αSMA+ fibroblasts suppress Lgr5+ cancer stem cells and restrain colorectal cancer progression

Oncogene ◽  
2021 ◽  
Author(s):  
Kathleen M. McAndrews ◽  
Karina Vázquez-Arreguín ◽  
Changsoo Kwak ◽  
Hikaru Sugimoto ◽  
Xiaofeng Zheng ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cancer Progression ◽  
Colorectal Cancer Progression

scholarly journals Mesenchymal stem cells promote colorectal cancer progression through AMPK/mTOR-mediated NF-κB activation

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Xiao-Bing Wu ◽  
Yang Liu ◽  
Gui-Hua Wang ◽  
Xiao Xu ◽  
Yang Cai ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cancer Progression ◽  
Colorectal Cancer Progression

Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression through paracrine neuregulin 1/HER3 signalling

Gut ◽  
2012 ◽  
Vol 62 (4) ◽  
pp. 550-560 ◽  
Author(s):  
Astrid De Boeck ◽  
Patrick Pauwels ◽  
Karen Hensen ◽  
Jean-Luc Rummens ◽  
Wendy Westbroek ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Cancer Progression ◽  
Neuregulin 1 ◽  
Colorectal Cancer Progression

scholarly journals Stem cells as therapeutic targets in colorectal cancer

2021 ◽  
Vol 18 (2) ◽  
pp. 171-183
Author(s):  
Alicja Zalewski ◽  
Adam E Snook ◽  
Scott A Waldman
Keyword(s):  
Public Health ◽  
Colorectal Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cancer Progression ◽  
Tumor Initiating Cells ◽  
Men And Women ◽  
The Us ◽  
Significant Burden ◽  
Colorectal Cancer Stem Cells

Colorectal cancer continues to represent a significant burden on public health as the second highest cause of cancer mortality, when men and women are combined, in the US. About 50% of patients either present with late-stage metastatic disease, or develop metastatic recurrences, and ultimately die. In turn, this mortality largely reflects cancer stem cells, tumor-initiating cells that are responsible for cancer progression, drug resistance, recurrence and metastasis. This review summarizes the unique properties of colorectal cancer stem cells, and the emerging strategies by which they can be selectively targeted as a therapeutic approach to eradicating this disease.

scholarly journals Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression via CCR5

2019 ◽  
Vol 10 (4) ◽  
Author(s):  
Gen Nishikawa ◽  
Kenji Kawada ◽  
Jun Nakagawa ◽  
Kosuke Toda ◽  
Ryotaro Ogawa ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Cancer Progression ◽  
Colorectal Cancer Progression
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