scholarly journals Short and Long-Term Potential Role of Carbon Nanoparticles in Total Thyroidectomy with Central Lymph Node Dissection

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Shuai Xue ◽  
Peiyou Ren ◽  
Peisong Wang ◽  
Guang Chen
Keyword(s):  
Lymph Node ◽  
Carbon Nanoparticles ◽  
Potential Role ◽  
Node Dissection ◽  
Central Lymph Node ◽  
Central Lymph Node Dissection ◽  
Short And Long Term ◽  
Central Lymph

scholarly journals Prophylactic Bilateral Central Neck Dissection Should Be Evaluated Based on Prospective Study of 581 PTC Patients

2021 ◽  
Author(s):  
Shouyi YAN ◽  
Jiafan Yu ◽  
wenxin zhao ◽  
Bo WANG ◽  
Liyong ZHANG
Keyword(s):  
Lymph Node ◽  
Lymph Node Dissection ◽  
Test Group ◽  
Control Group ◽  
Node Dissection ◽  
Central Lymph Node ◽  
Central Lymph Node Dissection ◽  
Node Metastasis ◽  
Central Lymph

Abstract Background: Prophylactic central lymph node dissection (PCND) had been a basic consensus for patients with papillary thyroid carcinoma in China. However, unilateral or bilateral central lymph node dissection (CND)was still controversial. This study aimed at investigating the safety and long-term benefit for the patients with bilateral central lymph node dissection (BCCD). Methods: 581 patients were enrolled and divided randomly into the test and control groups according to a different range of CND. 285 patients were prospectively assigned to undergo lobe thyroidectomy plus BCND in the test group, in comparison 296 patients were assigned to undergo lobe thyroidectomy plus ipsilateral central lymph node dissection (ICND) in the control group. Results: We found that the numbers of total LN and N1a in the test group were higher than that of the control group (p=0.002), but there was no difference in the number of metastasized lymph nodes (p=0.857) and tumor recurrence (p=0.308). Additionally, in the aspect of postoperative complication (1 day after surgery), the serum levels of parathyroid hormone in the BCND group were lower than that in the ICND group (P =0.010), and the numbers of transient laryngeal nerve palsy were higher than that(p=0.033). meanwhile we further found that tumors size larger than 1cm and tumor side lymph node metastasis were related to the contralateral lymph node metastasis. Conclusion: BCND resulted in more positive lymph nodes and complications while did not change the patient's long-term prognosis. It may be an alternative for patients with tumor sizes larger than 1cm in large medical centers.

scholarly journals Prophylactic Bilateral Central Neck Dissection Should Be Carefully Evaluated Based on Prospective Study of 581 Cases With cN0 Papillary Thyroid Carcinoma

2021 ◽  
Author(s):  
Shouyi Yan ◽  
Wen Xin Zhao ◽  
Bo Wang ◽  
Liyong Zhang
Keyword(s):  
Lymph Node ◽  
Lymph Node Dissection ◽  
Test Group ◽  
Control Group ◽  
Node Dissection ◽  
Central Lymph Node ◽  
Central Lymph Node Dissection ◽  
Node Metastasis ◽  
Central Lymph

Abstract Background: prophylactic central lymph node dissection (PCND) had been a basic consensus for patients with papillary thyroid carcinoma (PTC) in China. However, unilateral or bilateral central lymph node dissection (CND)was still controversial. This study aimed at investigating the safety and long-term benefit for the patients with bilateral central lymph node dissection (BCCD). Methods: 581 patients were enrolled and divided randomly into the test and control groups according to a different range of CND. 285 patients were prospectively assigned to undergo lobe thyroidectomy plus BCND in the test group, in comparison 296 patients were assigned to undergo lobe thyroidectomy plus ipsilateral central lymph node dissection (ICND) in the control group. Results: We found that the numbers of total LN and N1a in the test group were higher than that of the control group (p = 0.002), but there was no difference in the number of metastasized lymph nodes (p = 0.857) and tumor recurrence (p = 0.308). Additionally, in the aspect of postoperative complication (1 day after surgery), the serum levels of parathyroid hormone in the BCND group were lower than that in the ICND group (P = 0.010), and the numbers of transient laryngeal nerve palsy were higher than that(p = 0.033). meanwhile we further found that tumors size larger than 1cm and tumor side lymph node metastasis were related to the contralateral lymph node metastasis. Conclusion: BCND resulted in more positive lymph nodes and similar surgical complications compared with ICND but did not change the patient's long-term prognosis. It may be an alternative for patients with tumor sizes larger than 1cm. Meanwhile, and it should be done in large medical centers, with rich experience in PG and RLN protection

The long term outcome of papillary thyroid carcinoma patients without primary central lymph node dissection: Expected improvement of routine dissection

Surgery ◽  
2009 ◽  
Vol 146 (6) ◽  
pp. 1188-1195 ◽  
Author(s):  
Yasemin Giles (Senyurek) ◽  
Fatih Tunca ◽  
Harika Boztepe ◽  
Faruk Alagöl ◽  
Tarık Terzioglu ◽  
...  
Keyword(s):  
Lymph Node ◽  
Expected Improvement ◽  
Papillary Thyroid ◽  
Node Dissection ◽  
Central Lymph Node ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Central Lymph Node Dissection ◽  
Central Lymph

scholarly journals Select group of patients might benefit from prophylactic central lymph node dissection in clinically node negative papillary thyroid microcarcinoma

2020 ◽  
Author(s):  
Jungbin Kim ◽  
Hyunjin Cho ◽  
Geumhee Gwak ◽  
Keunho Yang ◽  
Ye Young Seo ◽  
...  
Keyword(s):  
Lymph Node ◽  
Primary Tumor ◽  
Papillary Thyroid ◽  
Node Dissection ◽  
Central Lymph Node ◽  
Central Lymph Node Dissection ◽  
Node Metastasis ◽  
Thyroid Microcarcinoma ◽  
Pet Ct ◽  
Central Lymph

Objective: The aim of this study was to identify predictive factors for pathologic central lymph node metastasis (CLNM) in patients with clinically negative CLNM (cN0) papillary thyroid microcarcinoma (PTMC) to suggest a specific group of cN0 PTMC patients who has benefit from prophylactic central lymph node dissection (CLND). Background: PTMC have excellent prognosis, however, 8% have recurrent disease. Recurrence is associated with regional lymph node metastasis. It has been reported that pathologic CLNM is found in 30 to 65% of cN0 PTMC patients. However, prophylactic CLND for cN0 PTMC remains controversial. Methods: We reviewed the records of papillary thyroid carcinoma patients with a tumor size on preoperative ultrasonography (US) of ≤ 10 mm and negative CLNM on preoperative physical examination, US, and positron emission tomography/computed tomography (PET/CT), who underwent total thyroidectomy or thyroid lobectomy with prophylactic CLND between April 2010 and February 2013. In total, 163 patients were included. We evaluated the relationship between preoperatively assessable factors including age, gender, body mass index, preoperative metformin use, primary tumor size through preoperative US, the maximum standardized uptake value (SUVmax) of the primary tumor through preoperative PET/CT, and the bilaterality of the primary tumor and pathologic CLNM. Results: A SUVmax of the primary tumor of > 3 was an independent preoperatively assessable factor predictive of pathologic CLNM in cN0 PTMC patients. Conclusions: Prophylactic CLND might be considered in cN0 PTMC patients with a SUVmax of the primary tumor of > 3 to reduce the risks of residual CLNM and recurrence.

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