scholarly journals Investigations on the potential of optical coherence tomography as an imaging tool for eustachian tube

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xiao-Mei Sun ◽  
Jia-Qi Luo ◽  
Zhi-Wen Xiao ◽  
Qing-Yu Gu ◽  
Lin-Chan Lan ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Adverse Events ◽  
Eustachian Tube ◽  
Diagnostic Value ◽  
Optical Coherence ◽  
Imaging Tool ◽  
Pharyngeal Region ◽  
The Mean ◽  
Oct Imaging ◽  
Different Characteristics

AbstractThe purpose of this study was to explore the feasibility of eustachian tube optical coherence tomography (ET-OCT) for imaging the pharyngeal region of the eustachian tube (ET). Ten subjects with ear complaints underwent ET-OCT guided by nasal endoscopy, and ET-OCT examination was performed on both sides of each subject's ETs. The process and resulting images were analysed. Ten subjects ranging from 21 to 73 years old (45 ± 14.77) were enrolled in this study. Eighteen ET-OCT imaging examinations were completed. The mean duration of each examination was 2.80 ± 1.62 min (ranging from 2 to 7 min). There were no adverse events or complications. In some subjects, the ET-OCT images clearly presented the microstructures of the ET wall, including the lumen, mucosa, submucosa, cartilage and plica. However, in some subjects, it showed different characteristics, such as an unclear hierarchy and secretions in the lumen. ET-OCT may help to distinguish the structural composition of the ET and elucidate related pathophysiological mechanisms. It is a valuable imaging tool suited for the ET, with potential diagnostic value in determining the morphology of the lumen, intraluminal mucosa and submucosal tissue in the pharyngeal region of the ET.

scholarly journals Investigations on the Potential of Optical Coherence Tomography as an Imaging Tool for Eustachian Tube

2020 ◽  
Author(s):  
Mei Sun ◽  
Qi Luo ◽  
Wen Xiao ◽  
Yu Gu ◽  
Chan Lan ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Eustachian Tube ◽  
Diagnostic Value ◽  
Pathophysiological Mechanism ◽  
Optical Coherence ◽  
Imaging Tool ◽  
Operation Process ◽  
Pharyngeal Region ◽  
Oct Imaging ◽  
Different Characteristics

Abstract The purpose of this study was to explore the feasibility of eustachian tube optical coherence tomography (ET-OCT) for the pharyngeal region of the eustachian tube. Ten subjects with ear complaint accepted ET-OCT with the guidance of nasal endoscopy, and ET-OCT examination was performed on both sides of each subject's eustachian tubes. Operation process and images were analyzed. 10 subjects ranged from 21 to 73 years old (45 ± 14.77) were enrolled in this study. Eighteen ET-OCT imaging were completed. The mean duration of each examination was 2.80 ± 1.62 min (ranged from 2 to 7min). There was no adverse event or complication. In some subjects, the ET-OCT images presented clear eustachian tube wall microstructure, including distinct lumen, mucosa, submucosa, cartilage and plica. But in some subjects, it showed different characteristics, such as unclear hierarchy, secretions in the lumen. ET-OCT may help to distinguish eustachian tube structural composition and elucidate its pathophysiological mechanism. It is a valuable imaging tool suit for the eustachian tube, and it shows potential diagnostic value in determining luminal morphology, intraluminal mucosa and submucosal tissue in the pharyngeal region of the eustachian tube.

Intraluminal three-dimensional optical coherence tomography – a tool for imaging of the Eustachian tube?

