scholarly journals Effect of simultaneous presence of anti-blood group A/B and -HLA antibodies on clinical outcomes in kidney transplantation across positive crossmatch: a nationwide cohort study

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Hyunwook Kwon ◽  
◽  
Jee Yeon Kim ◽  
Dong Hyun Kim ◽  
Youngmin Ko ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Graft Survival ◽  
Blood Group ◽  
Significant Risk ◽  
Hla Antibodies ◽  
Blood Group A ◽  
Abo Incompatibility ◽  
Group A ◽  
One Year ◽  
Positive Crossmatch

AbstractABO-incompatible (ABOi) and positive crossmatch (XM) kidney transplantation (KT) have been considered immunologically challenging. The present study analyzed the clinical outcomes in XM positive KT based on ABO incompatibility. We used data from the Korea Organ Transplantation Registry, a nationwide database, and a single-center registry. A total of 263 patients with positive XM were divided into an ABO compatible (ABOc) & XM positive (ABOc/XM+, n = 176) group and an ABOi & XM positive (ABOi/XM+, n = 87) group. The overall rejection rate one year after KT was significantly higher in the ABOi/XM+ group than in the ABOc/XM+ group (P < 0.01). A total of four mortalities occurred, all in the ABOi/XM+ patients (P < 0.01). There were no differences in surgical complications or the occurrence of infection-related complications, including BK virus nephropathy. Multivariate analysis indicated that female vs. male (odds ratio (OR), 2.27; P = 0.03), DSA class I (MFI/1000) (OR, 1.10; P = 0.03), DSA class II (MFI/1000) (OR, 1.10; P < 0.01), and ABOi & XM+ status (OR, 2.38; P < 0.01) were significant risk factors for acute rejection during the year after transplantation. Overall graft survival was inferior in ABOi/XM+ patients than in ABOc/XM+ patients (P = 0.02). ABO incompatibility in XM-positive KT patients was found to be a significant risk factor for the development of rejection within one year after transplantation as well as for long-term graft survival. The anti-blood group A, B and anti-HLA antibodies may show synergistic activity.

scholarly journals The Factors Influencing the Risk of Perforation in Patients with Peptic Ulcers: A Cross-Sectional Study from Central Iraq

2018 ◽  
Vol 35 (4) ◽  
pp. 282-288
Author(s):  
Ibtesam Khalid Salih ◽  
Ali Malik Sheya’a ◽  
Qays Ahmed Hassan ◽  
Ayad Khani Mykhan
Keyword(s):  
Risk Factors ◽  
Peptic Ulcer ◽  
Blood Group ◽  
Significant Risk ◽  
Minor Role ◽  
Peptic Ulcer Perforation ◽  
Peptic Ulcers ◽  
Female Ratio ◽  
Blood Group A ◽  
Group A

Abstract The aim of this study was to evaluate the risk factors that influence the perforation, regardless of the presence of H. pylori infection, in a sample of Iraqi patients with peptic ulcers, admitted to Al-Kindy Teaching Hospital. A total of 90 patients who had perforated peptic ulcer participated in this study. The diagnosis was based on history, clinical examination, laboratory and radiological investigations and was confirmed intraoperatively. A number of probable risk factors for perforation were investigated. Eighty participants were males and 10 were females (male to female ratio 8:1). About 42.2% of patients were in their fifth decade of life. Forty-nine (54.4%) patients were asymptomatic before perforation occurred. Among the risk factors, smoking (66.7%), stress (60%) and blood group A (53.3%) play a significant risk for the occurrence of perforation. We concluded that smoking, stress, non-steroidal anti-inflammatory drugs, and to a lesser extent fasting and blood group A, play a major role as risk factors for the occurrence of peptic ulcer perforation. Other factors seem to play a minor role in this respect.

scholarly journals Blood Group A Isoagglutinins in A2→ O Simultaneous Liver/Kidney Transplantation May Not Influence Kidney Function

