult period. Because iNO therapy will probably be used more frequently in nurseries over the next few years, more information on the safety and efficacy of its use in the broader neonatal population needs to be available.

scholarly journals The Burden of Hypoxic Respiratory Failure in Preterm and Term/Near-term Infants in the United States 2011-2015

10.36469/9682 ◽  
2019 ◽  
Vol 6 (3) ◽  
pp. 130-141
Author(s):  
Shivani Pandya ◽  
Onur Baser ◽  
George J. Wan ◽  
Belinda Lovelace ◽  
Jim Potenziano ◽  
...  
Keyword(s):  
United States ◽  
Respiratory Failure ◽  
Neonatal Intensive Care ◽  
The United States ◽  
Inpatient Setting ◽  
Index Hospitalization ◽  
Related Factors ◽  
Term Infants ◽  
Hypoxic Respiratory Failure ◽  
Near Term

Objectives: This study quantified the burden of hypoxic respiratory failure (HRF)/persistent pulmonary hypertension of newborn (PPHN) in preterm and term/near-term infants (T/NTs) by examining health care resource utilization (HRU) and charges in the United States. Methods: Preterms and T/NTs (≤34 and >34 weeks of gestation, respectively) having HRF/PPHN, with/without meconium aspiration in inpatient setting from January 1, 2011-October 31, 2015 were identified from the Vizient database (first hospitalization=index hospitalization). Comorbidities, treatments, HRU, and charges during index hospitalization were evaluated among preterms and T/NTs with HRF/PPHN. Logistic regression was performed to evaluate mortality-related factors. Results: This retrospective study included 504 preterms and 414 T/NTs with HRF/PPHN. Preterms were more likely to have respiratory distress syndrome, neonatal jaundice, and anemia of prematurity than T/NTs. Preterms had significantly longer inpatient stays (54.1 vs 29.0 days), time in a neonatal intensive care unit (34.1 vs 17.5 days), time on ventilation (4.7 vs 2.2 days), and higher total hospitalization charges ($613,350 vs $422,558) (all P<0.001). Similar rates were observed for use of antibiotics (96.2% vs 95.4%), sildenafil (9.5% vs 8.2%), or inhaled nitric oxide (93.8% vs 94.2%). Preterms had a significantly higher likelihood of mortality than T/NTs (odds ratio: 3.6, 95% confidence interval: 2.3-5.0). Conclusions: The findings of more severe comorbidities, higher HRU, hospitalization charges, and mortality in preterms than in T/NTs underscore the significant clinical and economic burden of HRF/PPHN among infants. The results show significant unmet medical need; further research is warranted to determine new treatments and real-world evidence for improved patient outcomes.

scholarly journals Outcome Predictors in Near Term Infants with Hypoxic Respiratory Failure: Evaluation of NINOS Control Infants † 1248

1998 ◽  
Vol 43 ◽  
pp. 214-214 ◽  
Author(s):  
Neil N Finer ◽  
William D Rhine ◽  
Joel Verter
Keyword(s):  
Respiratory Failure ◽  
Outcome Predictors ◽  
Term Infants ◽  
Hypoxic Respiratory Failure ◽  
Near Term ◽  
Failure Evaluation

scholarly journals Focal ST-segment elevation without coronary occlusion: myocardial infarction with no obstructive coronary atherosclerosis associated with COVID-19—a case report

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Casey Meizinger ◽  
Bruce Klugherz
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Respiratory Failure ◽  
Coronary Atherosclerosis ◽  
Myocardial Injury ◽  
Cardiovascular Complications ◽  
St Segment Elevation ◽  
St Segment ◽  
Hypoxic Respiratory Failure ◽  
Artery Disease

Abstract Background While it is understood that coronavirus disease 2019 (COVID-19) is primarily complicated by respiratory failure, more data are emerging on the cardiovascular complications of this disease. A subset of COVID-19 patients present with ST-elevations on electrocardiogram (ECG) yet normal coronary angiography, a presentation that can fit criteria for myocardial infarction with no obstructive coronary atherosclerosis (MINOCA). There is little known about non-coronary myocardial injury observed in patients with COVID-19, and we present a case that should encourage further conversation and study of this clinical challenge. Case summary An 86-year-old man presented to our institution with acute hypoxic respiratory failure and an ECG showing anteroseptal ST-segment elevation concerning for myocardial infarction. Mechanic ventilation was initiated prior to presentation, and emergent transthoracic echocardiography reported an ejection fraction of 50–55%, with no significant regional wall motion abnormalities. Next, emergent coronary angiography was performed, and no significant coronary artery disease was detected. The patient tested positive for COVID-19. Despite supportive management in the intensive care unit, the patient passed away. Discussion We present a case of COVID-19 that is likely associated with MINOCA. It is crucial to understand that in COVID-19 patients with signs of myocardial infarction, not all myocardial injury is due to obstructive coronary artery disease. In the case of COVID-19 pathophysiology, it is important to consider the cardiovascular effects of hypoxic respiratory failure, potential myocarditis, and significant systemic inflammation. Continued surveillance and research on the cardiovascular complications of COVID-19 is essential to further elucidate management and prognosis.

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