Lymphovascular invasion have a similar prognostic value as lymph node involvement in patients undergoing radical cystectomy with urothelial carcinoma

Abstract Background : To assess the prognostic value of preoperative serum cyfra21-1 in male patients with urothelial carcinoma of bladder treated with radical cystectomy.Methods: Patients underwent radical cystectomy from 2009-2018 at our center were retrospectively analyzed and 267 male patients met our criterions. The median follow-up was 34 months. The serum level of cyfra21-1 was measured using enzyme linked immunosorbent assay. Patients were divided into two groups (cyfra21-1≤3.30ng/ml and cyfra21-1>3.30 ng/ml). Clinical significance of cyfra21-1 level was assessed.Results: Of the 267 patients, 110 (41.2%) had normal cyfra21-1, while 157 (58.8%) had elevated serum cyfra21-1. The prevalence of lymph node involvement, locally advanced stage (≥ pT3), tumor stages, tumor size and papillary were significantly higher in patients with elevated cyfra21-1 than in those with normal cyfra21-1. Patients with high cyfra21-1 showed worse Disease free survival and Overall survival than those with low cyfra21-1 ( P = 0.001 and 0.007, respectively). In multivariate analysis, High cyfra21-1, lymph node involvement, lymphovascular invasion and papillary were independent predictors of worse Disease free survival ( P = 0.036, <0.001, 0.002, 0.014 respectively). High cyfra21-1, lymph node involvement and lymphovascular invasion were also confirmed as independent predictors of worse Overall survival ( P = 0.038, 0.010, 0.005, respectively.)Conclusions: Elevated cyfra21-1 was associated with greater biological aggressiveness and worse prognosis than normal cyfra21-1.

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Cancer-specific mortality following radical cystectomy for bladder cancer with lymph node involvement: impact of pathologic disease features and adjuvant chemotherapy

World Journal of Urology ◽

10.1007/s00345-014-1319-0 ◽

2014 ◽

Vol 33 (3) ◽

pp. 373-379 ◽

Cited By ~ 6

Author(s):

Marisa M. Clifton ◽

Sarah P. Psutka ◽

Stephen A. Boorjian ◽

John C. Cheville ◽

Prabin Thapa ◽

...

Keyword(s):

Bladder Cancer ◽

Lymph Node ◽

Adjuvant Chemotherapy ◽

Radical Cystectomy ◽

Lymph Node Involvement ◽

Specific Mortality ◽

Node Involvement ◽

Cancer Specific Mortality

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Lymph node involvement and lymphovascular invasion in deep infiltrating rectosigmoid endometriosis

Fertility and Sterility ◽

10.1016/j.fertnstert.2007.05.011 ◽

2008 ◽

Vol 89 (5) ◽

pp. 1069-1072 ◽

Cited By ~ 53

Author(s):

Jean-Christophe Noël ◽

Charles Chapron ◽

Isabelle Fayt ◽

Vincent Anaf

Keyword(s):

Lymph Node ◽

Lymphovascular Invasion ◽

Lymph Node Involvement ◽

Node Involvement

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Upper tract urothelial carcinoma with isolated lymph node involvement following surgical resection: Implications for multi-modal management.

Journal of Clinical Oncology ◽

10.1200/jco.2018.36.15_suppl.e16594 ◽

2018 ◽

Vol 36 (15_suppl) ◽

pp. e16594-e16594

Author(s):

Aryeh Pelcovits ◽

Anthony E. Mega ◽

Dragan Golijanin ◽

Ali Amin ◽

Boris Gershman

Keyword(s):

Lymph Node ◽

Urothelial Carcinoma ◽

Surgical Resection ◽

Lymph Node Involvement ◽

Upper Tract Urothelial Carcinoma ◽

Upper Tract ◽

Node Involvement

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Detection of Lymphovascular Invasion by D2-40 (Podoplanin) Immunoexpression in Endometrial Cancer

International Journal of Gynecological Cancer ◽

10.1097/igc.0b013e318269139b ◽

2012 ◽

Vol 22 (8) ◽

pp. 1442-1448 ◽

Cited By ~ 25

Author(s):

Sarah K. Weber ◽

Axel Sauerwald ◽

Martin Pölcher ◽

Michael Braun ◽

Manuel Debald ◽

...

