scholarly journals Report from a multidisciplinary meeting on anxiety as a non-motor manifestation of Parkinson’s disease

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Gregory M. Pontone ◽  
Nadeeka Dissanayaka ◽  
Liana Apostolova ◽  
Richard G. Brown ◽  
Roseanne Dobkin ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Expert Panel ◽  
Motor Impairment ◽  
Future Research ◽  
Severe Problem ◽  
High Prevalence ◽  
Expert Meeting ◽  
Clinician Scientist

AbstractAnxiety is a severe problem for at least one-third of people living with Parkinson’s disease (PD). Anxiety appears to have a greater adverse impact on quality of life than motor impairment. Despite its high prevalence and impact on daily life, anxiety is often undiagnosed and untreated. To better address anxiety in PD, future research must improve knowledge about the mechanism of anxiety in PD and address the lack of empirical evidence from clinical trials. In response to these challenges, the Parkinson’s Foundation sponsored an expert meeting on anxiety on June 13th and 14th 2018. This paper summarizes the findings from that meeting informed by a review of the existing literature and discussions among patients, caregivers, and an international, clinician-scientist, expert panel working group. The goal is to provide recommendations to improve our understanding and treatment of anxiety in PD.

scholarly journals Which measures of physical function and motor impairment best predict quality of life in Parkinson’s disease?

2011 ◽  
Vol 17 (9) ◽  
pp. 693-697 ◽  
Author(s):  
T. Ellis ◽  
J.T. Cavanaugh ◽  
G.M. Earhart ◽  
M.P. Ford ◽  
K.B. Foreman ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Physical Function ◽  
Motor Impairment

scholarly journals Efficacy of osteopathic manipulative treatment in patients with Parkinson’s disease: a narrative review

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Raymond Li ◽  
Ann Jose ◽  
Jessica Poon ◽  
Cindy Zou ◽  
Maria Istafanos ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Function ◽  
Manual Therapy ◽  
Symptom Management ◽  
Future Research ◽  
Osteopathic Manipulative Treatment ◽  
Literature Searches

Abstract Context Parkinson’s disease (PD) is a neurodegenerative disease that leads to impaired motor and non-motor function in patients. PD is non-curative and gradually reduces quality of life, leading patients to seek treatment for symptom management. Osteopathic manipulative treatment (OMT) applies the biomechanical, neurologic, circulatory, metabolic, and psychosocial models in approaching and treating the major symptomatology of PD patients. Objectives This article evaluates the literature published in the past 10 years analyzing evidence on OMT and its functional application on gait, balance, motor function, bradykinesia, and autonomic dysfunctions, and to identify promising avenues for further investigation. Methods The authors obtained studies from the research databases MEDLINE/PubMed, ScienceDaily, and EBSCO, as well as the Journal of American Osteopathic Association’s published archives. Searches were conducted in December 2020 utilizing the search phrases “OMM” (osteopathic manipulative medicine), “OMT,” “osteopathic,” “Parkinson Disease,” “manual therapy,” “physical therapy,” “training,” “autonomics,” “gait,” and “balance.” Articles published between 2010 and 2021 including subjects with Parkinson’s disease and the use of OMT or any other form of manual therapy were included. Five authors independently performed literature searches and methodically resolved any disagreements over article selection together. Results There were a total of 10,064 hits, from which 53 articles were considered, and five articles were selected based on the criteria. Conclusions The progressive nature of PD places symptom management on the forefront of maintaining patients’ quality of life. OMT has demonstrated the greatest efficacy on managing motor-related and neurologic symptoms and assists in treating the greater prevalence of somatic dysfunctions that arise from the disease. Research in this field remains limited and should be the target of future research.

scholarly journals A Multimodal Approach to the Quantification of Kinetic Tremor in Parkinson’s Disease