2019 ◽  
Vol 133 (2) ◽  
pp. 87-94 ◽  
Author(s):  
R Schuon ◽  
B Mrevlje ◽  
B Vollmar ◽  
T Lenarz ◽  
G Paasche
Keyword(s):  
Optical Coherence Tomography ◽  
Eustachian Tube ◽  
Cross Sections ◽  
Ex Vivo ◽  
Three Dimensional ◽  
Diagnostic Value ◽  
Optical Coherence ◽  
Experimental Conditions ◽  
Non Invasive ◽  
Tube Dysfunction

AbstractObjectivesThe cause of Eustachian tube dysfunction often remains unclear. Therefore, this study aimed to examine the feasibility and possible diagnostic use of optical coherence tomography in the Eustachian tube ex vivo.MethodsTwo female blackface sheep cadaver heads were examined bilaterally. Three conditions of the Eustachian tube were investigated: closed (resting position), actively opened and stented. The findings were compared (and correlated) with segmented histological cross-sections.ResultsIntraluminal placement of the Eustachian tube with the optical coherence tomography catheter was performed without difficulty. Regarding the limited infiltration depth of optical coherence tomography, tissues can be differentiated. The localisation of the stent was accurate as was the lumen.ConclusionThe application of optical coherence tomography in the Eustachian tube under these experimental conditions is considered to be a feasible, rapid and non-invasive diagnostic method, with possible diagnostic value for determining the luminal shape and superficial lining tissue of the Eustachian tube.

scholarly journals A Post-market, Multi-vessel Evaluation of the Imaging of Peripheral Arteries for Diagnostic PurposeS Comparing Optical Coherence TomogrAphy and INtravascular Ultrasound Imaging (SCAN)

2020 ◽  
Author(s):  
Edward Pavillard ◽  
Luke Sewell
Keyword(s):  
Optical Coherence Tomography ◽  
Vascular Disease ◽  
Intravascular Ultrasound ◽  
Treatment Strategy ◽  
Imaging Systems ◽  
Imaging Modalities ◽  
Optical Coherence ◽  
Luminal Diameter ◽  
The Mean ◽  
Oct Imaging

Abstract Background: Intravascular imaging plays an important part in diagnosis of vascular conditions and providing insight for treatment strategy. Two main imaging modalities are intravascular ultrasound (IVUS) and optical coherence tomography (OCT). The objective of this study was to prove non-inferiority of OCT imaging to IVUS images in matched segments of peripheral vessels in patients with suspected peripheral vascular disease. Methods: The SCAN study was a prospective, non-inferiority clinical study of matched IVUS and OCT images collected along defined segments of peripheral vessels from twelve subjects (mean age 68 10.3 years; 10 men) displaying symptoms of vascular disease. Luminal diameters were measured by both imaging systems at the distal, middle, and proximal points of the defined segments. Three blinded interventional radiologists evaluated the quality of both imaging modalities in identifying lMann-Whitney-Wilcoxon testing. Intrareader reproducibility was calculated by intraclass correlation (ICC) analysis. Results: The mean scoringof plaque, calcification, and vascular stent struts by the three readers was significant better in terms of image quality for OCT than IVUS (p<0.001, p=0.001, p=0.004, respectively). The mean scores of vessel wall component visibility and artifacts generated by the two imaging systems were not significantly different (p=0.19, p=0.07, respectively). Mean vessel luminal diameter and area at three specific locations within the vessels were not significantly different between the two imaging modalities. No patient injury, adverse effect or device malfunction were noted during thestudy. Conclusions: Imaging byOCT provides the physician with better visualization of some vessel and plaque chacteristics, but both IVUS and OCT imaging are safe and effective methods of examining peripheral vessels in order to perform diagnostic assessment of peripheral vessels and provide information necessary for the treatment strategy of peripheral artery disease.

scholarly journals A Post-market, Multi-vessel Evaluation of the Imaging of Peripheral Arteries for Diagnostic Purposes Comparing Optical Coherence Tomography and Intravascular Ultrasound Imaging (SCAN)

2019 ◽  
Author(s):  
Edward Pavillard ◽  
Luke Sewell
Keyword(s):  
Optical Coherence Tomography ◽  
Intravascular Ultrasound ◽  
Treatment Strategy ◽  
Intraclass Correlation ◽  
Imaging Systems ◽  
Imaging Modalities ◽  
Optical Coherence ◽  
Luminal Diameter ◽  
The Mean ◽  
Oct Imaging