Keyword(s):

Overall Survival ◽

Endometrial Cancer ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Lymphovascular Invasion ◽

Lymph Node Involvement ◽

Lymph Vessel ◽

Node Metastasis ◽

Lymph Vessel Invasion ◽

Node Involvement

BackgroundLymph node involvement is a major feature in tumor spread of endometrial cancer and predicts prognosis. Therefore, evaluation of lymph vessel invasion (LVI) in tumor tissue as a predictor for lymph node metastasis is of great importance. Immunostaining of D2-40 (podoplanin), a specific marker for lymphatic endothelial cells, might be able to increase the detection rate of LVI compared with conventional hematoxylin-eosin (H-E) staining. The aim of this retrospective study was to analyze the eligibility of D2-40–based LVI evaluation for the prediction of lymph node metastases and patients’ outcome.Patients and MethodsImmunohistochemical staining with D2-40 monoclonal antibodies was performed on paraffin-embedded tissue sections of 182 patients with primary endometrioid adenocarcinoma treated in 1 gynecologic cancer center. Tumors were screened for the presence of LVI. Correlations with clinicopathological features and clinical outcome were assessed.ResultsImmunostaining of D2-40 significantly increased the frequency LVI detection compared with conventional H-E staining. Lymph vessel invasion was identified by D2-40 in 53 (29.1%) of 182 tumors compared with 34 (18.3%) of 182 carcinomas by routine H-E staining (P = 0.001). D2-40 LVI was detectable in 81.0% (17/21) of nodal-positive tumors and significantly predicted lymph node metastasis (P = 0.001). Furthermore, D2-40 LVI was an independent prognostic factor for patients overall survival considering tumor stage, lymph node involvement, and tumor differentiation (P < 0.01). D2-40–negative tumors confined to the inner half of the myometrium showed an excellent outcome (5-year overall survival, 97.8%).ConclusionsD2-40–based LVI assessment improves the histopathological detection of lymphovascular invasion in endometrial cancer. Furthermore, LVI is of prognostic value and predicts lymph node metastasis. D2-40 LVI detection might help to select endometrial cancer patients who will benefit from a lymphadenectomy.

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Extranodal Extension Predicts Poor Survival Outcomes among Patients with Bladder Cancer

Cancers ◽

10.3390/cancers13164108 ◽

2021 ◽

Vol 13 (16) ◽

pp. 4108

Author(s):

Yi-An Liao ◽

Chun-Ju Chiang ◽

Wen-Chung Lee ◽

Bo-Zhi Zhuang ◽

Chung-Hsin Chen ◽

...

Keyword(s):

Bladder Cancer ◽

Lymph Node ◽

Adjuvant Chemotherapy ◽

Cancer Patients ◽

Radical Cystectomy ◽

Lymph Node Involvement ◽

Survival Outcomes ◽

Nodal Disease ◽

Extranodal Extension ◽

Node Involvement

Background: Several lymph node-related prognosticators were reported in bladder cancer patients with lymph node involvement and receiving radical cystectomy. However, extranodal extension (ENE) remained a debate to predict outcomes. Methods: A retrospective analysis of 1303 bladder cancer patients receiving radical cystectomy and bilateral pelvic lymph node dissection were identified in the National Taiwan Cancer Registry database from 2011 to 2017. Based on the 304 patients with lymph node involvement, the presence of ENE and major clinical information were recorded and calculated. The overall survival (OS) and cancer-specific survival (CSS) were estimated with Kaplan–Meier analysis and compared using the log-rank test. Hazard ratios (HR) and the associated 95% confidence intervals were calculated in the univariate and stepwise multivariable models. Results: In the multivariable analysis, ENE significantly reduced OS (HR = 1.74, 95% CI 1.09–2.78) and CSS (HR = 1.69, 95% CI 1.01–2.83) more than non-ENE. In contrast, adjuvant chemotherapy was significantly associated with better OS and CSS upon the identification of pathological nodal disease. Conclusions: Reduced OS and CSS outcomes were observed in the pathological nodal bladder cancer patients with ENE compared with those without ENE. After the identification of pathological nodal disease, adjuvant chemotherapy was associated with better survival outcomes.

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