scholarly journals Multichannel anodal tDCS over the left dorsolateral prefrontal cortex in a paediatric population

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maike Splittgerber ◽  
Christoph Borzikowsky ◽  
Ricardo Salvador ◽  
Oula Puonti ◽  
Kiriaki Papadimitriou ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Task Performance ◽  
Dorsolateral Prefrontal Cortex ◽  
Flanker Task ◽  
Paediatric Population ◽  
Concurrent Task ◽  
Anodal Tdcs ◽  
Dorsolateral Prefrontal ◽  
Neurophysiological Activity ◽  
Back Task

AbstractMethodological studies investigating transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex (lDLPFC) in paediatric populations are limited. Therefore, we investigated in a paediatric population whether stimulation success of multichannel tDCS over the lDLPFC depends on concurrent task performance and individual head anatomy. In a randomised, sham-controlled, double-blind crossover study 22 healthy participants (10–17 years) received 2 mA multichannel anodal tDCS (atDCS) over the lDLPFC with and without a 2-back working memory (WM) task. After stimulation, the 2-back task and a Flanker task were performed. Resting state and task-related EEG were recorded. In 16 participants we calculated the individual electric field (E-field) distribution. Performance and neurophysiological activity in the 2-back task were not affected by atDCS. atDCS reduced reaction times in the Flanker task, independent of whether atDCS had been combined with the 2-back task. Flanker task related beta oscillation increased following stimulation without 2-back task performance. atDCS effects were not correlated with the E-field. We found no effect of multichannel atDCS over the lDLPFC on WM in children/adolescents but a transfer effect on interference control. While this effect on behaviour was independent of concurrent task performance, neurophysiological activity might be more sensitive to cognitive activation during stimulation. However, our results are limited by the small sample size, the lack of an active control group and variations in WM performance.

Left Dorsolateral Prefrontal Cortex Anodal tDCS Effects on Negative Symptoms in Schizophrenia

2015 ◽  
Vol 8 (5) ◽  
pp. 989-991 ◽  
Author(s):  
July Silveira Gomes ◽  
Pedro Shiozawa ◽  
Álvaro Machado Dias ◽  
Daniella Valverde Ducos ◽  
Henrique Akiba ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Dorsolateral Prefrontal Cortex ◽  
Negative Symptoms ◽  
Anodal Tdcs ◽  
Dorsolateral Prefrontal

scholarly journals Efficiency of Repetitive Transcranial Direct Current Stimulation of the Dorsolateral Prefrontal Cortex in Disorders of Consciousness: A Randomized Sham-Controlled Study

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Min Wu ◽  
Yamei Yu ◽  
Lunjie Luo ◽  
Yuehao Wu ◽  
Jian Gao ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Dorsolateral Prefrontal Cortex ◽  
Disorders Of Consciousness ◽  
Anodal Tdcs ◽  
Direct Current Stimulation ◽  
Dorsolateral Prefrontal ◽  
The Right ◽  
Stimulation Of

Conventional transcranial direct current stimulation (tDCS) targeting the left dorsolateral prefrontal cortex (DLPFC) could improve arousal in disorders of consciousness (DOC). However, the comparative effectiveness of anodal stimulation of the left DLPFC and the electrophysiological effect of tDCS are yet to be determined. In this randomized sham-controlled design, patients were separated into three groups (left/right anodal tDCS, sham). Data on the clinical assessments and EEG were collected at baseline and after 2 weeks of tDCS. The outcome at 3-month follow-up was evaluated using the Glasgow Outcome Scale-Extended. Results showed that sessions of the left tDCS facilitated the excitability of the prefrontal cortex, whereas only one patient had a positive outcome. Targeting the right DLPFC was less effective, merely leading to activation of the stimulation site, with no effect on the state of arousal. Moreover, sham stimulation had minimal or no effect on any of the outcomes. These results provide evidence for a hemispheric asymmetry of tDCS effects in patients with DOC. Left anodal tDCS might be more effective for modulating cortical excitability compared to tDCS on the right DLPFC. However, future studies with large sample sizes are needed to confirm these findings. This trial is registered with NCT03809936.