Abstract Background: Intravascular imaging plays an important part in diagnosis of vascular conditions and providing insight for treatment strategy. Two main imaging modalities are intravascular ultrasound (IVUS) and optical coherence tomography (OCT). The objective of this study was to prove non-inferiority of OCT imaging to IVUS images in matched segments of peripheral vessels in patients with suspected peripheral vascular disease.Methods: The SCAN study was a prospective, non-inferiority clinical study of matched IVUS and OCT images collected along defined segments of peripheral vessels from twelve subjects (mean age 68 10.3 years; 10 men) displaying symptoms of vascular disease. Luminal diameters were measured by both imaging systems at the distal, middle, and proximal points of the defined segments. Three blinded interventional radiologists evaluated the quality of both imaging modalities in identifying lMann-Whitney-Wilcoxon testing. Intrareader reproducibility was calculated by intraclass correlation (ICC) analysis. Results: The mean scoringof plaque, calcification, and vascular stent struts by the three readers was significant better in terms of image quality for OCT than IVUS (p<0.001, p=0.001, p=0.004, respectively). The mean scores of vessel wall component visibility and artifacts generated by the two imaging systems were not significantly different (p=0.19, p=0.07, respectively). Mean vessel luminal diameter and area at three specific locations within the vessels were not significantly different between the two imaging modalities. No patient injury, adverse effect or device malfunction were noted during thestudy. Conclusions: Imaging byOCT provides the physician with better visualization of some vessel and plaque chacteristics, but both IVUS and OCT imaging are safe and effective methods of examining peripheral vessels in order to perform diagnostic assessment of peripheral vessels and provide information necessary for the treatment strategy of peripheral artery disease.

scholarly journals White Thrombosis on Optical Coherence Tomography after Rotational Atherectomy of Severely Coronary Calcified Lesions

2020 ◽  
Author(s):  
Cheng-fu CAO ◽  
Yu-liang MA ◽  
Qi LI ◽  
Jian LIU ◽  
Hong ZHAO ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Platelet Activation ◽  
Stent Implantation ◽  
Rotational Atherectomy ◽  
Control Group ◽  
Optical Coherence ◽  
Burr Size ◽  
No Reflow ◽  
The Mean ◽  
Oct Imaging

Abstract Background: Rotational atherectomy (RA) has improved percutaneous treatment of severe coronary calcified lesions, but the "no-reflow" phenomenon remains a serious complication. Platelet activation by RA may contribute to the no-reflow, we use optical coherence tomography (OCT) to test the effect of RA on white thrombosis that could confirm platelet activation indirectly. Methods: We analyzed 53 consecutive patients with coronary angiographic severe calcified lesions. All the patients were examined by OCT. Twenty patients received RA and OCT imaging performed before and after RA and after stent implantation. The remaining patients were as a control group and OCT imaging performed before balloon dilatation and after stent implantation. Results: The patients were older and higher incidence of Diabetes mellitus in the RA group. In the RA group, the mean burr size was 1.48±0.14mm. The mean rotation speed was 152,300±4,200rpm. The mean number of rotations per patient was 5.3±2.1 times and the mean ablation time per RA was 11.3±3.2 seconds. In the control group, there was no thrombogenesis during the procedure, but in the RA group, all the target vessels had only white thrombosis on OCT after RA. The average number of white thrombus per lesion after RA was 7.23±4.4, and the average length of every white thrombus was 0.51±0.33mm. In Pearson Correlation Analysis, Thrombotic load was related with burr size (r=0.575, P=0.040) and rotation number (r=0.599, P=0.031).Conclusions: White thrombosis during RA is proved by OCT in vivo. Treating calcified lesions with RA may enhance thrombogenesis. These data suggest using a proper therapy to avoid no-reflow during RA.

scholarly journals The Diagnostic Value of Pulsar Perimetry, Optical Coherence Tomography, and Optical Coherence Tomography Angiography in Pre-Perimetric and Perimetric Glaucoma