Sensors ◽  
2019 ◽  
Vol 20 (1) ◽  
pp. 184
Author(s):  
Mateusz Szumilas ◽  
Krzysztof Lewenstein ◽  
Elżbieta Ślubowska ◽  
Stanisław Szlufik ◽  
Dariusz Koziorowski
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Expert Knowledge ◽  
Motor Impairment ◽  
Kinetic Tremor ◽  
Model Predictions ◽  
Model Ensembles ◽  
Selection Operator ◽  
Lasso Method

Parkinson’s disease results in motor impairment that deteriorates patients’ quality of life. One of the symptoms negatively interfering with daily activities is kinetic tremor which should be measured to monitor the outcome of therapy. A new instrumented method of quantification of the kinetic tremor is proposed, based on the analysis of circles drawn on a digitizing tablet by a patient. The aim of this approach is to obtain a tremor scoring equivalent to that performed by trained clinicians. Models are trained with the least absolute shrinkage and selection operator (LASSO) method to predict the tremor scores on the basis of the parameters computed from the patients’ drawings. Signal parametrization is derived from both expert knowledge and the response of an artificial neural network to the raw data, thus the approach was named multimodal. The fitted models are eventually combined into model ensembles that provide aggregated scores of the kinetic tremor captured in the drawings. The method was verified with a set of clinical data acquired from 64 Parkinson’s disease patients. Automated and objective quantification of the kinetic tremor with the presented approach yielded promising results, as the Pearson’s correlations between the visual ratings of tremor and the model predictions ranged from 0.839 to 0.890 in the best-performing models.

scholarly journals Telerehabilitation for Communication and Swallowing Disorders in Parkinson’s Disease

2021 ◽  
pp. 1-6
Author(s):  
Deborah Theodoros
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
New Technologies ◽  
Negative Impact ◽  
Swallowing Disorders ◽  
Future Research ◽  
Patient Centered ◽  
Language Pathology

Communication and swallowing disorders are highly prevalent in people with Parkinson’s disease (PD). The negative impact of these disorders on the quality of life of the person with PD and their families cannot be underestimated. Despite a demand for speech-language pathology services to support people with PD, many barriers to services exist. Telerehabilitation provides an alternate and complementary approach to in-person therapy that is patient-centered, enables timely assessment and intervention, and facilitates continuity of care throughout the course of the disease. This review explores the telerehabilitation applications designed for the management of the communication and swallowing disorders in PD, addresses the benefits and challenges of telerehabilitation, identifies future research directions, and highlights the potential of new technologies to enhance the management of communication and swallowing disorders and quality of life for people with PD.

scholarly journals Predictors of clinically significant quality of life impairment in Parkinson’s disease

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Santos García D. ◽  
Teresa de Deus Fonticoba ◽  
Carlos Cores ◽  
Guillermo Muñoz ◽  
Jose M. Paz González ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Independent Living ◽  
Motor Impairment ◽  
Control Group ◽  
Health Related Qol ◽  
Clinically Significant

