scholarly journals Editorial Expression of Concern: Tumor necrosis factor-inducible gene 6 protein ameliorates chronic liver damage by promoting autophagy formation in mice

2021 ◽  
Author(s):  
Sihyung Wang ◽  
Chanbin Lee ◽  
Jieun Kim ◽  
Jeongeun Hyun ◽  
Minso Lim ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Liver Damage ◽  
Tumor Necrosis ◽  
Chronic Liver ◽  
Chronic Liver Damage ◽  
Necrosis Factor ◽  
Inducible Gene

An Editorial Expression of Concern to this paper has been published: https://doi.org/10.1038/s12276-021-00554-6

scholarly journals Tumor necrosis factor-inducible gene 6 protein ameliorates chronic liver damage by promoting autophagy formation in mice

2017 ◽  
Vol 49 (9) ◽  
pp. e380-e380 ◽  
Author(s):  
Sihyung Wang ◽  
Chanbin Lee ◽  
Jieun Kim ◽  
Jeongeun Hyun ◽  
Minso Lim ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Liver Damage ◽  
Tumor Necrosis ◽  
Chronic Liver ◽  
Chronic Liver Damage ◽  
Necrosis Factor ◽  
Inducible Gene

Tumor-necrosis factor-α induces retinoic acid-inducible gene-I in rheumatoid fibroblast-like synoviocytes

2009 ◽  
Vol 122 (1) ◽  
pp. 89-93 ◽  
Author(s):  
Tadaatsu Imaizumi ◽  
Tomoh Matsumiya ◽  
Hidemi Yoshida ◽  
Takuya Naraoka ◽  
Ryoko Uesato ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Factor Α ◽  
Necrosis Factor ◽  
Fibroblast Like Synoviocytes ◽  
Inducible Gene

scholarly journals Tumor necrosis factor-inducible gene 6 protein: A novel neuroprotective factor against inflammation-induced developmental brain injury

2016 ◽  
Vol 279 ◽  
pp. 283-289 ◽  
Author(s):  
F. Bertling ◽  
I. Bendix ◽  
K. Drommelschmidt ◽  
H.G. Wisniewski ◽  
U. Felderhoff-Mueser ◽  
...  
Keyword(s):  
Brain Injury ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Protein A ◽  
Necrosis Factor ◽  
Inducible Gene

scholarly journals The role of ADAM17 during liver damage

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Mazin Al-Salihi ◽  
Anna Bornikoel ◽  
Yuan Zhuang ◽  
Pawel Stachura ◽  
Jürgen Scheller ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tumor Necrosis Factor ◽  
Liver Injury ◽  
Liver Damage ◽  
Tumor Necrosis ◽  
Cell Damage ◽  
Growth Factor Receptor ◽  
Heparin Binding ◽  
Egfr Ligands ◽  
Necrosis Factor

Abstract A disintegrin and metalloprotease (ADAM) 17 is a membrane bound protease, involved in the cleavage and thus regulation of various membrane proteins, which are critical during liver injury. Among ADAM17 substrates are tumor necrosis factor α (TNFα), tumor necrosis factor receptor 1 and 2 (TNFR1, TNFR2), the epidermal growth factor receptor (EGFR) ligands amphiregulin (AR) and heparin-binding-EGF-like growth factor (HB-EGF), the interleukin-6 receptor (IL-6R) and the receptor for a hepatocyte growth factor (HGF), c-Met. TNFα and its binding receptors can promote liver injury by inducing apoptosis and necroptosis in liver cells. Consistently, hepatocyte specific deletion of ADAM17 resulted in increased liver cell damage following CD95 stimulation. IL-6 trans-signaling is critical for liver regeneration and can alleviate liver damage. EGFR ligands can prevent liver damage and deletion of amphiregulin and HB-EGF can result in increased hepatocyte death and reduced proliferation. All of which indicates that ADAM17 has a central role in liver injury and recovery from it. Furthermore, inactive rhomboid proteins (iRhom) are involved in the trafficking and maturation of ADAM17 and have been linked to liver damage. Taken together, ADAM17 can contribute in a complex way to liver damage and injury.

scholarly journals The molecular cloning and characterization of murine ferritin heavy chain, a tumor necrosis factor-inducible gene.

1988 ◽  
Vol 263 (25) ◽  
pp. 12638-12644 ◽  
Author(s):  
S V Torti ◽  
E L Kwak ◽  
S C Miller ◽  
L L Miller ◽  
G M Ringold ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Molecular Cloning ◽  
Heavy Chain ◽  
Tumor Necrosis ◽  
Ferritin Heavy Chain ◽  
Necrosis Factor ◽  
Inducible Gene
Sign in / Sign up

Export Citation Format

Share Document