The eukaryotic initiation factor 4E-binding proteins and apoptosis

2005 ◽  
Vol 12 (6) ◽  
pp. 541-546 ◽  
Author(s):  
C G Proud
Keyword(s):  
Binding Proteins ◽  
Initiation Factor ◽  
Eukaryotic Initiation Factor ◽  
Eukaryotic Initiation Factor 4E

Tissue Distribution, Genomic Structure, and Chromosome Mapping of Mouse and Human Eukaryotic Initiation Factor 4E-Binding Proteins 1 and 2

Genomics ◽  
1996 ◽  
Vol 38 (3) ◽  
pp. 353-363 ◽  
Author(s):  
Kyoko Tsukiyama-Kohara ◽  
Silvia M. Vidal ◽  
Anne-Claude Gingras ◽  
Thomas W. Glover ◽  
Samir M. Hanash ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Binding Proteins ◽  
Genomic Structure ◽  
Chromosome Mapping ◽  
Initiation Factor ◽  
Eukaryotic Initiation Factor ◽  
Eukaryotic Initiation Factor 4E

scholarly journals 4E-binding Proteins, the Suppressors of Eukaryotic Initiation Factor 4E, Are Down-regulated in Cells with Acquired or Intrinsic Resistance to Rapamycin

2002 ◽  
Vol 277 (16) ◽  
pp. 13907-13917 ◽  
Author(s):  
Michael B. Dilling ◽  
Glen S. Germain ◽  
Lorina Dudkin ◽  
Arun L. Jayaraman ◽  
Xiongwen Zhang ◽  
...  
Keyword(s):  
Binding Proteins ◽  
Initiation Factor ◽  
Eukaryotic Initiation Factor ◽  
Intrinsic Resistance ◽  
Eukaryotic Initiation Factor 4E ◽  
In Cells

Contrasting mechanisms of regulating translation of specific Drosophila germline mRNAs at the level of 5′-cap structure binding

2005 ◽  
Vol 33 (6) ◽  
pp. 1544-1546 ◽  
Author(s):  
P. Lasko ◽  
P. Cho ◽  
F. Poulin ◽  
N. Sonenberg
Keyword(s):  
Translational Control ◽  
Binding Proteins ◽  
Regulatory Mechanism ◽  
Ribosomal Subunit ◽  
Drosophila Embryo ◽  
Initiation Factor ◽  
Control Mechanisms ◽  
Eukaryotic Initiation Factor ◽  
Eukaryotic Initiation Factor 4E ◽  
Cognate Protein

Translational control is a key genetic regulatory mechanism underlying the initial establishment of the major spatial axes of the Drosophila embryo. Many translational control mechanisms target eIF4E (eukaryotic initiation factor 4E), an initiation factor that recognizes the 5′-cap structure of the mRNA. Cap recognition by eIF4E, in complex with eIF4G, is essential for recruitment of the mRNA to the small ribosomal subunit. One established mechanism for repressing translation involves eIF4E-binding proteins, which competitively inhibit the eIF4E–eIF4G interaction. Our group has uncovered a novel mechanism for repression in which an eIF4E cognate protein called d4EHP, which cannot bind eIF4G, binds to the 5′-cap structure of cad mRNA thus rendering it translationally inactive. These two related, but distinct, mechanisms are discussed and contrasted in this review.

scholarly journals The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response

2009 ◽  
Vol 296 (5) ◽  
pp. C1207-C1217 ◽  
Author(s):  
R. Sukarieh ◽  
N. Sonenberg ◽  
J. Pelletier
Keyword(s):  
Protein Synthesis ◽  
Binding Proteins ◽  
Initiation Factor ◽  
Eukaryotic Initiation Factor ◽  
Eukaryotic Initiation Factor 4E ◽  
Rate Limiting Step ◽  
Limiting Step ◽  
Repressor Proteins ◽  
Shock Response ◽  
Rate Limiting

Stress granules (SGs) arise as a consequence of cellular stress, contain stalled translation preinitiation complexes, and are associated with cell survival during environmental insults. SGs are dynamic entities with proteins relocating into and out of them during stress. Among the repertoire of proteins present in SGs is eukaryotic initiation factor 4E (eIF4E), a translation factor required for cap-dependent translation and that regulates a rate-limiting step for protein synthesis. Herein, we demonstrate that localization of eIF4E to SGs is dependent on the presence of a family of repressor proteins, eIF4E-binding proteins (4E-BPs). Our results demonstrate that 4E-BPs regulate the SG localization of eIF4E.

scholarly journals Phosphorylation of eukaryotic initiation factor 4E (eIF4E) at Ser209 is not required for protein synthesis in vitro and in vivo

2001 ◽  
Vol 268 (20) ◽  
pp. 5375-5385 ◽  
Author(s):  
Linda McKendrick ◽  
Simon J. Morley ◽  
Virginia M. Pain ◽  
Rosemary Jagus ◽  
Bhavesh Joshi
Keyword(s):  
Protein Synthesis ◽  
Initiation Factor ◽  
Eukaryotic Initiation Factor ◽  
Eukaryotic Initiation Factor 4E

Thermodynamics of Molecular Recognition of mRNA 5′ Cap by Yeast Eukaryotic Initiation Factor 4E

2011 ◽  
Vol 115 (27) ◽  
pp. 8746-8754 ◽  
Author(s):  
Katarzyna Kiraga-Motoszko ◽  
Anna Niedzwiecka ◽  
Anna Modrak-Wojcik ◽  
Janusz Stepinski ◽  
Edward Darzynkiewicz ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
Initiation Factor ◽  
Eukaryotic Initiation Factor ◽  
Eukaryotic Initiation Factor 4E
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