scholarly journals Atypical electrophysiological and behavioral responses to diazepam in a leading mouse model of Down syndrome

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Daniella B. Victorino ◽  
Daniel J. L. L. Pinheiro ◽  
Jonah J. Scott-McKean ◽  
Sarah Barker ◽  
Melissa R. Stasko ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Mouse Model ◽  
Brain Activity ◽  
Long Term Potentiation ◽  
Term Potentiation ◽  
Plus Maze ◽  
Underlying Causes ◽  
Pre Treatment ◽  
And Behavior

AbstractMounting evidence implicates dysfunctional GABAAR-mediated neurotransmission as one of the underlying causes of learning and memory deficits observed in the Ts65Dn mouse model of Down syndrome (DS). The specific origin and nature of such dysfunction is still under investigation, which is an issue with practical consequences to preclinical and clinical research, as well as to the care of individuals with DS and anxiety disorder or those experiencing seizures in emergency room settings. Here, we investigated the effects of GABAAR positive allosteric modulation (PAM) by diazepam on brain activity, synaptic plasticity, and behavior in Ts65Dn mice. We found Ts65Dn mice to be less sensitive to diazepam, as assessed by electroencephalography, long-term potentiation, and elevated plus-maze. Still, diazepam pre-treatment displayed typical effectiveness in reducing susceptibility and severity to picrotoxin-induced seizures in Ts65Dn mice. These findings fill an important gap in the understanding of GABAergic function in a key model of DS.

scholarly journals The Down Syndrome Critical Region Protein RCAN1 Regulates Long-Term Potentiation and Memory via Inhibition of Phosphatase Signaling

2007 ◽  
Vol 27 (48) ◽  
pp. 13161-13172 ◽  
Author(s):  
C. A. Hoeffer ◽  
A. Dey ◽  
N. Sachan ◽  
H. Wong ◽  
R. J. Patterson ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Critical Region ◽  
Long Term Potentiation ◽  
Term Potentiation

scholarly journals IL-37 expression reduces acute and chronic neuroinflammation and rescues cognitive impairment in an Alzheimer s disease mouse model

2021 ◽  
Author(s):  
Niklas Lonnemann ◽  
Shirin Hosseini ◽  
Melanie Ohm ◽  
Karsten Hiller ◽  
Charles A. Dinarello ◽  
...  
Keyword(s):  
Mouse Model ◽  
Cognitive Abilities ◽  
Long Term Potentiation ◽  
Spine Density ◽  
Chronic Neuroinflammation ◽  
Model Of Alzheimer’S Disease ◽  
Term Potentiation ◽  
Anti Inflammatory ◽  
And Function ◽  
And Behavior

The anti-inflammatory cytokine interleukin-37 (IL-37) is a member of the IL-1 family but not expressed in mice. We used a human IL 37 (hIL-37tg) expressing mouse, which has been subjected to various models of local and systemic inflammation as well as immunological challenges. Those studies demonstrate an immune-modulatory role of IL-37 which can be characterized as an important suppressor of innate immunity. We investigated the functions of IL-37 in the CNS and explored the effects of IL-37 on neuronal architecture and function, microglia phenotype, cytokine production and behavior after inflammatory challenge by intraperitoneal LPS-injection. Reduced spine density, activated microglia phenotype and impaired long-term potentiation (LTP) were observed in wild-type mice after LPS injection, whereas hIL-37tg mice showed no impairment. In addition, we crossed the hIL-37tg mouse with an animal model of Alzheimer's disease (APP/PS1) to investigate the anti-inflammatory properties of IL-37 under chronic neuroinflammatory conditions. Our results show that IL-37 is able to limit inflammation in the brain after acute inflammatory events and prevent the loss of cognitive abilities in a mouse model of AD.

scholarly journals The reemergence of long-term potentiation in aged Alzheimer’s disease mouse model

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Seonghoo Huh ◽  
Soo-Ji Baek ◽  
Kyung-Hwa Lee ◽  
Daniel J. Whitcomb ◽  
Jihoon Jo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Long Term Potentiation ◽  
Term Potentiation
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