scholarly journals Three-dimensional microenvironmental priming of human mesenchymal stem cells in hydrogels facilitates efficient and rapid retroviral gene transduction via accelerated cell cycle synchronization

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Yein Lee ◽  
Yoshie Arai ◽  
Jinsung Ahn ◽  
Deogil Kim ◽  
Seunghee Oh ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Three Dimensional ◽  
Human Mesenchymal Stem Cells ◽  
Gene Transduction ◽  
Cell Cycle Synchronization

Effect of Purmorphamine on Osteogenic Differentiation of Human Mesenchymal Stem Cells in a Three-Dimensional Dynamic Culture System

2014 ◽  
Vol 7 (4) ◽  
pp. 575-584 ◽  
Author(s):  
Faezeh Faghihi ◽  
Adam Papadimitropoulos ◽  
Ivan Martin ◽  
Mohamadreza Baghaban Eslaminejad
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Culture System ◽  
Three Dimensional ◽  
Human Mesenchymal Stem Cells ◽  
Dynamic Culture

scholarly journals Three-dimensional carbon nanotube scaffolds for long-term maintenance and expansion of human mesenchymal stem cells

2017 ◽  
Vol 105 (7) ◽  
pp. 1927-1939 ◽  
Author(s):  
Gaurav Lalwani ◽  
Michael D'agati ◽  
Anu Gopalan ◽  
Sunny C. Patel ◽  
Yahfi Talukdar ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Carbon Nanotube ◽  
Three Dimensional ◽  
Human Mesenchymal Stem Cells ◽  
Term Maintenance

scholarly journals Three-dimensional printed polymeric system to encapsulate human mesenchymal stem cells differentiated into islet-like insulin-producing aggregates for diabetes treatment

2016 ◽  
Vol 7 ◽  
pp. 204173141663819 ◽  
Author(s):  
Omaima M Sabek ◽  
Marco Farina ◽  
Daniel W Fraga ◽  
Solmaz Afshar ◽  
Andrea Ballerini ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Three Dimensional ◽  
Human Mesenchymal Stem Cells ◽  
Diabetes Treatment ◽  
Polymeric System

scholarly journals Three-dimensional graphene foams promote osteogenic differentiation of human mesenchymal stem cells

Nanoscale ◽  
2013 ◽  
Vol 5 (10) ◽  
pp. 4171 ◽  
Author(s):  
Spencer W. Crowder ◽  
Dhiraj Prasai ◽  
Rutwik Rath ◽  
Daniel A. Balikov ◽  
Hojae Bae ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Three Dimensional ◽  
Human Mesenchymal Stem Cells ◽  
Graphene Foams

scholarly journals Three-dimensional hypoxic culture of human mesenchymal stem cells encapsulated in a photocurable, biodegradable polymer hydrogel: A potential injectable cellular product for nucleus pulposus regeneration

2014 ◽  
Vol 10 (8) ◽  
pp. 3463-3474 ◽  
Author(s):  
Deepak Kumar ◽  
Irini Gerges ◽  
Margherita Tamplenizza ◽  
Cristina Lenardi ◽  
Nicholas R. Forsyth ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Nucleus Pulposus ◽  
Biodegradable Polymer ◽  
Three Dimensional ◽  
Human Mesenchymal Stem Cells ◽  
Polymer Hydrogel

scholarly journals Reactive Oxygen Species Are Required for Human Mesenchymal Stem Cells to Initiate Proliferation after the Quiescence Exit

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
O. G. Lyublinskaya ◽  
Ya. G. Borisov ◽  
N. A. Pugovkina ◽  
I. S. Smirnova ◽  
Ju. V. Obidina ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Cycle ◽  
Stem Cells ◽  
Cell Proliferation ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Human Mesenchymal Stem Cells ◽  
S Phase ◽  
Oxygen Species ◽  
Antioxidant Treatment

The present study focuses on the involvement of reactive oxygen species (ROS) in the process of mesenchymal stem cells “waking up” and entering the cell cycle after the quiescence. Using human endometrial mesenchymal stem cells (eMSCs), we showed that intracellular basal ROS level is positively correlated with the proliferative status of the cell cultures. Our experiments with the eMSCs synchronized in the G0phase of the cell cycle revealed a transient increase in the ROS level upon the quiescence exit after stimulation of the cell proliferation. This increase was registered before the eMSC entry to the S-phase of the cell cycle, and elimination of this increase by antioxidants (N-acetyl-L-cysteine, Tempol, and Resveratrol) blocked G1–S-phase transition. Similarly, a cell cycle arrest which resulted from the antioxidant treatment was observed in the experiments with synchronized human mesenchymal stem cells derived from the adipose tissue. Thus, we showed that physiologically relevant level of ROS is required for the initiation of human mesenchymal stem cell proliferation and that low levels of ROS due to the antioxidant treatment can block the stem cell self-renewal.

scholarly journals Light-activated gene transduction of recombinant adeno-associated virus in human mesenchymal stem cells

Gene Therapy ◽  
2003 ◽  
Vol 11 (1) ◽  
pp. 34-41 ◽  
Author(s):  
H Ito ◽  
JJ Goater ◽  
P Tiyapatanaputi ◽  
PT Rubery ◽  
RJ O'Keefe ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
Gene Transduction ◽  
Adeno Associated Virus
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