scholarly journals A humanized mouse model for sequestration of Plasmodium falciparum sexual stages and in vivo evaluation of gametocytidal drugs

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Yoann Duffier ◽  
Audrey Lorthiois ◽  
Pau Cisteró ◽  
Florian Dupuy ◽  
Grégory Jouvion ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Mouse Model ◽  
Humanized Mouse ◽  
Humanized Mouse Model ◽  
In Vivo Evaluation ◽  
Sexual Stages

scholarly journals Humanized Mouse Model Mimicking Pathology of Human Tuberculosis for in vivo Evaluation of Drug Regimens

2019 ◽  
Vol 10 ◽  
Author(s):  
Frida Arrey ◽  
Delia Löwe ◽  
Stefanie Kuhlmann ◽  
Peggy Kaiser ◽  
Pedro Moura-Alves ◽  
...  
Keyword(s):  
Mouse Model ◽  
Humanized Mouse ◽  
Humanized Mouse Model ◽  
In Vivo Evaluation ◽  
Drug Regimens

Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria

2018 ◽  
Vol 61 (13) ◽  
pp. 5692-5703 ◽  
Author(s):  
Nishanth Kandepedu ◽  
Diego Gonzàlez Cabrera ◽  
Srinivas Eedubilli ◽  
Dale Taylor ◽  
Christel Brunschwig ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Mouse Model ◽  
Kinase Inhibitors ◽  
Humanized Mouse ◽  
Humanized Mouse Model ◽  
In Vivo Efficacy ◽  
Phosphatidylinositol 4

scholarly journals P06.07 In vivo studies of immunomodulatory a-CTLA-4 antibody in a humanized mouse model

2021 ◽  
Vol 9 (Suppl 1) ◽  
pp. A22.1-A22
Author(s):  
C Reitinger ◽  
F Nimmerjahn
Keyword(s):  
Immune System ◽  
Mouse Model ◽  
Cancer Immunotherapy ◽  
Model Systems ◽  
Checkpoint Control ◽  
Human Immune System ◽  
Humanized Mouse ◽  
Humanized Mouse Model ◽  
Human Immune

BackgroundRecent findings in cancer immunotherapy have reinforced the hypothesis that the immune system is able to control most cancers. Immunomodulatory antibodies can enhance immune responses, having the potential to generate anti-cancer immunity.1–4Materials and MethodsMost current studies addressing this question are performed in murine mouse model systems or use in vitro culture systems, which do not reflect the human in vivo situation, potentially leading to results that cannot be fully translated into human cancer therapy. Therefore, it is necessary to establish a new mouse model, which allows the study of cancer immunotherapy in the context of a human immune system. We focused on the establishment of a humanized mouse model, in which different immunomodulatory antibodies can be tested in the presence of a human immune system.ResultsFirst experiments concerning the suitability to test immunomodulatory antibodies in the humanized mouse model, revealed that effects of checkpoint-control antibody a-CTLA-4 were similar to the effects seen in patients of clinical studies. To analyse the anti-tumor activities of immunomodulatory antibodies in vivo we are establishing a human melanoma-like tumor model in humanized mice.ConclusionsThis enables us to test the efficacy of immunomodulatory agonistic antibodies (such as CP-870,893) and checkpoint control antibodies (such as anti-CTLA-4) in eliminating a melanoma-like tumor. Furthermore, parameters like tumor infiltrating human cells und cytokine/chemokine production can be analysed.ReferencesSchuster M, Nechansky A, Loibner H. Cancer immunotherapy. Biotechnol J 2006;1:138–147.Mellman I, Coukos G, Dranoff G. Cancer immunotherapy comes of age. Nature rev 2011;480:480–489.Finn OJ. Immuno-oncology: understanding the function and dysfunction of the immune system in cancer. Annals of Oncology 2012;23:vii6–vii9.Langer LF, Clay TM, Morse MA. Update on anti-CTLA-4 in clinical trials. Expert Opin Biol Ther 2007;8:1245–1256.Disclosure InformationC. Reitinger: None. F. Nimmerjahn: None.

