ABSTRACT Objective: to investigate the literature production on the design of forms for research in the health area and describe the most relevant concepts and precepts of the topic. Methods: an integrative literature review in the PubMed and Scielo databases with the key words: survey, constructing, questionnaire, formulary, development and design in various combinations, including articles published in any language in the last ten years. The survey returned 1,480 articles, and after reading and critically reviewing the abstracts according to the objective of the study, 16 articles were selected for complete reading. Information regarding aspects that were most relevant to the objective of the study was analyzed, as well as its recurrence in the selected articles. Results: the reading of the 16 articles resulted in three categories, based on the recurrence of the themes: structure, validation and sampling. Conclusion: clarity in the formulation of the questions was the most valued aspect in the structure of the instrument. As for validation, the realization of pilot tests was considered fundamental. Finally, the method of administration and adaptation of the questionnaire to target population was considered fundamental.
The difference electron-density map as a crystal structure validation tool
