scholarly journals Enhancing studies of the connectome in autism using the autism brain imaging data exchange II

2017 ◽  
Vol 4 (1) ◽  
Author(s):  
Adriana Di Martino ◽  
David O’Connor ◽  
Bosi Chen ◽  
Kaat Alaerts ◽  
Jeffrey S. Anderson ◽  
...  
2018 ◽  
Vol 83 (7) ◽  
pp. 579-588 ◽  
Author(s):  
Nicolas Traut ◽  
Anita Beggiato ◽  
Thomas Bourgeron ◽  
Richard Delorme ◽  
Laure Rondi-Reig ◽  
...  

2013 ◽  
Vol 19 (6) ◽  
pp. 659-667 ◽  
Author(s):  
A Di Martino ◽  
C-G Yan ◽  
Q Li ◽  
E Denio ◽  
F X Castellanos ◽  
...  

2019 ◽  
Author(s):  
Yafeng Zhan ◽  
Jianze Wei ◽  
Jian Liang ◽  
Xiu Xu ◽  
Ran He ◽  
...  

AbstractPsychiatric disorders often exhibit shared (co-morbid) symptoms, raising controversies over accurate diagnosis and the overlap of their neural underpinnings. Because the complexity of data generated by clinical studies poses a formidable challenge, we have pursued a reductionist framework using brain imaging data of a transgenic primate model of autism spectrum disorder (ASD). Here we report an interpretable cross-species machine learning approach which extracts transgene-related core regions in the monkey brain to construct the classifier for diagnostic classification in humans. The cross-species classifier based on core regions, mainly distributed in frontal and temporal cortex, identified from the transgenic primate model, achieved an accuracy of 82.14% in one clinical ASD cohort obtained from Autism Brain Imaging Data Exchange (ABIDE-I), significantly higher than the human-based classifier (61.31%, p < 0.001), which was validated in another independent ASD cohort obtained from ABIDE-II. Such monkey-based classifier generalized to achieve a better classification in obsessive-compulsive disorder (OCD) cohorts, and enabled parsing of differential connections to right ventrolateral prefrontal cortex being attributable to distinct traits in patients with ASD and OCD. These findings underscore the importance of investigating biologically homogeneous samples, particularly in the absence of real-world data adequate for deconstructing heterogeneity inherited in the clinical cohorts.One Sentence SummaryFeatures learned from transgenic monkeys enable improved diagnosis of autism-related disorders and dissection of their underlying circuits.


2021 ◽  
Author(s):  
Elise Bannier ◽  
Gareth Barker ◽  
Valentina Borghesani ◽  
Nils Broeckx ◽  
Patricia Clement ◽  
...  

Author(s):  
Tewodros Mulugeta Dagnew ◽  
Letizia Squarcina ◽  
Massimo W. Rivolta ◽  
Paolo Brambilla ◽  
Roberto Sassi

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