scholarly journals Azithromycin in Periodontal Therapy: Beyond the Antibiotics

2018 ◽  
Vol 2 (2) ◽  
pp. 61-66
Author(s):  
Vijendra Pal Singh ◽  
Sangeeta Umesh Nayak ◽  
Sunil Kumar Nettemu ◽  
Sowmya Nettem ◽  
Yen Hui Lee ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Side Effects ◽  
Literature Review ◽  
Periodontal Disease ◽  
Multifactorial Disease ◽  
Scaling And Root Planing ◽  
Antibiotic Property ◽  
Dosage Regime ◽  
Plaque Biofilm ◽  
Non Surgical Treatment

Periodontitis is a multifactorial disease, in which microorganisms in plaque biofilm play a major role. Scaling and root planing is the primary mode of non-surgical treatment for periodontal disease. Adjunctive use of an antimicrobial is advocated in certain periodontal disease conditions. Azithromycin might be considered a promising adjunctive drug in the treatment for periodontal disease because of its distinguished characteristic of immunomodulation, anti-inflammatory and antibiotic property along with the accumulation in higher concentration into the acute reactant cells and sustained release at the site of infection. This antibiotic is popular for its very simple dosage regime and limited side effects. The objective of this literature review to highlight the mechanism and potential favourable role in the management of various form of the periodontal disease.

Long-term effect of surgical/non-surgical treatment of periodontal disease

1984 ◽  
Vol 11 (7) ◽  
pp. 448-458 ◽  
Author(s):  
J. Lindhe ◽  
E. Westfelt ◽  
S. Nyman ◽  
S. S. Socransky ◽  
A. D. Haffajee
Keyword(s):  
Surgical Treatment ◽  
Periodontal Disease ◽  
Term Effect ◽  
Long Term Effect ◽  
Non Surgical Treatment

scholarly journals Radiotherapy for subependymal giant cell astrocytoma: time to challenge a historical ban? Case report and review of the literature.

2020 ◽  
Author(s):  
Randa Kamel ◽  
Dirk Leon Van den Berge
Keyword(s):  
Brain Tumor ◽  
Surgical Treatment ◽  
Side Effects ◽  
Giant Cell ◽  
Stereotactic Radiotherapy ◽  
Tumor Control ◽  
Subependymal Giant Cell Astrocytoma ◽  
Fractionated Radiotherapy ◽  
Non Surgical Treatment ◽  
Giant Cell Astrocytoma

Abstract Background Subependymal giant cell astrocytoma is a deep-seated benign but life-threatening brain tumor that occurs in patients with the tuberous sclerosis complex. Resection is the traditional treatment and expert opinion is strongly against the use of radiotherapy. Systematic epidemiological studies, however, demonstrate high rates of complications and recurrences. The need for efficient non-surgical treatment is best illustrated by the considerable enthusiasm about the activity of the mTOR inhibitor everolimus in reducing tumor volume. Unfortunately regrowth is frequent after dose reduction or cessation and continued tumor control requires continued administration of the drug, leading to concerns about its metabolic and immunosuppressive side effects and cost of treatment. Results We successfully treated a case with growing bilateral subependymal giant cell astrocytoma with fractionated stereotactic radiotherapy before everolimus became available. After a follow-up of 8 years, everolimus was administered for renal angiomyolipoma and the patient was followed up until 13 years after radiotherapy. Successive MRI's demonstrated an 80% volume reduction after radiotherapy that further increased to 90% during everolimus administration. In order to review the basis for the strong expert opinion against radiotherapy, we performed an exhaustive literature study regarding efficiency, potential dangers and side effects of radiation. 1298 article references and 780 full-text articles in search of evidence for contra-indicating radiotherapy. Varying short-term tumor control of single-fraction radiosurgery were described in a total of 13 cases. Only in two published cases the radiation dose of fractionated radiotherapy was mentioned. A single publication mentions an induced secondary brain tumor 8 years after total brain irradiation. Conclusion There is no evidence for contra-indicating fractionated radiotherapy in subependymal giant cell astrocytoma. Our experience demonstrates that these tumors, as other benign intracranial tumors, responds slowly to radiotherapy and suggests that fractionated stereotactic radiotherapy holds promise to consolidate responses obtained with mTOR inhibitors avoiding regrowth after cessation. This combined treatment would avoid costs and complications of long-term treatment with everolimus and deserves to be studied as a definitive non-surgical treatment.

scholarly journals Analysis of clinical and microbiological results of photodynamic therapy as support in non-surgical treatment of periodontitis – preliminary study

