The conceptualization of dynamic resource orchestration framework as an anchor for organizational resilience

The objective of this paper was to present a dynamic resource orchestration framework as a source of organizational resilience through blended orchestration of the firm's dynamic and static resources to generate sustained value during disruptive shocks. We adopted an integrative literature review methodology and proposed a dynamic resource orchestration framework as a managerial option to create and sustain firm value. Conceptually, a dynamic resource orchestration framework was presented as the integration of firm resources and managerial capability. We proposed dynamic resource orchestration as a model input impacting organizational resilience through the combined effects of resource accumulation, resource orchestration, and managerial capabilities. Through a thorough examination of the literature production anchored on dynamic capabilities framework and organizational resilience, we advanced a perspective that the ultimate source of combined firm resilience and sustainable competitive advantage does not necessarily accrue from the resources at a firm's disposal but by how management dynamically blends and orchestrates the existing resources, thereby creating an optimal source of capability. Our proposed conceptualization was based on the assumption that dynamic capabilities are part of firm resources and, therefore, strategic orchestration of dynamic capabilities leads to superior firm resourcefulness and consequential sustained resilience. We identified gaps and proposed directions for future research.

Electrosprayed Nanoparticles as Drug Delivery systems for Biomedical Applications

Background: Nanotechnology is a tool being used intensely in the area of drug delivery systems in the biomedical field. Electrospraying is one of the nanotechnological methods, which is growing due to its importance in the development of nanoparticles comprising bioactive compounds. It is helpful in improving the efficacy, reducing side effects of active drug elements, and is useful in targeted drug delivery. When compared to other conventional methods like nanoprecipitation, emulsion diffusion, and double emulsification, electrospraying offers better advantages to produce micro/nanoparticles due to its simplicity, cost-effectiveness, and single-step process. Objective: The aim of this paper is to highlight the use of electrosprayed nanoparticles for biomedical applications. Methods: We conducted a literature review on the usage of natural and synthetic materials to produce nanoparticles, which can be used as a drug delivery system for medical purposes. Results: We summarized a possible key role of electrosprayed nanoparticles in different therapeutic applications (tissue regeneration, cancer). Conclusion: The modest literature production denotes that further investigation is needed to assess and validate the promising role of drug-loaded nanoparticles through the electrospraying process as noninvasive materials in the biomedical field.

Life on Mars (LoMars): A bibliometric study of current research and future perspectives

A quest for life on Mars (LoMars) started in the early 1960s when several research articles were published by the most prestigious scientific journals. The rise in annual literature production started in the late 1990s, most likely associated with the launch of the National Aeronautics and Space Administration’s (NASA) first Sojourner Rover in 1996. This trend predicts that the articles on Mars would further increase in the future given the fact that the recent launch and landing of the Mars 2020 Perseverance Rover is of utmost importance to find and understand the present or past life on the planet. So far, USA dominated the citations and collaborations with the rest of the world on Mars research given its facilities equipped with relevant infrastructure and researchers’ capacity to explore the Solar System beyond Earth. Majority of these frequently cited papers report results of observational and theoretical research; however, the highly cited paper (MCKAY D. S. et al. 1996) is based on analytical studies of a unique Martian meteorite (i.e., Allan Hills 84001) found in the Antarctica. It is expected that the sample return mission associated with the Perseverance Rover could possibly increase the LoMars research exponentially in the coming decades if Martian samples are successfully brought back to Earth. Based on the total number of publications on LoMars, highly influential institute, author, and journal represent Caltech, McKay C. P., and Icarus, respectively. Both the institute and the author are directly affiliated with the NASA, suggestive of the leadership offered by the organization in LoMars research.

Romani literature and its digital forms

Since the late 1990s and particularly after 2000, Romani literature has been characterized in part by the influence of international and global developments within the Romani movement as well as the growth of digital technologies and the internet. Romani publications are going digital in different formats, including the digitization of public domain materials, e-books, audiobooks, internet publishing and social media publishing. This article discusses how digital technologies have been incorporated in Romani literature production and proposes a typology of the digital forms of Romani literature. It also provides an analysis of the issues and challenges that are observed in Romani digital publishing, some of which are specifically related to this type of publishing, while others apply to Romani literature in general.

