scholarly journals Neuroimaging and modulation in obesity and diabetes research: 10th anniversary meeting

Author(s):  
Maren Laughlin ◽  
Bradley Cooke ◽  
Kerri Boutelle ◽  
Cary R. Savage ◽  
Alexxai Kravitz ◽  
...  
2020 ◽  
Vol 21 (13) ◽  
pp. 4773
Author(s):  
Alana Deutsch ◽  
Daorong Feng ◽  
Jeffrey E. Pessin ◽  
Kosaku Shinoda

Adipose tissue is an important regulator of whole-body metabolism and energy homeostasis. The unprecedented growth of obesity and metabolic disease worldwide has required paralleled advancements in research on this dynamic endocrine organ system. Single-cell RNA sequencing (scRNA-seq), a highly meticulous methodology used to dissect tissue heterogeneity through the transcriptional characterization of individual cells, is responsible for facilitating critical advancements in this area. The unique investigative capabilities achieved by the combination of nanotechnology, molecular biology, and informatics are expanding our understanding of adipose tissue’s composition and compartmentalized functional specialization, which underlie physiologic and pathogenic states, including adaptive thermogenesis, adipose tissue aging, and obesity. In this review, we will summarize the use of scRNA-seq and single-nuclei RNA-seq (snRNA-seq) in adipocyte biology and their applications to obesity and diabetes research in the hopes of increasing awareness of the capabilities of this technology and acting as a catalyst for its expanded use in further investigation.


2021 ◽  

Gregory Steinberg completed his PhD at the University of Guelph, Canada, where he studied the role of leptin in muscle in the laboratory of Professor David Dyck. From 2002 to 2006, Greg was a postdoctoral fellow with Professor Bruce Kemp at St Vincent’s Institute of Medical Research, Australia, where he studied the role of the AMP-activated protein kinase (AMPK). In 2006, he started his academic career as Lecturer, Senior Research Fellow and Head of Metabolism at St Vincent’s Institute and the University of Melbourne. He returned to Canada in 2009 where his research studies cellular energy sensing mechanisms and looks at how endocrine factors, lipid metabolism and insulin sensitivity are linked and contribute to the development of obesity, type 2 diabetes, cardiovascular disease and cancer. He is the recipient of numerous awards, including the Diabetes Canada-Canadian Institutes of Health Research, Diabetes Young Scientist Award; the Endocrine Society Richard E Weitzman Outstanding Early Career Investigator Award; the Canadian Institutes of Health Research Gold Leaf Prize; and the American Diabetes Association Outstanding Scientific Achievement Award. To help celebrate the 100th anniversary of the discovery of insulin, Greg also recently took part in Diabetes Canada’s fitness fundraiser, ‘Lace Up for Diabetes’, riding 8000 km (the equivalent of crossing Canada) over a period of 80 days and raising almost $15,000 to help fund the next breakthrough discovery in the field. Coinciding with our issue theme of diabetes, which also marks the centenary of this discovery by Canadian scientists, The Biochemist spoke to Greg briefly about his work in this area.


2011 ◽  
Vol 5 (2) ◽  
pp. 212-224 ◽  
Author(s):  
Abby G. Ershow ◽  
Charles M. Peterson ◽  
William T. Riley ◽  
Albert Skip Rizzo ◽  
Brian Wansink

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