2019 ◽  
pp. 35-41
Author(s):  
Adrian Maj ◽  
Aida Kusiak ◽  
Katarzyna Garbacz ◽  
Marta Ziółkowska-Klinkosz
Keyword(s):  
Photodynamic Therapy ◽  
Surgical Treatment ◽  
Periodontal Disease ◽  
Periodontal Treatment ◽  
Periodontal Pocket ◽  
Therapeutic Effects ◽  
Before And After ◽  
Microbiological Laboratory ◽  
Pre Treatment ◽  
Non Surgical Treatment

Introduction. Photodynamic therapy is supportive method of non-surgical treatment of periodontitis. The aim of the study was the assessment of photodynamic therapy impact on periodontal disease clinical parameters with a particular emphasis on microbiological aspects during periodontal treatment. Material and methods. The research was conducted on seven healthy patients aged 26- 55 years. All the patients were treated with a non-surgical (SRP) periodontal treatment. Then, the assisted photodynamic therapy was applied in selected pockets. Samples of the material obtained from periodontal pockets before and after the treatment were cultured in a microbiological laboratory. Results. After the introduced therapy the clinical improvement of periodontal disease was observed in the majority (6/7) of patients taking part in the study. There obtained the elimination of inflammation to 85.7% of the patients. Periodontal pocket depths have deteriorated from 0.5 to 3.0 mm in comparison to the pre-treatment values. The overall number of bacteria compared to the pre-treatment value was reduced. In addition, there was noticed a decrease in the number of periopathogens. Control samples showed a vivid dominance of the physiological flora. Conclusions. The non-surgical treatment of periodontitis in combination with the supportive action of photodynamic therapy has promising therapeutic effects by reducing the inflammation and decreasing the depth of periodontal pockets. The change in the ratio of periopathogens to physiological flora may indicate the restoration and maintenance of the state balance in periodontal pockets for patients with periodontitis.

Healing following surgical non-surgical treatment of periodontal disease. A clinical study

1982 ◽  
Vol 9 (2) ◽  
pp. 115-128 ◽  
Author(s):  
Jan Lindhe ◽  
Elisabeth Westfelt ◽  
Sture Nyman ◽  
Sigmund S. Socransky ◽  
Lars Heijl ◽  
...  
Keyword(s):  
Clinical Study ◽  
Surgical Treatment ◽  
Periodontal Disease ◽  
Non Surgical Treatment

scholarly journals Effectiveness of non-surgical treatment to reduce il-18 levels in the gingival crevicular fluid of patients with periodontal disease

2012 ◽  
Vol 23 (4) ◽  
pp. 428-432 ◽  
Author(s):  
Bernardo Oliveira de Campos ◽  
Ricardo Guimarães Fischer ◽  
Anders Gustafsson ◽  
Carlos Marcelo da Silva Figueredo
Keyword(s):  
Surgical Treatment ◽  
Periodontal Disease ◽  
Gingival Crevicular Fluid ◽  
Gingival Index ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Crevicular Fluid ◽  
Attachment Level ◽  
Gingival Fluid ◽  
Non Surgical Treatment

The aim of this study was to evaluate the effectiveness of the non-surgical periodontal treatment in reducing the gingival crevicular fluid (GCF) levels of IL-18 from inflamed periodontal sites. Fourteen patients with periodontal disease were included, being 9 patients with chronic periodontitis (mean age: 48.8 SD ± 7.4 years) and 5 patients with gingivitis (mean age: 43.6 SD ± 11.8). The patients were divided in the following groups: gingivitis sites from periodontitis patients (sites GP), periodontitis sites from periodontitis patients (sites PP), and gingivitis sites from gingivitis patients (sites GG). Probing pocket depth (PPD), probing attachment level (AL), plaque index (PI) and gingival index (GI) were recorded, and gingival fluid samples were collected. The subjects received non-surgical treatment and were re-evaluated 30 days after treatment (day 30 AT). There was a significant reduction in PI in GG (1.0 ± 0.4 to 0.5 ± 0.2), GP (1.2 ± 0.3 to 0.5 ± 0.3), and in PP (1.3 ± 0.4 to 0.7 ± 0.3) 30 AT. There was also a significant reduction in the GI in GG (1.3 ± 0.3 to 0.7 ± 0.4). PPD reduced significantly in GG (2.4 ± 0.6 to 1.9 ± 0.1), and PP (6.7 ± 1.1 to 5.2 ± 0.9) 30 AT. When all the samples were analyzed together, there was a significant reduction in IL-18 (12.9 ± 7.2 to 10.0 ± 3.1). This study showed that non-surgical treatment was effective in reducing GCF levels of IL-18 from inflamed periodontal sites.

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