Vitamin D status in pediatric patients with a history of malignancy

Viral croup is one of the most common causes of upper respiratory tract obstruction in children under 6 years of age. Frequent acute respiratory infections (ARIs) and a burdened history of allergies might be triggers for recurrent episodes of viral croup. Purpose — to study vitamin D status in infants with viral croup and the efficacy of cholecalciferol supplements for recurrent episodes prevention. Materials and methods. Hospital(based survey included 128 children aged 4–36 months with viral croup. Vitamin D status was evaluated by measuring serum 25 (OH) D levels. Control studies were performed after 12 weeks. A prospective follow(up study lasted for three years. Results. 32.8±4.1% (42/128) of hospitalized children with viral croup had a history of frequent episodes of ARIs (>6 episodes per year). Recurrent episodes of viral croup were more frequent in children with a burdened history of allergies compared to those who did not have allergies — 46.4±9.4% (13/28) vs. 23.0±4.2% (23/100) (р=0.028). At the time of enrollment, 47.6±4.4% (61/128) of children had optimal concentration of 25 (ОН) D (30–100 ng/ml). Serum 25 (OH) D levels in children who regularly received supplements were 33.5 ng/ml (27.2–44.5) at the time of control. Patients with a level of 25 (OH) D>30 ng/ml were less likely to have recurrent ARIs (0/29) during the observation period compared to those with a level of 25 (OH) D 20–30 ng/ml (25.0±10.8%, 4/16) (p=0.023). In children with a concentration of 25 (OH) D>30 ng/ml, the risks for recurrent episodes of viral croup in the future were 9 times lower (OR=9.00; 95% CI: 1.55–52.27), and the risks of more mild viral croup course were 11.4 times lower (OR=11.40; 95% CI: 1.20–108.29). Conclusions. Insufficient levels of vitamin D were recorded in 46.1±4.4% of children with viral croup. When the concentration of 25 (OH) D in serum increased to >30 ng/ml, the frequency of recurrent ARIs decreased (p=0.023); the risks for recurrent episodes of viral croup decreased, as well as the risks of more severe viral croup course. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of all participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the author. Key words: recurrent episodes, viral croup, children, causes, prevention.

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Assesment of Vitamin D Status in Critically Ill Pediatric Patients

Egyptian Journal of Pediatrics ◽

10.12816/0052969 ◽

2019 ◽

Vol 36 (1-2) ◽

pp. 13-20

Author(s):

Nadin N. Toaima ◽

Farida El Baz ◽

Nesma Safwat ◽

Passant El-Hefnawy

Keyword(s):

Vitamin D ◽

Critically Ill ◽

Pediatric Patients ◽

Vitamin D Status

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The Association Between Vitamin D Status and Pulmonary Function in Pediatric Patients With Cystic Fibrosis

Topics in Clinical Nutrition ◽

10.1097/tin.0000000000000192 ◽

2019 ◽

Vol 35 (3) ◽

pp. 210-221

Author(s):

Allison Gomes ◽

Anna Parker ◽

Rena Zelig

Keyword(s):

Cystic Fibrosis ◽

Vitamin D ◽

Pulmonary Function ◽

Pediatric Patients ◽

Vitamin D Status

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Vitamin D and family history of hypertension in relation to hypertension status among college students

Journal of Human Hypertension ◽

10.1038/s41371-021-00577-6 ◽

2021 ◽

Author(s):

Yendelela L. Cuffee ◽

Ming Wang ◽

Nathaniel R. Geyer ◽

Sangeeta Saxena ◽

Suzanne Akuley ◽

...

Keyword(s):

Vitamin D ◽

Young Adults ◽

Family History ◽

Stepwise Logistic Regression ◽

Targeted Prevention ◽

Vitamin D Status ◽

Hypertension Status ◽

Parental History ◽

History Of ◽

Family History Of Hypertension

AbstractHypertension and vitamin D concentrations have heritable components, although these factors remain uninvestigated in young adults. The objective of this study was to investigate hypertension risk among young adults with respect to family history of hypertension, adjusting for vitamin D status. Resting blood pressure (BP) was measured in 398 individuals aged 18–35 and classified according to the 2017 American Heart Association criteria. Plasma vitamin D metabolite (25(OH)D3; 24,25(OH)2D3; 1,25(OH)2D3) concentrations were determined using liquid chromatography tandem mass spectrometry (LC-MS/MS). Stepwise logistic regression was used to select covariates. Participants' mean age was 21, 30.3% had hypertension, and nearly all unaware of their hypertensive status (90.7%). Compared with no parental history, the adjusted odds ratio (AOR) for hypertension was elevated among participants with two parents having hypertension (AOR = 4.5, 95% CI: 1.70–11.76), adjusting for sex, body mass index, physical activity, and plasma 25(OH)D3. Results for systolic hypertension (SH) were similar but more extreme (two parents AOR = 7.1, 95% CI: 2.82, 17.66), although dihydroxy metabolites (1,25(OH)2D3 and 24,25(OH)2D3) were significant. There was a strong, independent association with dual parental history and hypertension status, regardless of vitamin D status. Hypertension was prevalent in nearly one-third of the sample and underscores the need for targeted prevention for young adults.

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Vitamin D Status in Pediatric Patients with Osteogenesis Imperfecta

Pediatrics & Therapeutics ◽

10.4172/2161-0665.1000103 ◽

2011 ◽

Vol 01 (02) ◽

Author(s):

Muayad Kadhim ◽

Michael B. Bober

Keyword(s):

Vitamin D ◽

Osteogenesis Imperfecta ◽

Pediatric Patients ◽

Vitamin D Status

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A History of Cow’s Milk Allergy Is Associated with Lower Vitamin D Status in Schoolchildren

Hormone Research in Paediatrics ◽

10.1159/000478779 ◽

2017 ◽

Vol 88 (3-4) ◽

pp. 244-250 ◽

Cited By ~ 5

Author(s):

Jenni Rosendahl ◽

Mikael Fogelholm ◽

Anna Pelkonen ◽

Mika J. Mäkelä ◽

Outi Mäkitie ◽

...

Keyword(s):

Vitamin D ◽

Allergic Diseases ◽

Vitamin D Insufficiency ◽

Vitamin D Supplementation ◽

Cow’S Milk ◽

Milk Allergy ◽

Vitamin D Status ◽

Cow's Milk ◽

History Of ◽

Lower Vitamin

Background/Aims: Vitamin D insufficiency is common in children. We aimed to evaluate the main determinants of vitamin D status in Finnish school-aged children, including the history of allergic diseases. Methods: We conducted a cross-sectional study on 171 ten-year-olds where serum 25-hydroxyvitamin D (25[OH]D) levels were measured, and data on food consumption and use of vitamin D supplements were collected. The history of allergic diseases was evaluated with a validated questionnaire. Results: Vitamin D insufficiency (<50 nmol/L) was observed in 16% of the children. In children with a history of cow’s milk allergy, the mean 25(OH)D levels were lower than in children without allergy (60.5 ± 12.6 nmol/L vs. 75.5 ± 22.3 nmol/L, p = 0.004). Lack of vitamin D supplementation, female gender, non-Caucasian ethnicity, and a history of milk allergy were associated with lower vitamin D status. Conclusion: The vitamin D status in our study sample of Finnish schoolchildren was sufficient, which suggests that health policy strategies – such as the recommendation of vitamin D supplementation and the fortification of food products with vitamin D – have been successful in improving vitamin D status in children. Special concern should be given to children with a history of milk allergy to ensure their vitamin D sufficiency.

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