Adiposity and cancer: a Mendelian randomization analysis in the UK biobank

2021 ◽  
Author(s):  
Muktar Ahmed ◽  
Anwar Mulugeta ◽  
S. Hong Lee ◽  
Ville-Petteri Mäkinen ◽  
Terry Boyle ◽  
...  
Keyword(s):  
Mendelian Randomization ◽  
Uk Biobank ◽  
Mendelian Randomization Analysis ◽  
The Uk ◽  
Randomization Analysis

scholarly journals Irritable Bowel Syndrome and Migraine: Evidence From Mendelian Randomization Analysis in the UK Biobank

2021 ◽  
Author(s):  
Jie Chen ◽  
Xuejie Chen ◽  
Ying Xie ◽  
Yuhao Sun ◽  
Xiaoyan Wang ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Mendelian Randomization ◽  
Causal Association ◽  
Uk Biobank ◽  
Mendelian Randomization Analysis ◽  
Inverse Variance ◽  
Irritable Bowel ◽  
The Uk ◽  
And Control ◽  
Randomization Analysis

Abstract Background: IBS and Migraine are two diseases featuring high prevalence. Previous studies have suggested a relationship between Irritable Bowel Syndrome (IBS) and migraine, although the causal association remains unclear. We sought to explore the causal association between IBS and migraine, and to prove the importance of migraine prevention in IBS patients.Methods: This study used a two-sample Mendelian-randomization analysis to explore the association of IBS with migraine. Genetic association with migraine were acquired from the UK Biobank (UKB) genetic databases (cases: 1,072; controls: 360,122). We performed estimation using Inverse Variance Weighting (IVW), along with Maximum Likelihood, MR-RAPS, MR-Egger and Weighted Median for sensitivity analysis. Considering possible bias, we also conducted polymorphism, heterogeneity, and directional analysis.Results: The IVW estimation genetically predicted the causal association between IBS and migraine (OR=1.09, 95%CI 1.01 to 1.17, p=0.03). Neither statistical horizontal pleiotropy (MR Egger p=0.42; MR-PRESSO p=0.78) nor possible heterogeneity (IVW Q = 26.15, p=0.80) was found. Reverse causation was also not detected (p steiger<0.01).Conclusion: Mendelian randomization analysis supported a positive-going causal association of IBS with migraine, providing enlightenment for disease prevention and control.

scholarly journals Thyroid Function and Risk of Anemia: A Multivariable-Adjusted and Mendelian Randomization Analysis in the UK Biobank

2021 ◽  
Author(s):  
Nicolien A van Vliet ◽  
Annelies E P Kamphuis ◽  
Wendy P J den Elzen ◽  
Gerard J Blauw ◽  
Jacobijn Gussekloo ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Clinical Diagnosis ◽  
Thyroid Function ◽  
Mendelian Randomization ◽  
Uk Biobank ◽  
Cross Sectional ◽  
Intracellular Regulation ◽  
Clinical Diagnoses ◽  
The Uk ◽  
Randomization Analysis

Abstract Context Thyroid dysfunction is associated with higher anemia prevalence, although causality remains unclear. Objective This study aimed to investigate the association between thyroid function and anemia. Methods This cross-sectional and Mendelian randomization study included 445 482 European participants from the UK Biobank (mean age 56.77 years (SD 8.0); and 54.2% women). Self-reported clinical diagnosis of hypothyroidism was stated by 21 860 (4.9%); self-reported clinical diagnosis of hyperthyroidism by 3431 (0.8%). Anemia, defined as hemoglobin level of &lt; 13 g/dL in men and &lt; 12 g/dL in women, was present in 18 717 (4.2%) participants. Results In cross-sectional logistic regression analyses, self-reported clinical diagnoses of hypo- and hyperthyroidism were associated with higher odds of anemia (OR 1.12; 95% CI, 1.05-1.19 and OR 1.09; 95% CI, 0.91-1.30), although with wide confidence intervals for hyperthyroidism. We did not observe an association of higher or lower genetically influenced thyrotropin (TSH) with anemia (vs middle tertile: OR for lowest tertile 0.98 [95% CI, 0.95-1.02]; highest tertile 1.02 [95% CI, 0.98-1.06]), nor of genetically influenced free thyroxine (fT4) with anemia. Individuals with genetic variants in the DIO3OS gene implicated in intracellular regulation of thyroid hormones had a higher anemia risk (OR 1.05; 95% CI, 1.02-1.10); no association was observed with variants in DIO1 or DIO2 genes. Conclusion While self-reported clinical diagnosis of hypothyroidism was associated with higher anemia risk, we did not find evidence supporting a causal association with variation of thyroid function within the euthyroid range. However, intracellular regulation of thyroid hormones might play a role in developing anemia.

Cigarette Smoking Behavior a Gateway to Opium Use Disorder: A Mendelian Randomization Analysis

2021 ◽  
Author(s):  
Abdolhalim Rajabi ◽  
Azadeh Shojaei ◽  
Leila Janani ◽  
Mojtaba Farjam ◽  
Hamid Reza Baradaran ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Mendelian Randomization ◽  
Smoking Behavior ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis ◽  
Opium Use

scholarly journals Testosterone in Female Depression: A Meta-Analysis and Mendelian Randomization Study

Biomolecules ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 409
Author(s):  
Dhruba Tara Maharjan ◽  
Ali Alamdar Shah Syed ◽  
Guan Ning Lin ◽  
Weihai Ying
Keyword(s):  
Mendelian Randomization ◽  
Meta Analysis ◽  
Menopausal Status ◽  
Serum Testosterone ◽  
Serum Levels ◽  
Testosterone Levels ◽  
Mendelian Randomization Analysis ◽  
The Difference ◽  
Diagnostic Capabilities ◽  
Randomization Analysis

Testosterone’s role in female depression is not well understood, with studies reporting conflicting results. Here, we use meta-analytical and Mendelian randomization techniques to determine whether serum testosterone levels differ between depressed and healthy women and whether such a relationship is casual. Our meta-analysis shows a significant association between absolute serum testosterone levels and female depression, which remains true for the premenopausal group while achieving borderline significance in the postmenopausal group. The results from our Mendelian randomization analysis failed to show any causal relationship between testosterone and depression. Our results show that women with depression do indeed display significantly different serum levels of testosterone. However, the directions of the effect of this relationship are conflicting and may be due to menopausal status. Since our Mendelian randomization analysis was insignificant, the difference in testosterone levels between healthy and depressed women is most likely a manifestation of the disease itself. Further studies could be carried out to leverage this newfound insight into better diagnostic capabilities culminating in early intervention in female depression.

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