scholarly journals Regulation of osteoblast development by Bcl-2-associated athanogene-1 (BAG-1)

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Joanna Greenhough ◽  
Emmanouil S. Papadakis ◽  
Ramsey I. Cutress ◽  
Paul A. Townsend ◽  
Richard O. C. Oreffo ◽  
...  
Keyword(s):  
Osteoblast Development

Osteoclast and Osteoblast Development of Mus musculus Haemopoietic Mononucleated Cells

2008 ◽  
Vol 8 (3) ◽  
pp. 506-516 ◽  
Author(s):  
Z.A. Intan Zari ◽  
Z.A. Shahrul Hi ◽  
M.A.W. Rohaya ◽  
S. Sahidan ◽  
Z.A. Zaidah
Keyword(s):  
Mus Musculus ◽  
Osteoblast Development

Inactivation of NF-κB Involved in Osteoblast Development through Interleukin-6

2001 ◽  
Vol 282 (5) ◽  
pp. 1080-1084 ◽  
Author(s):  
Yoshiaki Deyama ◽  
Sadaaki Takeyama ◽  
Kuniaki Suzuki ◽  
Yoshitaka Yoshimura ◽  
Makoto Nishikata ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Osteoblast Development

scholarly journals Osteopenia, decreased bone formation and impaired osteoblast development in Sox4 heterozygous mice

2007 ◽  
Vol 120 (16) ◽  
pp. 2785-2795 ◽  
Author(s):  
L. S. H. Nissen-Meyer ◽  
R. Jemtland ◽  
V. T. Gautvik ◽  
M. E. Pedersen ◽  
R. Paro ◽  
...  
Keyword(s):  
Bone Formation ◽  
Osteoblast Development

Bcl-2-associated athanogene-1 (BAG-1) regulates chondrocyte and osteoblast development

2016 ◽  
Author(s):  
Joanna Greenhough ◽  
Emmanouil Papadakis ◽  
Ramsey Cutress ◽  
Paul Townsend ◽  
Richard Oreffo ◽  
...  
Keyword(s):  
Osteoblast Development

Changes in IGF-I and -II expression and secretion during the proliferation and differentiation of normal rat osteoblasts

1995 ◽  
Vol 144 (2) ◽  
pp. 251-259 ◽  
Author(s):  
R S Birnbaum ◽  
R R Bowsher ◽  
K M Wiren
Keyword(s):  
Extracellular Matrix ◽  
Physiological Role ◽  
Mrna Levels ◽  
Proliferation And Differentiation ◽  
Igf I ◽  
Igf Binding ◽  
Normal Rat ◽  
Osteoblast Development ◽  
Igf Binding Protein

Abstract IGF-I and -II have potent effects on proliferation and differentiation of osteoblasts in vitro. These cells secrete both IGFs and expression of these peptides is regulated by several of the hormones and growth factors that promote bone resorption and/or formation. However, the physiological role(s) of IGFs in the remodelling process of adult bone is still unclear. Some confusion may arise from results influenced, in part, by differences in the state of osteoblast development of in vitro cultures. Several laboratories have demonstrated that murine osteoblast cultures progress from proliferating preosteoblasts, to mature differentiated osteoblasts that form an extracellular matrix, to cultures that form a mineralized matrix. We have recently documented changes in IGF-binding protein expression and secretion in these cultures. To complement and extend this work, we have examined IGF-I expression and secretion and IGF-II expression during in vitro osteoblast development. Steady-state mRNA levels of both IGF-I and -II increased from the earliest time examined, day 5 in culture, to a maximum at day 11 and, thereafter, declined. IGF-I secreted into the medium also changed in a biphasic manner, but IGF-II could not be quantitated due to the sensitivity of our assay. Secretion of IGF-I was lowest between days 8 and 14. IGF-I secretion on day 5 was significantly greater than day 8. Similarly, IGF-I secretion from day 17 to 26 was also greater than observed for days 8 to 14. If differentiation of the cells was inhibited, this late rise in IGF-I secretion was abolished. We conclude that IGF-I is an autocrine mitogen of the proliferating preosteoblasts. Further, we also suggest that the rise in IGF-I secretion, late in osteoblast development, may lead to sequestration of this mitogen in the extracellular matrix for release during a subsequent remodelling cycle. Journal of Endocrinology (1995) 144, 251–259

Enhanced osteoblast development after continuous infusion of hPTH(1-84) in the rat

Bone ◽  
1999 ◽  
Vol 24 (2) ◽  
pp. 89-94 ◽  
Author(s):  
P.H Watson ◽  
L.J Fraher ◽  
M Kisiel ◽  
D DeSousa ◽  
G Hendy ◽  
...  
Keyword(s):  
Continuous Infusion ◽  
Osteoblast Development

scholarly journals Sequential roles of Hedgehog and Wnt signaling in osteoblast development

Development ◽  
2004 ◽  
Vol 132 (1) ◽  
pp. 49-60 ◽  
Author(s):  
H. Hu
Keyword(s):  
Wnt Signaling ◽  
Osteoblast Development

Abnormal osteoblast development from Nf1 null embryonic stem cells

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S365 ◽  
Author(s):  
Xijie Yu ◽  
Junrong Ma ◽  
Meng Gong ◽  
Ryan Guillemette ◽  
Janet Hock
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Osteoblast Development
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