2021 ◽  
Vol 10 (24) ◽  
pp. 5825
Author(s):  
Hung-Chih Chen ◽  
Michael Chia-Yen Chou ◽  
Ming-Tsung Lee ◽  
Chia-Yi Lee ◽  
Che-Ning Yang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Ganglion Cell ◽  
Optical Coherence Tomography Angiography ◽  
Diagnostic Value ◽  
Vessel Density ◽  
Control Group ◽  
Ganglion Cell Complex ◽  
Optical Coherence ◽  
The Mean ◽  
Sensitive Parameters

The purpose of this article is to investigate the diagnostic value of Pulsar perimetry (PP), optical coherence tomography (OCT), and optical coherence tomography angiography (OCTA) in pre-perimetric glaucoma (PPG) and perimetric glaucoma (PG). This retrospective cross-sectional study included 202 eyes (145 eyes in the control group, 40 eyes in the PPG group, and 17 eyes in the PG group) from 105 subjects. The results were analyzed by paired t-tests and Wilcoxon signed-rank test. The area under the curve (AUC), sensitivity, and specificity were used to evaluate the diagnostic accuracy. Pearson correlation was used to investigate the relationships of each parameter. The most sensitive parameters for differentiating the control group from the PPG group by using Pulsar, OCT, and OCTA were square loss variance of PP (AUC = 0.673, p < 0.001), superior ganglion cell complex thickness (AUC = 0.860, p < 0.001), and superior-hemi retina thickness (AUC = 0.817, p < 0.001). In the PG group, the most sensitive parameters were mean defect of PP (AUC = 0.885, p < 0.001), whole image of ganglion cell complex thickness (AUC = 0.847, p < 0.001), and perifoveal retina thickness (AUC = 0.833, p < 0.001). The mean defect of PP was significantly correlated with vascular parameters (radial peripapillary capillary (RPC), p = 0.008; vessel density of macular superficial vascular complex (VDms), p = 0.001; vessel density of macular deep vascular complex (VDmd), p = 0.002). In conclusion, structural measurements using OCT were more sensitive than vascular measurements of OCTA and functional measurements of PP for PPG, while PP was more sensitive than the structural and vascular measurements for PG. The mean defect of PP was also shown to be highly correlated with the reduction of vessel density.

Blood Vessel Density Measured Using Dynamic Optical Coherence Tomography is a Tool for Wound Healers

2021 ◽  
pp. 153473462110173
Author(s):  
Rajgopal Mani ◽  
Jon Holmes ◽  
Kittipan Rerkasem ◽  
Nikolaos Papanas
Keyword(s):  
Blood Flow ◽  
Optical Coherence Tomography ◽  
Blood Vessel ◽  
Chronic Wounds ◽  
Vessel Density ◽  
Optical Coherence ◽  
Skin Microcirculation ◽  
Wound Edge ◽  
Venous Ulcers ◽  
Oct Imaging

Dynamic optical coherence tomography (D-OCT) is a relatively new technique that may be used to study the substructures in the retina, in the skin and its microcirculation. Furthermore, D-OCT is a validated method of imaging blood flow in skin microcirculation. The skin around venous and mixed arterio-venous ulcers was imaged and found to have tortuous vessels assumed to be angiogenic sprouts, and classified as dots, blobs, coils, clumps, lines, and curves. When these images were analyzed and measurements of vessel density were made, it was observed that the prevalence of coils and clumps in wound borders was significantly greater compared with those at wound centers. This reinforced the belief of inward growth of vessels from wound edge toward wound center which, in turn, reposed confidence in following the wound edge to study healing. D-OCT imaging permits the structure and the function of the microcirculation to be imaged, and vessel density measured. This offers a new vista of skin microcirculation and using it, to better understand angiogenesis in chronic wounds.

