Probing the free-state solution behavior of drugs and their tendencies to self-aggregate into nano-entities

2021 ◽  
Author(s):  
Steven R. LaPlante ◽  
Valérie Roux ◽  
Fatma Shahout ◽  
Gabriela LaPlante ◽  
Simon Woo ◽  
...  
Author(s):  
O. T. Minick ◽  
M. C. Kew

The effects of heat stroke on hepatic structure were studied in 32 Bantu patients who worked underground in the Transvaal and Orange Free State Gold Mines.Judging from biochemical and morphologic findings, liver damage is an invariable complication of heat stroke. In the milder cases (90 per cent) raised enzyme levels, bromsulphalein retention, and increased prothrombin times were the most common abnormalities.


2020 ◽  
Vol 44 (15) ◽  
pp. 5762-5773 ◽  
Author(s):  
Tatiyana V. Serebryanskaya ◽  
Mikhail A. Kinzhalov ◽  
Vladimir Bakulev ◽  
Georgii Alekseev ◽  
Anastasiya Andreeva ◽  
...  

Water soluble Pd(ii) and Pt(ii)–ADC species synthesized via the metal-mediated coupling of isocyanides and 1,2-diaminobenzene have demonstrated antitumor potential.


2019 ◽  
Vol 27 (2) ◽  
Author(s):  
Willem Boshoff

Journal for Semitics 27 (1) 2018, #3010https://doi.org/10.25159/1013-8471/3010           When this article was originally published, Robert D. Holmstedt’s affiliation with the University of the Free State was accidentally omitted. The electronic version of the article has been corrected and can be located under the DOI specified above.


2019 ◽  
Vol 48 (1) ◽  
Author(s):  
David Matheakuena Mohale

The 2016–17 Audit Report by the Auditor General points to the deterioration in audit results of South African municipalities. This deterioration confirms the perennial dysfunctionality of municipalities, at least from the governance perspective. Corporate governance is a function of leadership. Municipal councils are, therefore, responsible for the overall performance of municipalities they lead. Sound regulatory framework, good plans, clear strategies, policies, and systems are inadequate if not supported by highly gifted and ethical leadership. The Auditor General’s Audit Report suggests that local government struggles the most in the area of ethics. The Principal-Agent Theory argues that appointed officials are more likely to subvert the interests of an organisation. However, this article argues that the primary source of problems in municipalities is a combination of ineptitude and unethical political leadership taking root. This conclusion is based on the empirical comparative cases of eight municipalities in the Free State Province.  The conduct of councillors makes it difficult to attract and retain professionals in municipalities, resulting in notable deficiencies in the delivery of services. Essentially, councillors are the root cause for governance failure in municipalities arising from a number of factors. Findings in this study contribute towards the understanding of the impact of leadership in the failure of municipalities to meet good governance and developmental objectives. Further, they deepen the theoretical understanding of the political-administrative interface.


2020 ◽  
Author(s):  
Anna Kataki-Anastasakou ◽  
Jonathan C. Axtell ◽  
Selena Hernandez ◽  
RafalM. Dziedzic ◽  
Gary J. Balaich ◽  
...  

High affinity guest have been reported for the macrocyclic host cucurbit[7]uril (CB[7]), enabling widespread applications, but preventing CB[7] materials from being returned to their guest-free state for reuse. Here we present polyhedral boron clusters (carboranes) as strongly-binding, yet easily removable, guests for CB[7]. Aided by a Pd-catalyzed coupling of an azide anion, we prepared boron-functionalized 9<i>-</i>amino and 9-ammonium modified <i>ortho-</i>carboranes that bind to CB[7] with a <i>K<sub>a</sub></i>=10<sup>10</sup> M<sup>-1</sup>. Upon treatment with base, the <i>ortho</i>-carboranes<i> </i>readily undergo deboronation to yield anionic <i>nido</i>-carborane, a poor guest of CB[7], facilitating recovery of guest-free CB[7]. We showcase the utility of the modified <i>ortho</i>-carborane guest by recycling a CB[7]-functionalized resin. With this report, we introduce stimuli-responsive decomplexation as an additional consideration in the design of high affinity host-guest complexes.


2009 ◽  
Vol 14 (2) ◽  
pp. 120-133 ◽  
Author(s):  
As'ad Ghanem

2019 ◽  
Vol 94 (2) ◽  
pp. 35-44 ◽  
Author(s):  
G. Toleutay ◽  
◽  
A.V. Shakhvorostov ◽  
S.K. Kabdrakhmanova ◽  
S.E. Kudaibergenov ◽  
...  

2020 ◽  
Vol 46 (3) ◽  
pp. 101-121
Author(s):  
Matthew G. Stanard

Studies of the visual culture of the Congo Free State (CFS) have focused overwhelmingly yet narrowly on the “atrocity” photograph used to criticize Leopold II’s colonial misrule. This article presents a new picture of the visual culture of Leopold II’s Congo Free State by examining a broader, more heterogeneous range of fin de siècle images of varied provenance that comprised the visual culture of the CFS. These include architecture, paintings, African artwork, and public monuments, many of which were positive, pro-Leopoldian images emphasizing a favorable view of colonialism. The visual culture of the CFS was imbued with recurring themes of violence, European heroism, and anti-Arab sentiment, and emerged from a unique, transnational, back-and-forth process whereby Leopold and his critics instrumentalized images to counter each other and achieve their goals.


Sign in / Sign up

Export Citation Format

Share Document