scholarly journals Contribution of multidrug and toxin extrusion protein 1 (MATE1) to renal secretion of trimethylamine-N-oxide (TMAO)

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
A. Gessner ◽  
J. König ◽  
M. F. Fromm
Keyword(s):  
Renal Secretion ◽  
Toxin Extrusion

scholarly journals Atenolol Renal Secretion Is Mediated by Human Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Proteins

2015 ◽  
Vol 43 (12) ◽  
pp. 1872-1881 ◽  
Author(s):  
Jia Yin ◽  
Haichuan Duan ◽  
Yoshiyuki Shirasaka ◽  
Bhagwat Prasad ◽  
Joanne Wang
Keyword(s):  
Organic Cation ◽  
Organic Cation Transporter ◽  
Renal Secretion ◽  
Organic Cation Transporter 2 ◽  
Toxin Extrusion

Targeted Disruption of the Multidrug and Toxin Extrusion 1 (Mate1) Gene in Mice Reduces Renal Secretion of Metformin

2009 ◽  
Vol 75 (6) ◽  
pp. 1280-1286 ◽  
Author(s):  
Masahiro Tsuda ◽  
Tomohiro Terada ◽  
Tomoyuki Mizuno ◽  
Toshiya Katsura ◽  
Jin Shimakura ◽  
...  
Keyword(s):  
Renal Secretion ◽  
Targeted Disruption ◽  
Toxin Extrusion

scholarly journals The role of glutathione turnover in the apparent renal secretion of cystine.

1981 ◽  
Vol 256 (23) ◽  
pp. 12263-12268 ◽  
Author(s):  
O.W. Griffith
Keyword(s):  
Renal Secretion

Principles of Alternating Access in Multidrug and Toxin Extrusion (MATE) Transporters

2021 ◽  
pp. 166959
Author(s):  
Derek P. Claxton ◽  
Kevin L. Jagessar ◽  
Hassane S. Mchaourab
Keyword(s):  
Alternating Access ◽  
Toxin Extrusion

scholarly journals Untargeted analysis of first trimester serum to reveal biomarkers of pregnancy complications: a case–control discovery phase study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
E. W. Harville ◽  
Y.-Y. Li ◽  
K. Pan ◽  
S. McRitchie ◽  
W. Pathmasiri ◽  
...  
Keyword(s):  
Pregnancy Complications ◽  
Predictive Power ◽  
Gestational Hypertension ◽  
Predictive Biomarkers ◽  
First Trimester ◽  
Resonance Spectroscopy ◽  
Renal Secretion ◽  
Global Alliance ◽  
Phase Study ◽  
High Resolution Mass Spectroscopy

AbstractUnderstanding of causal biology and predictive biomarkers are lacking for hypertensive disorders of pregnancy (HDP) and preterm birth (PTB). First-trimester serum specimens from 51 cases of HDP, including 18 cases of pre-eclampsia (PE) and 33 cases of gestational hypertension (GH); 53 cases of PTB; and 109 controls were obtained from the Global Alliance to Prevent Prematurity and Stillbirth repository. Metabotyping was conducted using liquid chromatography high resolution mass spectroscopy and nuclear magnetic resonance spectroscopy. Multivariable logistic regression was used to identify signals that differed between groups after controlling for confounders. Signals important to predicting HDP and PTB were matched to an in-house physical standards library and public databases. Pathway analysis was conducted using GeneGo MetaCore. Over 400 signals for endogenous and exogenous metabolites that differentiated cases and controls were identified or annotated, and models that included these signals produced substantial improvements in predictive power beyond models that only included known risk factors. Perturbations of the aminoacyl-tRNA biosynthesis, l-threonine, and renal secretion of organic electrolytes pathways were associated with both HDP and PTB, while pathways related to cholesterol transport and metabolism were associated with HDP. This untargeted metabolomics analysis identified signals and common pathways associated with pregnancy complications.

Tamsulosin Alters the Pharmacokinetics of Metformin Via Inhibition of Renal Multidrug and Toxin Extrusion Protein 1 and Organic Cation Transporter 2 in Rats

2021 ◽  
Author(s):  
Abdulaziz Ahmed A.Saad ◽  
Fan zhang ◽  
Moath Refata ◽  
Eyad Abdulwhab H.Mohammed ◽  
Mingkang Zhang ◽  
...  
Keyword(s):  
Organic Cation ◽  
Organic Cation Transporter ◽  
Organic Cation Transporter 2 ◽  
Toxin Extrusion

scholarly journals Interaction of environmental contaminants with zebrafish (Danio rerio) multidrug and toxin extrusion protein 7 (Mate7/Slc47a7)

2018 ◽  
Vol 205 ◽  
pp. 193-203 ◽  
Author(s):  
Jovica Lončar ◽  
Tvrtko Smital
Keyword(s):  
Danio Rerio ◽  
Environmental Contaminants ◽  
Toxin Extrusion

Organic cation transporter and multidrug and toxin extrusion 1 co-mediated interaction between metformin and berberine

2019 ◽  
Vol 127 ◽  
pp. 282-290 ◽  
Author(s):  
Rong Shi ◽  
Zhangyao Xu ◽  
Xining Xu ◽  
Jingyi Jin ◽  
Yining Zhao ◽  
...  
Keyword(s):  
Organic Cation ◽  
Organic Cation Transporter ◽  
Toxin Extrusion

Adaptive responses of renal organic anion transporter 3 (OAT3) during cholestasis

2008 ◽  
Vol 295 (1) ◽  
pp. F247-F252 ◽  
Author(s):  
Jiarong Chen ◽  
Tomohiro Terada ◽  
Ken Ogasawara ◽  
Toshiya Katsura ◽  
Ken-ichi Inui
Keyword(s):  
Bile Acids ◽  
Cholic Acid ◽  
Molecular Mechanisms ◽  
Competitive Inhibition ◽  
Organic Anion ◽  
Organic Anion Transporter ◽  
Specific Substrate ◽  
Renal Secretion ◽  
Sd Rats ◽  
Anion Transporter

During cholestasis, bile acids are mainly excreted into the urine, but adaptive renal responses to cholestasis, especially molecular mechanisms for renal secretion of bile acids, have not been well understood. Organic anion transporters (OAT1 and OAT3) are responsible for membrane transport of anionic compounds at the renal basolateral membranes. In the present study, we investigated the pathophysiological roles of OAT1 and OAT3 in terms of renal handling of bile acids. The Eisai hyperbilirubinemic rats (EHBR), mutant rats without multidrug resistance-associated protein 2, showed higher serum and urinary concentrations of bile acids, compared with Sprague-Dawley (SD) rats (wild type). The protein expression level of rat OAT3 was significantly increased in EHBR compared with SD rats, whereas the expression of rat OAT1 was unchanged. The transport activities of rat and human OAT3, but not OAT1, were markedly inhibited by various bile acids such as chenodeoxycholic acid and cholic acid. Cholic acid, glycocholic acid, and taurocholic acid, which mainly increased during cholestasis, are transported by OAT3. The plasma concentration of β-lactam antibiotic cefotiam, a specific substrate for OAT3, was more increased in EHBR than in SD rats despite upregulation of OAT3 protein. This may be due to the competitive inhibition of cefotiam transport by bile acids via OAT3. In conclusion, the present study clearly demonstrated that OAT3 is responsible for renal secretion of bile acids during cholestasis and that the pharmacokinetic profile of OAT3 substrates may be affected by cholestasis.

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