2011 ◽  
Vol 11 (7) ◽  
pp. 1527-1530 ◽  
Author(s):  
C. F. Bryan ◽  
B. Abdulkarim ◽  
A. Nawabi ◽  
D. Stewart ◽  
S. G. Yarlagadda
Keyword(s):  
Kidney Transplantation ◽  
Kidney Function ◽  
Blood Group ◽  
Blood Group A ◽  
Group A

The Development of Severe Anti-HPA 1a-Related Neonatal Alloimmune Thrombocytopenia Is Influenced by the Maternal ABO Type.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 2093-2093 ◽  
Author(s):  
Maria T. Ahlen ◽  
Mette K. Killie ◽  
Anne Husebekk ◽  
Jens Kjeldsen-Kragh ◽  
Martin L. Olsson ◽  
...  
Keyword(s):  
Relative Risk ◽  
Blood Group ◽  
Intervention Program ◽  
Swedish Population ◽  
Allele Distribution ◽  
Blood Group A ◽  
Abo Incompatibility ◽  
Norwegian Population ◽  
Group A ◽  
Alloimmune Thrombocytopenia

Abstract About 100 000 pregnant women were included in a screening and intervention program aimed to reduce morbidity and mortality related to neonatal alloimmune thrombocytopenia (NAIT). NAIT due to HPA 1a immunization have many features in common with hemolytic disease of the newborn (HDN) caused by RhD immunization. Platelets express blood group A and B antigens, and as described in HDN, ABO incompatibility between mother and fetus could possibly protect against immunization against HPA 1a. The aim of the study was to describe the ABO distribution among the immunized mothers and examine whether ABO status of the mother influenced the severity of thrombocytopenia in the newborn. ABO typing of HPA 1a immunized women was routinely performed by serological methods during the screening. ABO genotyping resolving the major alleles (A1, A2, B, O1, O1v or O2 alleles) of the women and their newborns was performed by PCR-RFLP methods. The ABO distribution among the immunized HPA 1a negative women was found to be similar to the normal distribution in the Norwegian population, which may indicate that the ABO type does not influence the immunization mechanism. However, we find that HPA 1a immunized women of blood group A have a higher risk of delivering a child with severe NAIT (platelet count &lt; 50×109/L) than women with blood group O. Twenty percent of the immunized women with blood group O gave birth to children with severe NAIT, compared to 46% among the immunized blood group A mothers, resulting in a relative risk of 0.43 (95% CI 0.25–0.76). The ABO type of the newborn was not found to influence development of severe NAIT. The O1/O1v allele distribution among the immunized women with blood group O resembles the distribution reported for a Swedish population. However, only 2/22 (9.1%) pregnancies among the O1v negative blood group O mothers resulted in a newborn with severe NAIT, compared to 10/34 (29.4%) among the O1v-positive blood group O women, resulting in a relative risk of 0.31 (95% CI 0.07–1.28). The observation that the immune response against HPA 1a may have different consequences depending on the ABO blood group of the mother is interesting. O1v, also termed O02, constitutes a separate but ancient allelic lineage at the ABO locus and we are now in the process of examining if our observation is related to linkage disequilibrium between the ABO gene and one or more pregnancy-related immunoregulatory genes.

P157 Synergistic effect of anti-blood group A/B AND-HLA antibodies in kidney transplnatation

2019 ◽  
Vol 80 ◽  
pp. 179
Author(s):  
Hyunwook Kwon ◽  
Dong Hyun Kim ◽  
Youngmin Ko ◽  
Young Hoon Kim
Keyword(s):  
Synergistic Effect ◽  
Blood Group ◽  
Hla Antibodies ◽  
Blood Group A ◽  
Group A

scholarly journals Detection of allogeneic blood group A and B enzyme activities in patients with ABO incompatible kidney transplantation