Feasibility and Clinical Utility of Ultra-Widefield–Navigated Swept-Source Optical Coherence Tomography Imaging

2021 ◽  
pp. 247412642199733
Author(s):  
Kyle D. Kovacs ◽  
M. Abdallah Mahrous ◽  
Luis Gonzalez ◽  
Benjamin E. Botsford ◽  
Tamara L. Lenis ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Clinical Utility ◽  
Clinical Decision Making ◽  
Imaging System ◽  
Imaging Modality ◽  
Case Series ◽  
Subretinal Fluid ◽  
Optical Coherence ◽  
Swept Source ◽  
Oct Imaging

Purpose: This work aims to evaluate the clinical utility and feasibility of a novel scanning laser ophthalmoscope-based navigated ultra-widefield swept-source optical coherence tomography (UWF SS-OCT) imaging system. Methods: A retrospective, single-center, consecutive case series evaluated patients between September 2019 and October 2020 with UWF SS-OCT (modified Optos P200TxE, Optos PLC) as part of routine retinal care. The logistics of image acquisition, interpretability of images captured, nature of the peripheral abnormality, and clinical utility in management decisions were recorded. Results: Eighty-two eyes from 72 patients were included. Patients were aged 59.4 ± 17.1 years (range, 8-87 years). During imaging, 4.4 series of images were obtained in 4.1 minutes, with 86.4% of the image series deemed to be diagnostic of the peripheral pathology on blinded image review. The most common pathologic findings were chorioretinal scars (18 eyes). In 31 (38%) eyes, these images were meaningful in supporting clinical decision-making with definitive findings. Diagnoses imaged included retinal detachment combined with retinoschisis, retinal hole with overlying vitreous traction and subretinal fluid, vitreous inflammation overlying a peripheral scar, Coats disease, and peripheral retinal traction in sickle cell retinopathy. Conclusions: Navigated UWF SS-OCT imaging was clinically practical and provided high-quality characterization of peripheral retinal lesions for all eyes. Images directly contributed to management plans, including laser, injection or surgical treatment, for a clinically meaningful set of patients (38%). Future studies are needed to further assess the value of this imaging modality and its role in diagnosing, monitoring, and treating peripheral lesions.

scholarly journals Diagnostic value of optical coherence tomography angiography for choroidal neovascularization in age-related macular degeneration: A systematic review and meta-analysis

2020 ◽  
Author(s):  
Chang-Xi Chen ◽  
Mei-Ling Liu ◽  
Kai Cao ◽  
Mayinuer Yusufu ◽  
Jin-Da Wang
Keyword(s):  
Systematic Review ◽  
Optical Coherence Tomography ◽  
Macular Degeneration ◽  
Choroidal Neovascularization ◽  
Optical Coherence Tomography Angiography ◽  
Meta Analysis ◽  
Diagnostic Value ◽  
Age Related Macular Degeneration ◽  
Optical Coherence ◽  
Classification Rate

Objective: To evaluate the diagnostic value of optical coherence tomography angiography (OCTA) in detecting the choroidal neovascularization (CNV) in agerelated macular degeneration (AMD). Methods: A systematic review and meta-analysis was performed by searching Pubmed, Science Direct, Embase and Web of Science. The pooled sensitivity and specificity with 95% confidence intervals (CIs), area under the summary receiver operator characteristic curve (sROC), and the total accurate classification rate were used to evaluate OCTA’ diagnostic value of CNV in AMD patients. Results: Seven studies involving 517 eyes were included in the analysis. The mean age of subjects in each study ranged from 58.5 years to 81.7 years. Fluorescein angiography was applied as the gold standard in five studies. There were 350 eyes diagnosed with CNV, OCTA detected 301 eyes correctly, while among the 167 eyes without CNV, OCTA identified 150 correctly. The total accurate classification rate was 87.23%. The Spearman's rank correlation coefficient was 0.5, indicating that there was no significant threshold effect in the current study (S=8, p=0.103). The pooled sensitivity and pooled specificity were 0.89 (95%CI: 0.82,0.94) and 0.96 (95%CI: 0.85,1.00) respectively. The area under sROC was up to 0.911. Conclusion: The specificity of OCTA for the detection of CNV in AMD patients is extremely high, however, the sensitivity still needs to be improved. In general, the metaanalysis revealed that OCTA had a high diagnostic value for the detection of CNV in AMD patients.

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