Does the use of plasma rich in growth factors (PRGF) produce benefits for patients with chronic periodontal disease in non-surgical treatment?

Introduction. Photodynamic therapy is supportive method of non-surgical treatment of periodontitis. The aim of the study was the assessment of photodynamic therapy impact on periodontal disease clinical parameters with a particular emphasis on microbiological aspects during periodontal treatment. Material and methods. The research was conducted on seven healthy patients aged 26- 55 years. All the patients were treated with a non-surgical (SRP) periodontal treatment. Then, the assisted photodynamic therapy was applied in selected pockets. Samples of the material obtained from periodontal pockets before and after the treatment were cultured in a microbiological laboratory. Results. After the introduced therapy the clinical improvement of periodontal disease was observed in the majority (6/7) of patients taking part in the study. There obtained the elimination of inflammation to 85.7% of the patients. Periodontal pocket depths have deteriorated from 0.5 to 3.0 mm in comparison to the pre-treatment values. The overall number of bacteria compared to the pre-treatment value was reduced. In addition, there was noticed a decrease in the number of periopathogens. Control samples showed a vivid dominance of the physiological flora. Conclusions. The non-surgical treatment of periodontitis in combination with the supportive action of photodynamic therapy has promising therapeutic effects by reducing the inflammation and decreasing the depth of periodontal pockets. The change in the ratio of periopathogens to physiological flora may indicate the restoration and maintenance of the state balance in periodontal pockets for patients with periodontitis.

Download Full-text

Healing following surgical non-surgical treatment of periodontal disease. A clinical study

Journal Of Clinical Periodontology ◽

10.1111/j.1600-051x.1982.tb01227.x ◽

1982 ◽

Vol 9 (2) ◽

pp. 115-128 ◽

Cited By ~ 271

Author(s):

Jan Lindhe ◽

Elisabeth Westfelt ◽

Sture Nyman ◽

Sigmund S. Socransky ◽

Lars Heijl ◽

...

Keyword(s):

Clinical Study ◽

Surgical Treatment ◽

Periodontal Disease ◽

Non Surgical Treatment

Download Full-text

Effectiveness of non-surgical treatment to reduce il-18 levels in the gingival crevicular fluid of patients with periodontal disease

Brazilian Dental Journal ◽

10.1590/s0103-64402012000400020 ◽

2012 ◽

Vol 23 (4) ◽

pp. 428-432 ◽

Cited By ~ 6

Author(s):

Bernardo Oliveira de Campos ◽

Ricardo Guimarães Fischer ◽

Anders Gustafsson ◽

Carlos Marcelo da Silva Figueredo

Keyword(s):

Surgical Treatment ◽

Periodontal Disease ◽

Gingival Crevicular Fluid ◽

Gingival Index ◽

Pocket Depth ◽

Probing Pocket Depth ◽

Crevicular Fluid ◽

Attachment Level ◽

Gingival Fluid ◽

Non Surgical Treatment

The aim of this study was to evaluate the effectiveness of the non-surgical periodontal treatment in reducing the gingival crevicular fluid (GCF) levels of IL-18 from inflamed periodontal sites. Fourteen patients with periodontal disease were included, being 9 patients with chronic periodontitis (mean age: 48.8 SD ± 7.4 years) and 5 patients with gingivitis (mean age: 43.6 SD ± 11.8). The patients were divided in the following groups: gingivitis sites from periodontitis patients (sites GP), periodontitis sites from periodontitis patients (sites PP), and gingivitis sites from gingivitis patients (sites GG). Probing pocket depth (PPD), probing attachment level (AL), plaque index (PI) and gingival index (GI) were recorded, and gingival fluid samples were collected. The subjects received non-surgical treatment and were re-evaluated 30 days after treatment (day 30 AT). There was a significant reduction in PI in GG (1.0 ± 0.4 to 0.5 ± 0.2), GP (1.2 ± 0.3 to 0.5 ± 0.3), and in PP (1.3 ± 0.4 to 0.7 ± 0.3) 30 AT. There was also a significant reduction in the GI in GG (1.3 ± 0.3 to 0.7 ± 0.4). PPD reduced significantly in GG (2.4 ± 0.6 to 1.9 ± 0.1), and PP (6.7 ± 1.1 to 5.2 ± 0.9) 30 AT. When all the samples were analyzed together, there was a significant reduction in IL-18 (12.9 ± 7.2 to 10.0 ± 3.1). This study showed that non-surgical treatment was effective in reducing GCF levels of IL-18 from inflamed periodontal sites.

Download Full-text

Longitudinal Comparisons of the Periodontal Status of Patients with Moderate to Severe Periodontal Disease Receiving No Treatment, Non-Surgical Treatment, and Surgical Treatment Utilizing Individual Sites for Analysis

Journal of Periodontology ◽

10.1902/jop.2001.72.11.1509 ◽

2001 ◽

Vol 72 (11) ◽

pp. 1509-1519 ◽

Cited By ~ 44

Author(s):

Stephen K. Harrel ◽

Martha E. Nunn

Keyword(s):

Surgical Treatment ◽

Periodontal Disease ◽

Periodontal Status ◽

Severe Periodontal Disease ◽

Non Surgical Treatment

Download Full-text

Azithromycin in Periodontal Therapy: Beyond the Antibiotics

Journal of Nepalese Society of Periodontology and Oral Implantology ◽

10.3126/jnspoi.v2i2.23616 ◽

2018 ◽

Vol 2 (2) ◽

pp. 61-66

Author(s):

Vijendra Pal Singh ◽

Sangeeta Umesh Nayak ◽

Sunil Kumar Nettemu ◽

Sowmya Nettem ◽

Yen Hui Lee ◽

...

Keyword(s):

Surgical Treatment ◽

Side Effects ◽

Literature Review ◽

Periodontal Disease ◽

Multifactorial Disease ◽

Scaling And Root Planing ◽

Antibiotic Property ◽

Dosage Regime ◽

Plaque Biofilm ◽

Non Surgical Treatment

Periodontitis is a multifactorial disease, in which microorganisms in plaque biofilm play a major role. Scaling and root planing is the primary mode of non-surgical treatment for periodontal disease. Adjunctive use of an antimicrobial is advocated in certain periodontal disease conditions. Azithromycin might be considered a promising adjunctive drug in the treatment for periodontal disease because of its distinguished characteristic of immunomodulation, anti-inflammatory and antibiotic property along with the accumulation in higher concentration into the acute reactant cells and sustained release at the site of infection. This antibiotic is popular for its very simple dosage regime and limited side effects. The objective of this literature review to highlight the mechanism and potential favourable role in the management of various form of the periodontal disease.

Download Full-text