Glycobiology ◽  
2010 ◽  
Vol 20 (10) ◽  
pp. 1251-1258 ◽  
Author(s):  
M. Tasaki ◽  
T. Nakajima ◽  
N. Imai ◽  
Y. Nakagawa ◽  
K. Saito ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Blood Group ◽  
Enzyme Activities ◽  
Allogeneic Blood ◽  
Blood Group A ◽  
Group A

scholarly journals Temporal Change in Blood Group after Bone Marrow Transplant: A Case of Successful ABO-Incompatible Deceased Donor Transplant

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Susanna Lam ◽  
Sebastian Hultin ◽  
John Preston ◽  
Scott Campbell
Keyword(s):  
Stem Cell ◽  
Kidney Transplantation ◽  
Blood Group ◽  
Stem Cell Transplant ◽  
Graft Function ◽  
Deceased Donor ◽  
Haematopoietic Stem Cell ◽  
Cell Transplant ◽  
Blood Group A ◽  
Group A

ABO-incompatible kidney transplantation has been successfully utilised in a deceased donor and living donor kidney transplantation to improve organ utilisation and decrease waiting times. We describe a case of a successful, unanticipated ABO-incompatible donation after cardiac death (DCD) kidney transplant in a patient who had a previous ABOi haematopoietic stem cell transplant (HSCT) and had reverted to his original blood group B, after matching as a blood group A recipient with a blood group A donor. The recipient was unsensitized with a cPRA which was 0% and no donor-specific antibodies and zero HLA mismatch. An urgent anti-A titre was 1 : 2. Given the low antibody titres, we proceeded to transplantation. The patient developed delayed graft function and required dialysis on postoperative day 1 and day 2. The creatinine fell spontaneously on day 5, with progressively increased urine output and stable graft function on discharge at day 6. Anti-A titres were 1 : 1 on serial postoperative measurements. There were no rejection episodes, and the patient has a functioning graft at 16 months posttransplant. We describe a rare case in which the blood group can change after stem cell transplant and should be checked. We also demonstrate that a DCD ABOi transplant in the context of low anti-A titres for a patient with previous ABOi stem cell transplant can be performed successfully with standard immunosuppression.

RELEVANCE OF CONTINUOUS DETECTION OF ALLOGENEIC BLOOD GROUP A AND B ENZYMES TO SUCCESSFUL ABO INCOMPATIBLE KIDNEY TRANSPLANTATION

2010 ◽  
Vol 90 ◽  
pp. 936
Author(s):  
M. Tasaki ◽  
S. Yazawa ◽  
T. Nakajima ◽  
N. Imai ◽  
Y. Nakagawa ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Blood Group ◽  
Allogeneic Blood ◽  
Blood Group A ◽  
Group A

scholarly journals ABO compatibility and platelet transfusions of alloimmunized thrombocytopenic patients

Blood ◽  
1979 ◽  
Vol 54 (3) ◽  
pp. 595-599 ◽  
Author(s):  
RJ Duguesnoy ◽  
AJ Anderson ◽  
PA Tomasulo ◽  
RH Aster
Keyword(s):  
Blood Group ◽  
Hla Antigens ◽  
Platelet Recovery ◽  
Blood Group A ◽  
Abo Incompatibility ◽  
Group A ◽  
The Mean ◽  
Platelet Transfusions

Abstract With data on 91 alloimmunized thrombocytopenic patients and 389 donor- recipient pairs matched or selectively mismatched for HLA antigens, it was observed that ABO incompatibility significantly reduced the effectiveness of platelet transfusions. The mean 24-hr recovery of platelets from histocompatible donors and from donors selectively mismatched for cross-reactive HLA antigens was decreased by approximately 23% if the donor typed for blood group A and/or B not found in the recipient. Thus, the reduction in platelet recovery associated with ABO incompatibility is not of a magnitude that would contraindicate transfusion of ABO-mismatched platelets.

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