Gingival hyperplasia caused by calcium channel blockers

ABSTRACT Calcium channel blockers are one of the most commonly used drugs for the management of cardiovascular disorders and are known for causing gingival over growth as adverse effects. Now a days, a new drug in this family Amlodipine, is being widely used, because of its duration of action. But it is of concern to the dental practitioner that this drug too has a similar effect on gingival tissues. This paper aims at drawing the attention of dentists towards the adverse effects of amlodipine along with providing a brief review of the pharmacologic profile of this drug, its effects on the gingiva and the management of hyperplasia.

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A Rare Case Report of Amlodipine-Induced Gingival Enlargement and Review of Its Pathogenesis

Case Reports in Dentistry ◽

10.1155/2013/138248 ◽

2013 ◽

Vol 2013 ◽

pp. 1-3 ◽

Cited By ~ 3

Author(s):

Sanjeev Joshi ◽

Sucheta Bansal

Keyword(s):

Calcium Channel ◽

Calcium Channel Blockers ◽

Channel Blocker ◽

Periodontal Diseases ◽

Clinical Feature ◽

Channel Blockers ◽

Gingival Hyperplasia ◽

Unwanted Side Effect ◽

Gingival Enlargement ◽

Rare Case Report

Gingival enlargement is a common clinical feature of gingival and periodontal diseases. It is an unwanted side effect of certain systemic drugs given for nondental treatment. It is being reported with three main groups of drugs like calcium channel blockers (CCBs), immunosuppressants, and anticonvulsants. Among calcium channel blockers, nifedipine causes gingival hyperplasia in about 10% of patients, whereas the incidence of amlodipine-, a third generation calcium channel blocker, induced gingival hyperplasia is very limited. There are very few reports of amlodipine-induced gingival enlargement at a dose of 5 mg. We report a case of amlodipine-induced gingival enlargement in a 45-year-old hypertensive patient taking amlodipine at a dose of 5 mg.

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Amlodipine-Induced Gingival Hyperplasia in a Great Dane

Journal of the American Animal Hospital Association ◽

10.5326/jaaha-ms-5565 ◽

2011 ◽

Vol 47 (5) ◽

pp. 375-376 ◽

Cited By ~ 4

Author(s):

Marlene S. Pariser ◽

Paul Berdoulay

Keyword(s):

Physical Examination ◽

Calcium Channel ◽

Calcium Channel Blockers ◽

Side Effect ◽

Full Recovery ◽

Systemic Hypertension ◽

Channel Blockers ◽

Gingival Hyperplasia ◽

Great Dane

A 3 yr old, 70 kg (154 lbs) female spayed Great Dane developed gingival hyperplasia after treatment of systemic hypertension with amlodipine 7.5 mg q 12 hr for 16 mo. Physical examination was unremarkable except for systemic hypertension and severe gingival hyperplasia. Amlodipine was replaced with hydralazine (0.72 mg/kg [0.32 mg/lb]). Nine months later, gingival hyperplasia was nearly resolved and hypertension was well controlled. Calcium channel blockers such as amlodipine are a rare cause of gingival hyperplasia in the canine patient. Recognition of this side effect is important because a full recovery can be achieved when the offending agent is removed.

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Current Use of Calcium Channel Blockers (CCBs) is Associated with an Increased Risk of Gingival Hyperplasia

Journal of Evidence Based Dental Practice ◽

10.1016/s1532-3382(12)70028-3 ◽

2012 ◽

Vol 12 (3) ◽

pp. 147-148 ◽

Cited By ~ 1

Keyword(s):

Calcium Channel ◽

Calcium Channel Blockers ◽

Channel Blockers ◽

Gingival Hyperplasia ◽

Increased Risk

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Calcium channel blockers-induced gingival hyperplasia

Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology ◽

10.1016/s1079-2104(96)80007-2 ◽

1996 ◽

Vol 81 (4) ◽

pp. 378-379

Author(s):

Abraham Nyska ◽

Dan Dayan

Keyword(s):

Calcium Channel ◽

Calcium Channel Blockers ◽

Channel Blockers ◽

Gingival Hyperplasia

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Laser Therapy In Drug Induced Gingival Hyperplasia- A Case Report

10.51626/ijoh.2021.01.00008 ◽

2021 ◽

Vol 1 (2) ◽

Keyword(s):

Case Report ◽

Calcium Channel ◽

Laser Therapy ◽

Calcium Channel Blockers ◽

Treatment Modalities ◽

Personal Satisfaction ◽

Channel Blockers ◽

Gingival Hyperplasia ◽

Bacterial Burden ◽

Drug Induced

Gingival excess is related with various components including innate infections, hormonal unsettling influences, helpless oral cleanliness condition, aggravation, neoplastic conditions, and unfavorable medication responses including anticonvulsants, calcium channel blockers, and immunosuppressants. This can have an inconvenient impact on the personal satisfaction and furthermore on high oral bacterial burden brought about by plaqueretentive regions. Different treatment modalities incorporate both careful (gingivectomy, periodontal fold, electrosurgery, and laser extraction) and nonsurgical methodologies. This case report reveals the treatment of drug induced gingival hyperplasia with laser

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A rare case of accelerated gingival overgrowth with high dose amlodipine therapy

Journal of Pharmacovigilance and Drug Research ◽

10.53411/jpadr.2021.2.1.8 ◽

2021 ◽

Vol 2 (1) ◽

pp. 39-41

Author(s):

Rakesh B M ◽

Sahithi Sharma ◽

Chandana K H

Keyword(s):

Calcium Channel ◽

Calcium Channel Blockers ◽

Rare Case ◽

Immunosuppressive Drugs ◽

High Dose ◽

Channel Blockers ◽

Gingival Hyperplasia ◽

Limited Evidence ◽

Drug Induced ◽

Gingival Overgrowth

Introduction: Gingival overgrowth represents an over-exuberant response to a variety of local and systemic conditions. Certain anticonvulsants, immunosuppressive drugs, and a number of calcium channel blockers have been shown to produce similar gingival overgrowth in susceptible patients. Case report: We report a case of accelerated drug-induced gingival overgrowth in a 60-year-old hypertensive patient taking amlodipine at a dose of 10 mg. Conclusions: Among the calcium channel blockers, nifedipine is most frequently associated with gingival overgrowth. Whereas, there is limited evidence of amlodipine-induced gingival hyperplasia.

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