AbstractQuality of life (QOL) plays an important role in independent living in Parkinson’s disease (PD) patients, being crucial to know what factors impact QoL throughout the course of the disease. Here we identified predictors of QoL impairment in PD patients from a Spanish cohort. PD patients recruited from 35 centers of Spain from the COPPADIS cohort from January 2016, to November 2017, were followed up during 2 years. Health-related QoL (HRQoL) and global QoL (GQoL) were assessed with the 39-item Parkinson’s disease Questionnaire (PDQ-39) and the EUROHIS-QOL 8-item index (EUROHIS-QOL8), respectively, at baseline (V0) and at 24 months ± 1 month (V2). Clinically significant QoL impairment was defined as presenting an increase (PDQ-39SI) or decrement (EUROHIS-QOL8) at V2 ≥ 10% of the score at baseline (V0). A comparison with a control group was conducted for GQoL. GQoL did not change significantly in PD patients (N = 507; p = 0.686) or in the control group (N = 119; p = 0.192). The mean PDQ-39SI was significantly increased in PD patients (62.7 ± 8.5 years old; 58.8% males; N = 500) by 21.6% (from 16.7 ± 13 to 20.3 ± 16.4; p < 0.0001) at V2. Ninety-three patients (18.6%) presented a clinically significant HRQoL impairment at V2. To be younger (OR = 0.896; 95% CI 0.829–0.968; p = 0.006), to be a female (OR = 4.181; 95% CI 1.422–12.290; p = 0.009), and to have a greater increase in BDI-II (Beck Depression Inventory-II) (OR = 1.139; 95% CI 1.053–1.231; p = 0.001) and NMSS (Non-Motor Symptoms Scale) (OR = 1.052; 95% CI 1.027–1.113; p < 0.0001) total scores from V0 to V2 were associated with clinically significant HRQoL impairment at the 2-year follow-up (Hosmer–Lemeshow test, p = 0.665; R2 = 0.655). An increase in ≥5 and ≥10 points of BDI-II and NMSS total score at V2 multiplied the probability of presenting clinically significant HRQoL impairment by 5 (OR = 5.453; 95% CI 1.663–17.876; p = 0.005) and 8 (OR = 8.217; 95% CI, 2.975–22.696; p = 0.002), respectively. In conclusion, age, gender, mood, and non-motor impairment were associated with clinically significant HRQoL impairment after the 2-year follow-up in PD patients.

Effects of Ai Chi on balance, quality of life, functional mobility, and motor impairment in patients with Parkinson’s disease

2017 ◽  
Vol 40 (7) ◽  
pp. 791-797 ◽  
Author(s):  
Emine Eda Kurt ◽  
Buket Büyükturan ◽  
Öznur Büyükturan ◽  
Hatice Rana Erdem ◽  
Figen Tuncay
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Impairment ◽  
Functional Mobility

Distribution of motor impairment influences quality of life in Parkinson's disease

2008 ◽  
Vol 23 (10) ◽  
pp. 1466-1468 ◽  
Author(s):  
Kim C. Stewart ◽  
Hubert H. Fernandez ◽  
Michael S. Okun ◽  
Charles E. Jacobson ◽  
Chris J. Hass
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Impairment

scholarly journals The association between frailty and Parkinson’s disease in the ReSPOnD trial

2021 ◽  
Vol 24 (1) ◽  
pp. 22-25
Author(s):  
Natalie Smith ◽  
Daisy M. Gaunt ◽  
Alan Whone ◽  
Yoav Ben-Shlomo ◽  
Emily J. Henderson
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Depression Score ◽  
Future Research ◽  
Double Blind ◽  
Frailty Status ◽  
High Prevalence ◽  
Updrs Score ◽  
Randomised Controlled

Background: Frailty and Parkinson’s disease (PD) are both highly prevalent in older people, but few studies have studied frailty in people with Parkinson’s. Identifying frailty in this population is vital, to target new interventions to those who would most benefit. Methods:  Data were collected as part of the double-blind randomised controlled rivastigmine to stabilise gait ReSPonD trial in 130 people with Hoehn and Yahr 2-3, idiopathic PD who had fallen in the year prior to enrolment.  Individuals were assessed at baseline and followed up at 8 months, including determination of frailty status.     Results: 120 patients attended for follow-up.  At follow-up, the mean (SD) age was 70.2 years (8.0) and MDS-UPDRS total score 91.5 (29.1). Median disease duration was 9.2 years (IQR 4.6 to 13.1), Geriatric Depression Score 4 (IQR 2 to 6). Using the Fried frailty criteria, 31 (26%) were frail and 70 (58%) pre-frail.  In univariable analysis, being female, higher depression score and MDS-UPDRS score was associated with greater frailty. Using ordinal regression, in the multivariable model, being female (Odds ratio [OR] 3.10, 95%CI 1.53 to 6.26, p=0.002), higher total MDS-UPDRS score (OR 2.02, 95%CI 1.42 to 2.87, p<0.0001) and higher depression (OR 1.47, 95%CI 1.05 to 2.06, p=0.03) were associated with higher number of frailty markers. Conclusion: There was a high prevalence (84%) of pre-frail and frail individuals in patients participating in this RCT. Future research should determine the optimum tool to assess frailty in this at-risk population and delineate the association between Parkinson’s, frailty and health outcomes.

