scholarly journals Sr/PTA Metal Organic Framework as A Drug Delivery System for Osteoarthritis Treatment

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Zhen Li ◽  
Ying Peng ◽  
Xingyu Xia ◽  
Zhe Cao ◽  
Yuqing Deng ◽  
...  

AbstractA Sr-based metal-organic framework (MOF) is introduced as ketoprofen carrier to form a comprehensive system for treating osteoarthritis (OA), and the drug loading amount and release rate is investigated. Structural characterization of the samples showed that Sr/PTA-MOF had good crystal morphology and structure, and chemical and thermal stability. Ketoprofen was successfully loaded on the MOF carrier, which had been identified by high performance liquid chromatography (HPLC) and thermogravimetric analysis (TGA). The release experiment manifested that more than 90% of ketoprofen released from Sr/PTA-MOF after 24 h, and ketoprofen delivery was mainly governed by the Higuchi model. Furthermore, cytotoxicity experiment manifested that synthesized MOF carrier had no poisonous effect on OA chondrocytes, which provided a preliminary foundation for the realization of comprehensive treating OA.

2021 ◽  
Author(s):  
Ning Liu ◽  
Qiaoqiao Zhang ◽  
Jingqi Guan

Seeking for low-cost and high-performance electrocatalysts for oxygen evolution reaction (OER) has drawn enormous research interest in the last few years. Reported herein is the topotactic construction of a binuclear...


2021 ◽  
Vol 371 ◽  
pp. 137826
Author(s):  
Xingyu Liu ◽  
Pingyuan Wang ◽  
Cuiping Chang ◽  
Yongmei Chen ◽  
Yanzhi Sun ◽  
...  

Nanoscale ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 6201-6211
Author(s):  
Wenxia Chen ◽  
Wei Wei ◽  
Kefeng Wang ◽  
Nan Zhang ◽  
Guangliang Chen ◽  
...  

A MOF-derived CoPO hollow polyhedron structure is designed by simultaneous oxidation/phosphatization processes during Ar–N2 RF plasma discharge.


Author(s):  
Davood Taherinia ◽  
Seyyed Heydar Moravvej ◽  
Mohammad Moazzeni ◽  
Elham Akbarzadeh

The development of efficient and cost-effective catalysts for the oxygen evolution reaction is highly desirable for applications that are based on sustainable and clean technologies. In this study, we report...


2021 ◽  
Vol 869 ◽  
pp. 159348
Author(s):  
Likang Fu ◽  
Wenqi Xiong ◽  
Qiming Liu ◽  
Shuyun Wan ◽  
Chenxia Kang ◽  
...  

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