Focus on MicroRNAs as Biomarker in Pediatric Diseases

Background: MiRNAs are a class of small non-coding RNAs that are involved in the post-transcriptional regulation of gene expression. MiRNAs are considered a class of epigenetic biomarkers. These biomarkers can investigate a disease at different stages: diagnosis, therapy or clinical follow up. Objective: The aim of this paper is to highlight the innovative use of miRNAs in several children diseases. Methods: We conducted a literature review to search the usage of miRNAs in pediatric clinical routine or experimental trials. Results: We found a possible key role of miRNAs in different pediatric illness (metabolic alterations, coagulation defects, cancer). Conclusion: The modest literature production denote that further investigation are needed to assess and validate the promising role of miRNAs as non-invasive biomarkers in pediatric disorders.

The Dubious Battle of Reichshoffen

Newspapers’ disregard for fact created fertile ground for the growth of national myth. A perhaps fictitious Parisian news report on the Battle of Reichshoffen, which took place just before the siege on the Franco-Prussian border, became one such myth. A few conflicting accounts of this early battle in the war turned into a play, a poem, and a panorama, and perhaps later led to the successful campaign of Patrice de Mac Mahon for President of the French Republic. But it is impossible to verify whether the Battle was a French victory or a defeat. This ambiguity was inherent to newspaper poetics during the siege, and while frustrating for any reader looking for truth, it shows how profitable and how ideologically productive ambiguity could be. Much like the Battle of Waterloo, the Battle of Reischshoffen grew to become a national-historical allegory due to the particularities of literature production in times of war.

THU0469 QUANTIFYING THE PLACEBO EFFECT AFTER INTRA-ARTICULAR INJECTIONS: IMPLICATIONS FOR TRIALS AND PRACTICE

Background:In recent years, diverse compounds for intra-articular administration were brought into the market with a subsequent significant and heterogeneous literature production. Understanding the efficacy of intra-articular therapies (IAT) on pain implies bearing in mind the related placebo (PBO) effect. To date, most studies analyzing it were focused on the compound being administered rather than the route of administration.Objectives:We aimed at evaluating the size of the PBO effect after intra-articular injections.Methods:We conducted an overview of systematic reviews (SRs) including randomized-controlled trials (RCTs) of frequently used IAT. SRs with a saline solution PBO arm and high-confidence results according to the AMSTAR-2 tool were selected for analysis.Data on the change in pain in the PBO arms from baseline to 3-6 and 12-16 weeks after the IA procedure was extracted. The standardized mean differences (SMD) from baseline were calculated as the ratio between the size of the intervention effect in each study and the variability observed in that study. A meta-analysis was then performed using an inverse-variance random-effects model in Review Manager 5.3. The overall effect sizes obtained refer to versions of the SMD, which corresponds to the Hedges’ (adjusted) g. e.g. a “g” of 1 indicates the two groups being compared differ by 1 standard deviation and so on.Results:Two SR were included comprising 50 RCTs, 44 not meeting inclusion criteria were excluded so pain, measured by visual analogue scale (VAS) and Lequesne index, was retrieved from 6 RCT.At 3-6 weeks, an SMD [95%CI] = 0.74 [0.47-1.00] was found. One study showing too large an effect was excluded after conducting sensitivity analysis resulting in a significant reduction of heterogeneity with an SMD = 0.62 [0.45-0.79] (Fig.1). At 12-16 weeks, we found a SMD = 0.33 [0.13-0.52] (Fig.2)Figure 1.Forest plot for intra-articular PBO effect at 3-6 weeks after injection.Figure 2.Forest plot for intra-articular PBO effect at 12-16 weeks after injection.Using the interpretation suggested by Cohen1, our results would confirm a moderate to large effect of IA saline (PBO) at 3-6 weeks with a subsequent reduction to a small but persistent effect at 12-16 weeks.Conclusion:Our results showed a moderate to large short-term effect of intra-articular PBO that persisted on the mid-term although reduced. Based on these findings we suggest this effect should be considered when assessing the efficacy of IAT in RCTs and also in clinical practice where it could be maximized as well.References:[1]Cohen J. Statistical Power Analysis in the Behavioural Sciences (2nd edition). Hillsdale (NJ): Lawrence Erlbaum Associates, Inc., 1988.Disclosure of Interests: :Sebastian C Rodriguez-García Speakers bureau: Novartis Farmaceutica, S.A., Merck Sharp & Dohme España, S.A., Sanofi Aventis, UCB Pharma, Raul Castellanos-Moreira Speakers bureau: Lilly, MSD, Sanofi, UCB, Jacqueline Uson Jaeger: None declared, Esperanza Naredo: None declared, Loreto Carmona Grant/research support from: Novartis Farmaceutica, SA, Pfizer, S.L.U., Merck Sharp & Dohme España, S.A., Roche Farma, S.A, Sanofi Aventis, AbbVie Spain, S.L.U., and Laboratorios Gebro Pharma, SA (All trhough institution)