Differential dorsolateral prefrontal cortex activation during a verbal n-back task according to sensory modality

2009 ◽  
Vol 205 (1) ◽  
pp. 299-302 ◽  
Author(s):  
Roberto Rodriguez-Jimenez ◽  
Cesar Avila ◽  
Cristina Garcia-Navarro ◽  
Alexandra Bagney ◽  
Ana Martinez de Aragon ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Dorsolateral Prefrontal Cortex ◽  
Sensory Modality ◽  
Dorsolateral Prefrontal ◽  
Back Task

scholarly journals Anodal Transcranial Direct Current Stimulation-Induced Effects Over the Right Dorsolateral Prefrontal Cortex: Differences in the Task Types of Task Switching

2021 ◽  
Vol 12 ◽  
Author(s):  
Ziyu Wang ◽  
Rongjuan Zhu ◽  
Xuqun You
Keyword(s):  
Prefrontal Cortex ◽  
Task Switching ◽  
Dorsolateral Prefrontal Cortex ◽  
Switch Cost ◽  
Sham Group ◽  
Anodal Tdcs ◽  
Dorsolateral Prefrontal ◽  
The Right ◽  
Task Types ◽  
And Task

Transcranial direct current stimulation (tDCS) has been previously used to investigate the causal relationships between the dorsolateral prefrontal cortex (DLPFC) and task switching but has delivered inconclusive results that may be due to different switching tasks involving different cognitive control processes. In the current study, we manipulated task types and task predictability to investigate the role of DLPFC in task-switching performances. Notably, we distinguished the specific effects of anodal-tDCS on two types of tasks (parity/magnitude and parity/vowel-consonant tasks). Forty-eight participants were randomly assigned to four task groups as follows; Group I who was assigned right anode (RA) parity/magnitude tasks, Group II who were assigned sham parity/magnitude tasks, Group III who were assigned RA parity/vowel-consonant tasks, and Group IV who were assigned sham parity/vowel-consonant tasks. Participants were asked to complete both predictable and unpredictable tasks. In the parity/magnitude task, we demonstrated a lower switch cost for the RA group compared to the sham group for unpredictable tasks. In contrast, in the parity/vowel-consonant task, the switch cost was higher for the RA group compared to the sham group for unpredictable and predictable tasks. These findings confirmed an anodal-tDCS-induced effect over the right DLPFC both in the parity/magnitude and parity/vowel-consonant tasks. Our data indicated that anodal tDCS may have a stronger influence on task-switching performance over the right DLPFC by changing the irrelevant task-set inhibition process. Also, the right DLPFC is unlikely to act by performing exogenous adjustment of predictable task switching.

scholarly journals CAN TRANSCRANIAL DIRECT CURRENT STIMULATION OVER THE DORSOLATERAL PREFRONTAL CORTEX ENHANCE PROPRIOCEPTION?

2019 ◽  
Author(s):  
Eric N. Beck ◽  
Sankirtana Shankar Narayanan ◽  
Rian McDermott ◽  
Alice G. Witney
Keyword(s):  
Prefrontal Cortex ◽  
Direct Current ◽  
Sensorimotor Cortex ◽  
Motor Performance ◽  
Significant Interaction ◽  
Dorsolateral Prefrontal Cortex ◽  
Anodal Tdcs ◽  
Target Task ◽  
Left Dlpfc ◽  
Dorsolateral Prefrontal

ABSTRACTIntroductionProprioception (perception of one’s limb position) is critical for accurate and consistent movement, and is processed by the sensorimotor cortex. Increased prefrontal activity is associated with improved proprioception and motor performance. Anodal transcranial direct current stimulation (tDCS) of the left dorsolateral prefrontal cortex (DLPFC) has been found to increase activity of the sensorimotor cortex. Thus, this study aimed to investigate whether anodal tDCS of the DLPFC may enhance proprioception measured with a target task. It was hypothesized that tDCS over the left DLPFC would improve motor performance (error and variability) on a target task completed without vision.DesignSingle blind, within-participant, sham-controlled trial.MethodsFifteen healthy young adults (M:F=6:9, age=23.3 years) completed 18 trials of a computerized target task (manipulating a mouse) with their non-dominant upper-limb, with and without vision, before and after (pre/post assessment) 20-minutes of stimulation (anodal tDCS of the left DLPFC) and sham conditions. Averages and coefficient of variation (CV, variability between trials) of spatio-temporal parameters associated with the movement were measured. Stimulation/ sham sessions were counterbalanced (stimulation first session, n=8), with each session separated by one week. Repeated-measures ANOVA and pairwise comparisons (95% confidence intervals [CI]) were conducted.ResultsRegarding distance travelled CV, a significant interaction between condition and assessment (F(1,14)=5.09, p=0.041) demonstrated that variability was significantly less post-stimulation compared to pre (p=0.003). A significant interaction between assessment and vision (F(1,14)=30.08, p<0.001) regarding distance travelled CV showed that without vision, variability was significantly less at post compared to pre (p<0.001), and this decrease was found after the stimulation condition only (95% CI = Δ 7.4 +/− 1.6 [4.0 to 10.9]).ConclusionSince variability of distance travelled during the target task without vision was lower post-stimulation compared to pre, consistency of movement without vision, and therefore proprioception, may have been enhanced by anodal tDCS of the DLPFC. This improvement could be due to modulation of fronto-striatal-thalamic circuits. These findings may be the first step in developing tDCS methods as an effective adjunct therapy for dysfunctional proprioception in various disorders, such as Parkinson’s disease.

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