scholarly journals Author Correction: Enlarged periventricular space and periventricular lesion extension on baseline brain MRI predicts poor neurological outcomes in cryptococcus meningoencephalitis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Woo‑Jin Lee ◽  
Young Jin Ryu ◽  
Jangsup Moon ◽  
Soon‑Tae Lee ◽  
Keun‑Hwa Jung ◽  
...  
Keyword(s):  
Brain Mri ◽  
Neurological Outcomes ◽  
Lesion Extension ◽  
Periventricular Lesion

Outcomes of Cryptococcus meningoencephalitis and associated magnetic resonance imaging findings

2020 ◽  
Author(s):  
Woo-Jin Lee ◽  
Young Jin Ryu ◽  
Jangsup Moon ◽  
Soon-Tae Lee ◽  
Keun-Hwa Jung ◽  
...  
Keyword(s):  
Disease Progression ◽  
Brain Mri ◽  
Area Under The Curve ◽  
Mri Findings ◽  
Neurological Outcomes ◽  
Lesion Extension ◽  
Poor Outcomes ◽  
Periventricular Lesion ◽  
Score Range ◽  
Serial Brain

Abstract In Cryptococcus Neoformans meningoencephalitis, brain MRI findings might reflect the phathomechanism of disease progression that is fungal accumulation in the peri-venular space and consequent invasion into the parenchyma. This study analyzed serial brain MRI findings of 76 patients with cryptococcus meningoencephalitis in association with the disease progression and outcomes. MRI parameters included the enlarged periventricular space (ePVS) score (range 0 − 8), periventricular lesion extension, cryptococcoma, and hydrocephalus. Clinical outcomes at 2-week, 10-week, and 6-month were evaluated using modified Rankin scale (mRS) scores. At 6 months, 15 (19.7%) patient died and 34 (44.1%) had poor neurological outcomes (mRS scores > 2). At baseline, an ePVS score of ≥ 5 (Odds-ratio [OR]: 94.173, 95% confidence-interval [95% CI]: 7.507 − 1181.295, P < 0.001), periventricular lesion extension (OR: 51.965, 95% CI: 2.592 − 1041.673, P = 0.010), and presence of encephalitis feature (OR: 44.487, 95% CI: 1.689 − 1172.082, P = 0.023) were associated with 6-month poor outcomes. Presence of two or more risk factors at baseline was highly associated with the 6-month poor outcomes (area under the curve [AUC]: 0.978, P < 0.001) and mortality (AUC: 0.836, P < 0.001). Disease progression was associated with interval development of cryptococcoma and hydrocephalus. In conclusion, brain MRI findings might be useful in predicting poor outcomes and monitoring the disease progression of cryptococcus meningoencephalitis.

scholarly journals Enlarged periventricular space and periventricular lesion extension on baseline brain MRI predicts poor neurological outcomes in cryptococcus meningoencephalitis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Woo-Jin Lee ◽  
Young Jin Ryu ◽  
Jangsup Moon ◽  
Soon-Tae Lee ◽  
Keun-Hwa Jung ◽  
...  
Keyword(s):  
Disease Progression ◽  
Brain Mri ◽  
Area Under The Curve ◽  
Mri Findings ◽  
Neurological Outcomes ◽  
Lesion Extension ◽  
Poor Outcomes ◽  
Periventricular Lesion ◽  
Score Range ◽  
Serial Brain

AbstractIn Cryptococcus neoformans meningoencephalitis, brain MRI findings might reflect the phathomechanism of disease progression that is fungal accumulation in the peri-venular space and consequent invasion into the parenchyma. This study analyzed serial brain MRI findings of 76 patients with cryptococcus meningoencephalitis in association with the disease progression and outcomes. MRI parameters included the enlarged periventricular space (ePVS) score (range 0–8), periventricular lesion extension, cryptococcoma, and hydrocephalus. Clinical outcomes at 2-week, 10-week, and 6-month were evaluated using modified Rankin scale (mRS). At 6 months, 15 (19.7%) patients died and 34 (44.1%) had poor neurological outcomes (mRS scores > 2). At baseline, an ePVS score of ≥ 5 (Odds-ratio [OR]: 94.173, 95% confidence-interval [95%CI]: 7.507–1181.295, P < .001), periventricular lesion extension (OR: 51.965, 95%CI: 2.592–1041.673, P = .010), and presence of encephalitis feature (OR: 44.487, 95%CI: 1.689–1172.082, P = .023) were associated with 6-month poor outcomes. Presence of two or more risk factors among encephalitis feature, ePVS score ≥ 5, and periventricular lesion extension at baseline, was associated with 6-month poor outcomes (area under the curve [AUC]: 0.978, P < .001) and mortality (AUC: 0.836, P < .001). Disease progression was associated with interval development of cryptococcoma and hydrocephalus. Brain MRI findings might be useful in predicting outcomes and monitoring the progression of cryptococcus meningoencephalitis.

