scholarly journals A novel inhibitory effect of oxazol-5-one compounds on ROCKII signaling in human coronary artery vascular smooth muscle cells

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Abdulhameed Al-Ghabkari ◽  
Jing-Ti Deng ◽  
Paul C. McDonald ◽  
Shoukat Dedhar ◽  
Mana Alshehri ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Coronary Artery ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Inhibitory Effect ◽  
Human Coronary Artery

K + Currents in Human Coronary Artery Vascular Smooth Muscle Cells

1996 ◽  
Vol 78 (4) ◽  
pp. 676-688 ◽  
Author(s):  
Maik Gollasch ◽  
Christian Ried ◽  
Rostislav Bychkov ◽  
Friedrich C. Luft ◽  
Hermann Haller
Keyword(s):  
Smooth Muscle ◽  
Coronary Artery ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Human Coronary Artery ◽  
K Currents

Different Migration of Vascular Smooth Muscle Cells from Human Coronary Artery Bypass Vessels

2007 ◽  
Vol 44 (2) ◽  
pp. 149-156 ◽  
Author(s):  
Sabine Weiss ◽  
Karin Frischknecht ◽  
Helen Greutert ◽  
Sravan Payeli ◽  
Jan Steffel ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Coronary Artery ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Coronary Artery Bypass ◽  
Vascular Smooth Muscle Cells ◽  
Artery Bypass ◽  
Muscle Cells ◽  
Human Coronary Artery

Mechanics of resting isolated single vascular smooth muscle cells from bovine coronary artery

1984 ◽  
Vol 246 (3) ◽  
pp. C277-C287 ◽  
Author(s):  
A. M. VanDijk ◽  
P. A. Wieringa ◽  
M. van der Meer ◽  
J. D. Laird
Keyword(s):  
Smooth Muscle ◽  
Coronary Artery ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Viscous Resistance ◽  
Resting Cells ◽  
Initial Length ◽  
Arterial Smooth Muscle

The viscoelastic behavior of single resting vascular smooth muscle cells from bovine coronary artery was studied. No maintained passive force could be recorded, even when the cells were stretched to two to four times their initial length; this finding suggests that the smooth muscle cells do not contribute to the parallel elastic component in arterial smooth muscle tissue. The force during stretch of resting arterial cells was proportional to the rate of stretch (which varied between 20 and 60% of the initial length per second). This linear viscous resistance was also found for toad stomach cells when similar stretches were applied. The stress-relaxation curves of the arterial cells could be fitted to the sum of two exponential components (with half-lives of 13.1 and 0.5 s, respectively). As a result of the above findings, a model consisting of two viscoelastic elements in parallel was proposed for a single resting arterial smooth muscle cell. The viscous resistance to stretch of resting cells in a Ca2+-containing solution was not significantly (P greater than 0.01) different from that in a Ca2+-free solution. The same result was obtained for bovine coronary arterial rings. It is concluded that an adequate model for resting arterial smooth muscle should include an intracellular viscous element.

Altered L-type Ca2+ channel currents in vascular smooth muscle cells from experimental diabetic rats

2000 ◽  
Vol 278 (3) ◽  
pp. H714-H722 ◽  
Author(s):  
Rui Wang ◽  
Yuejin Wu ◽  
Guanghua Tang ◽  
Lingyun Wu ◽  
Salma Toma Hanna
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Vascular Complications ◽  
Muscle Cells ◽  
Inhibitory Effect ◽  
Diabetic Rats ◽  
High Concentration ◽  
Voltage Dependent

Vascular complications of diabetes are associated with abnormal Ca2+ handling by vascular smooth muscle cells (SMCs) in which the alteration in L-type voltage-dependent Ca2+ channel (VDCC) currents may play an important role. In the present study, the characteristics of L-type VDCC currents in tail artery SMCs from streptozotocin-induced diabetic rats were examined. The densities, but not the voltage dependence, of L-type VDCC currents were reduced as diabetes progressed from 1 wk to 3 mo. The inhibitory effect of dibutyryl-cAMP on L-type VDCC currents was greater in diabetic SMCs than in age-matched control cells ( P < 0.01). Both the stimulatory effect of BAY K 8644 and the inhibitory effect of nifedipine on L-type VDCC currents were significantly enhanced in diabetic cells. The diabetes-related abnormalities in L-type VDCC currents were mimicked by culturing SMCs with a high concentration of glucose. Our results suggest that the properties of L-type VDCC in diabetic vascular SMCs were significantly altered, partially related to the increased L-type VDCC sensitivity to cAMP and hyperglycemia.

Inhibitory effect of nonsteroidal anti-inflammatory drugs on adenosine transport in vascular smooth muscle cells

2009 ◽  
Vol 612 (1-3) ◽  
pp. 15-20 ◽  
Author(s):  
Rachel Wai-Sum Li ◽  
Sai-Wang Seto ◽  
Alice Lai-Shan Au ◽  
Yiu-Wa Kwan ◽  
Shun-Wan Chan ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Inhibitory Effect ◽  
Adenosine Transport ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals INHIBITORY EFFECT OF REINIOSIDE C ON VASCULAR SMOOTH MUSCLE CELLS PROLIFERATION INDUCED BY ANGIOTENSIN II VIA INHIBITING NADPH OXIDASE-ROS-ERK1/2-NF-KB-AP-1 PATHWAY

Heart ◽  
2012 ◽  
Vol 98 (Suppl 2) ◽  
pp. E120.3-E121
Author(s):  
Dan Hong ◽  
Rui-Zheng Shi ◽  
Yong-Ping Bai ◽  
Chang-Ping Hu ◽  
Gui-Shan Tan ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Vascular Smooth Muscle ◽  
Nadph Oxidase ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Inhibitory Effect
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