Application of telehealth intervention in Parkinson’s disease: A systematic review and meta-analysis

2018 ◽  
Vol 26 (1-2) ◽  
pp. 3-13 ◽  
Author(s):  
Yan-Ya Chen ◽  
Bing-Sheng Guan ◽  
Ze-Kai Li ◽  
Qiao-Hong Yang ◽  
Tian-Jiao Xu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Meta Analysis ◽  
Motor Impairment ◽  
Mean Difference ◽  
China National Knowledge Infrastructure ◽  
Knowledge Infrastructure ◽  
Effective Option ◽  
Telehealth Intervention

Introduction Telehealth intervention has been proposed as a sustainable and innovative intervention approach to Parkinson’s disease (PD) patients, but there are still conflicting results in the literature about its effect. This study aimed to evaluate the efficacy of telehealth intervention for PD patients. Methods PubMed, EMBASE, CENTRAL and China National Knowledge Infrastructure (CNKI) were searched from the inception to June 2018 for randomized controlled trials (RCTs) and cohort studies, without language restrictions. When feasible, data were statistically pooled for meta-analysis using Review Manager 5.3. Otherwise, narrative summaries were used. Results Twenty-one studies were included. With respect to PD severity, compared with usual care, telehealth intervention was beneficial in lowering motor impairment of PD patients significantly (mean difference (MD) = –2.27, 95% confidence interval (95% CI) −4.25 to −0.29, p = 0.02), rather than mental status (MD = –0.98, 95% CI −2.61 to 0.65, p = 0.24), activities of daily living (MD = –1.51, 95% CI −4.91 to 1.89, p = 0.38) and motor complications (MD = –0.36, 95% CI −1.31 to 0.59, p = 0.46). Telehealth intervention did not lead to significant reduction in quality of life (standardized mean difference (SMD) = 0.04, 95% CI −0.20 to 0.28, p = 0.76), depression (SMD = –0.12, 95% CI −0.37 to 0.13, p = 0.34), cognition (MD = 0.37, 95% CI −0.34 to 1.09, p = 0.31) and balance (MD = 0.09, 95% CI −2.49 to 2.66, p = 0.95). Discussion Telehealth intervention is an effective option for individuals with PD to improve their motor impairment. Further well-designed studies are warranted to confirm our findings.

scholarly journals Progression of Voice and Speech Impairment in the Course of Parkinson's Disease: A Longitudinal Study

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
S. Skodda ◽  
W. Grönheit ◽  
N. Mancinelli ◽  
U. Schlegel
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Acoustic Analysis ◽  
Motor Impairment ◽  
Time Interval ◽  
Speech Impairment ◽  
Speech Performance ◽  
The Individual ◽  
Voice And Speech

Impairment of voice and speech occurs in the majority of patients in the course of Parkinson's disease (PD). The aim of the current study was to survey the changes of voice and speech performance in the individual patients over time. 80 patients with PD and 60 healthy speakers were tested and retested after at least 12 months (average time interval: 32.5 months). Participants had to read a given text which was digitally recorded as a source for the perceptual and acoustic analysis. Stage of the disease and global motor impairment were rated according to the accepted scales. As a result, abnormalities of voice and speech were already present in mildly affected patients and there were significant deteriorations of quality of voice and articulatory velocity and precision between baseline and followup examination which showed no correlation with the time interval between the visits. Summarized, voice, and speech performance were found to further deteriorate in the individual patient in the course of time although global motor impairment was widely stable which might be a hint for nondopaminergic mechanisms of progression of dysarthrophonia. Further investigations are warranted to get a better insight into the dynamics of the progression of voice and speech impairment in PD as a precondition for the development of therapeutic approaches.

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