Reliability of Hammersmith Examination in Prediction of Neurological Outcomes (REHAPENO) - Research Protocol (Preprint)

2018 ◽  
Author(s):  
Mohamed Fleifel ◽  
Rawya Abdelghani ◽  
Mohamed Ameen
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Image ◽  
Current Practice ◽  
Surgical Intervention ◽  
Brain Mri ◽  
Developmental Outcomes ◽  
Research Protocol ◽  
Neurological Outcomes ◽  
Mri Brain ◽  
Brain Ultrasound

BACKGROUND Background: Studying the neurological developmental outcomes and comparing correlations with MRI (Magnetic resonance image) versus the Hammersmith Infant Neurological Examination (HINE) OBJECTIVE Objective: To investigate the non-inferiority of MRI to HINE in infant developmental outcomes METHODS Settings: Hospital settings including pediatrics and neonatal care units Intervention: No medical or surgical intervention is planned, only correlation and extra analyses would take place to standardize the current practice Measurements: HINE, Brain MRI, Brain Ultrasound and developmental outcomes after 12 months RESULTS Results: The observations collected and correlations measured to figure out the reliability of both HINE and MRI in order to figure to what extent can we rely on HINE alone in expecting the developmental outcomes CONCLUSIONS The more reliability would expressed by HINE assessment the accurate expectation of developmental in preterm infants CLINICALTRIAL https://clinicaltrials.gov/ct2/show/NCT03580252

scholarly journals Brain MRI Radiomics Analysis of School-Aged Children with Tetralogy of Fallot

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Yiwei Pu ◽  
Songmei Li ◽  
Siyu Ma ◽  
Yuanli Hu ◽  
Qinghui Hu ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Roc Curve ◽  
Functional Outcomes ◽  
Brain Mri ◽  
Imaging Biomarkers ◽  
Lasso Regression ◽  
Final Model ◽  
Neurological Outcomes ◽  
School Aged Children ◽  
Conventional Mri

Introduction. Radiomics could be potential imaging biomarkers by capturing and analyzing the features. Children and adolescents with CHD have worse neurodevelopmental and functional outcomes compared with their peers. Early diagnosis and intervention are the necessity to improve neurological outcomes in CHD patients. Methods. School-aged TOF patients and their healthy peers were recruited for MRI and neurodevelopmental assessment. LASSO regression was used for dimension reduction. ROC curve graph showed the performance of the model. Results. Six related features were finally selected for modeling. The final model AUC was 0.750. The radiomics features can be potential significant predictors for neurodevelopmental diagnoses. Conclusion. The radiomics on the conventional MRI can help predict the neurodevelopment of school-aged children and provide parents with rehabilitation advice as early as possible.

Neurodevelopmental outcome following hypoxic ischaemic encephalopathy and therapeutic hypothermia is related to right ventricular performance at 24-hour postnatal age

2021 ◽  
pp. fetalneonatal-2020-321463
Author(s):  
Regan E Giesinger ◽  
Amr I El Shahed ◽  
Michael P Castaldo ◽  
Adrianne R Bischoff ◽  
Vann Chau ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Therapeutic Hypothermia ◽  
Infant Development ◽  
Adverse Outcome ◽  
Brain Mri ◽  
Neurodevelopmental Outcome ◽  
Ventricular Performance ◽  
Neurological Outcomes ◽  
Right Ventricular Performance ◽  
Rv Function