In Vivo Gene Delivery into hCD34+ Cells in a Humanized Mouse Model

2011 ◽  
pp. 367-390 ◽  
Author(s):  
Cecilia Frecha ◽  
Floriane Fusil ◽  
François-Loïc Cosset ◽  
Els Verhoeyen
Keyword(s):  
Gene Delivery ◽  
Mouse Model ◽  
Humanized Mouse ◽  
Humanized Mouse Model ◽  
In Vivo Gene Delivery

scholarly journals A novel humanized mouse model to study the function of human cutaneous memory T cells in vivo in human skin

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Maria M. Klicznik ◽  
Ariane Benedetti ◽  
Laura M. Gail ◽  
Suraj R. Varkhande ◽  
Raimund Holly ◽  
...  
Keyword(s):  
T Cells ◽  
Mouse Model ◽  
Human Skin ◽  
Memory T Cells ◽  
Humanized Mouse ◽  
Humanized Mouse Model

In Vivo Anti-MicroRNA Treatment in a Humanized Mouse Model for Allograft Vasculopathy

2017 ◽  
Vol 36 (4) ◽  
pp. S446
Author(s):  
M. Huibers ◽  
L. Qin ◽  
G. Li ◽  
J. Renes ◽  
C. Venema ◽  
...  
Keyword(s):  
Mouse Model ◽  
Humanized Mouse ◽  
Humanized Mouse Model ◽  
Allograft Vasculopathy

scholarly journals Human anti-CAIX antibodies mediate immune cell inhibition of renal cell carcinoma in vitro and in a humanized mouse model in vivo

2015 ◽  
Vol 14 (1) ◽  
Author(s):  
De-Kuan Chang ◽  
Raymond J. Moniz ◽  
Zhongyao Xu ◽  
Jiusong Sun ◽  
Sabina Signoretti ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Mouse Model ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Immune Cell ◽  
Humanized Mouse ◽  
Humanized Mouse Model ◽  
Cell Inhibition

scholarly journals Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD-scid IL2Rγnull Mouse Model of Malaria

2018 ◽  
Vol 63 (3) ◽  
Author(s):  
Paul R. Gilson ◽  
William Nguyen ◽  
William A. Poole ◽  
Jose E. Teixeira ◽  
Jennifer K. Thompson ◽  
...  
Keyword(s):  
Mouse Model ◽  
Babesia Bovis ◽  
Parasite Line ◽  
Humanized Mouse ◽  
Humanized Mouse Model ◽  
Content Type ◽  
Apicomplexan Parasites ◽  
Micromolar Range

ABSTRACT A series of 4-amino 2-anilinoquinazolines optimized for activity against the most lethal malaria parasite of humans, Plasmodium falciparum, was evaluated for activity against other human Plasmodium parasites and related apicomplexans that infect humans and animals. Four of the most promising compounds from the 4-amino 2-anilinoquinazoline series were equally as effective against the asexual blood stages of the zoonotic P. knowlesi, suggesting that they could also be effective against the closely related P. vivax, another important human pathogen. The 2-anilinoquinazoline compounds were also potent against an array of P. falciparum parasites resistant to clinically available antimalarial compounds, although slightly less so than against the drug-sensitive 3D7 parasite line. The apicomplexan parasites Toxoplasma gondii, Babesia bovis, and Cryptosporidium parvum were less sensitive to the 2-anilinoquinazoline series with a 50% effective concentration generally in the low micromolar range, suggesting that the yet to be discovered target of these compounds is absent or highly divergent in non-Plasmodium parasites. The 2-anilinoquinazoline compounds act as rapidly as chloroquine in vitro and when tested in rodents displayed a half-life that contributed to the compound’s capacity to clear P. falciparum blood stages in a humanized mouse model. At a dose of 50 mg/kg of body weight, adverse effects to the humanized mice were noted, and evaluation against a panel of experimental high-risk off targets indicated some potential off-target activity. Further optimization of the 2-anilinoquinazoline antimalarial class will concentrate on improving in vivo efficacy and addressing adverse risk.

scholarly journals RARE-01. IN VIVO IMMUNOMODULATING EFFECT OF LXR-623 AND ITS SYNERGISM WITH CHECKPOINT BLOCKADE AGAINST CHORDOMAS IN A HUMANIZED MOUSE MODEL

2018 ◽  
Vol 20 (suppl_6) ◽  
pp. vi236-vi236
Author(s):  
Wataru Ishida ◽  
Riccardo Serra ◽  
Noah Gorelick ◽  
Yuanxuan Xia ◽  
Joshua Casaos ◽  
...  
Keyword(s):  
Mouse Model ◽  
Checkpoint Blockade ◽  
Immunomodulating Effect ◽  
Humanized Mouse ◽  
Humanized Mouse Model
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