Case Studies Within Psychotherapy Trials: Integrating Qualitative and Quantitative Methods presents a specific, mixed-methods approach, called the “Cases Within Trials” (CWT) model, to psychotherapy research, combining the results from a randomized clinical trial (RCT) with systematic case studies involving contrasting outcomes drawn from the experimental condition of the RCT; and a synthesis of the two types of knowledge. Chapters 3–6 of the book present four specific and diverse projects that concretely illustrate the CWT method. In Chapter 8 the editors analyze the four chapters and explore emergent themes in the knowledge gained from them. In the process, the editors systematically compare the positive-outcome and negative-outcome cases across the four projects, highlighting, for example, (a) the importance of contextual variables in creating the conditions for change mechanisms to be activated; (b) the multidimensional, reciprocally interactional nature of the therapy process; and (c) the particular role of therapist responsiveness.