ObjectiveOur aim was to determine whether right ventricular (RV) dysfunction at 24-hour postnatal age predicts adverse developmental outcome among patients with hypoxic ischaemic encephalopathy (HIE) undergoing therapeutic hypothermia (TH).DesignNeonates≥35 weeks with HIE/TH were enrolled in a physiological study in the neonatal period (n=46) and either died or underwent neurodevelopmental follow-up at 18 months (n=43). The primary outcome was a composite of death, diagnosis of cerebral palsy or any component of the Bayley Scores of Infant Development III<70. We hypothesised that tricuspid annulus plane systolic excursion (TAPSE) <6 mm and/or RV fractional area change (RV-FAC) <0.29 would predict adverse outcome.ResultsNine patients died and 34 patients were followed up at a mean age of 18.9±1.4 months. Both indices of RV systolic performance were abnormal in 15 (35%) patients, TAPSE <6 mm only was abnormal in 4 (9%) patients and RV-FAC <0.29 only was abnormal in 5 (12%) patients (19 had with normal RV function). Although similar at admission, neonates with RV dysfunction had higher cardiovascular and neurological illness severity by 24 hours than those without and severe MRI abnormalities (70% vs 53%, p=0.01) were more common. On logistic regression, TAPSE <6 mm (OR 3.6, 95% CI 1.2 to 10.1; p=0.017) and abnormal brain MRI [OR 21.7, 95% CI 1.4 to 336; p=0.028) were independently associated with adverse outcome. TAPSE <6 mm predicted outcome with a 91% sensitivity and 81% specificity.ConclusionsThe role of postnatal cardiovascular function on neurological outcomes among patients with HIE who receive TH merits further study. Quantitative measurement of RV function at 24 hours may provide an additional neurological prognostic tool.

USEFULNESS OF BRAIN MRI IN DIAGNOSIS OF NBIA IN PKAN AND NON-PKAN PATIENTS

2006 ◽  
Vol 37 (S 1) ◽  
Author(s):  
T Kmiec ◽  
E Jurkiewicz ◽  
S Jozwiak ◽  
I Pakula-Kosciesza ◽  
M Ebhart ◽  
...  
Keyword(s):  
Brain Mri

Neurological Outcomes After Carotid Stenting Protected With the NeuroShield Filter Compared to Unprotected Stenting

2002 ◽  
Vol 9 (6) ◽  
pp. 777-785 ◽  
Author(s):  
Sumaira Macdonald ◽  
Fiona McKevitt ◽  
Graham S. Venables ◽  
Trevor J. Cleveland ◽  
Peter A. Gaines
Keyword(s):  
Carotid Stenting ◽  
Neurological Outcomes

Brain MRI-findings in Ph - negative myeloproliferative disorders

2019 ◽  
Vol 91 (7) ◽  
pp. 29-34 ◽  
Author(s):  
M M Tanashyan ◽  
A L Melikyan ◽  
P I Kuznetsova ◽  
A A Raskurazhev ◽  
A A Shabalina ◽  
...  
Keyword(s):  
Cerebrovascular Disease ◽  
Sinus Thrombosis ◽  
Cerebral Arteries ◽  
Brain Mri ◽  
Myeloproliferative Disorders ◽  
Cerebral Venous Sinus Thrombosis ◽  
Mri Findings ◽  
Cerebral Lesions ◽  
Cerebrovascular Pathology ◽  
Underlying Mechanisms

Myeloproliferative disorders (MPD) are accompanied by a high proportion of thrombotic complications, which may lead to cerebrovascular disease (CVD). Aim. To describe MRI-findings in patients with Ph - negative MPD and evaluate any cerebrovascular disease. Materials and methods. We included 104 patients with Ph - negative MPD (age varied between 20 and 58) with clinical correlates of cerebrovascular pathology. Results. Brain MRI showed post - stroke lesions in 20% of patients (7 hemispheric infarcts due to thrombotic occlusion of one of the large cerebral arteries, 14 - cortical infarcts). 37 patients (36%) had vascular cerebral lesions. Cerebral venous sinus thrombosis occurred in 5 patients - in 7% (n=3) of patients with polycythemia vera and 5% (n=2) - in patients with essential thrombocythemia. The incidence of vascular cerebral lesions was associated with higher levels of the following: erythrocyte, platelet count, fibrinogen, and with the decrease in fibrinolytic activity, as well. Conclusion. The pioneering results of the study include the description and analysis of brain MRI-findings in patients with Ph - negative MPD. The underlying mechanisms of cerebrovascular pathology in these patients are associated with certain blood alterations (particularly, hemorheology) which present a major risk factor.

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