scholarly journals LUC7L3/CROP inhibits replication of hepatitis B virus via suppressing enhancer II/basal core promoter activity

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Yuan Li ◽  
Masahiko Ito ◽  
Suofeng Sun ◽  
Takeshi Chida ◽  
Kenji Nakashima ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Promoter Activity ◽  
Core Promoter ◽  
Basal Core Promoter ◽  
B Virus ◽  
Enhancer Ii ◽  
Core Promoter Activity

scholarly journals Transactivation of the Hepatitis B Virus Core Promoter by the Nuclear Receptor FXRα

2008 ◽  
Vol 82 (21) ◽  
pp. 10832-10840 ◽  
Author(s):  
Christophe Ramière ◽  
Caroline Scholtès ◽  
Olivier Diaz ◽  
Vinca Icard ◽  
Laure Perrin-Cocon ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Bile Acids ◽  
Nuclear Receptor ◽  
Promoter Activity ◽  
Core Promoter ◽  
Response Elements ◽  
B Virus ◽  
Enhancer Ii ◽  
Core Promoter Activity

ABSTRACT Hepatitis B virus (HBV) core promoter activity is positively and negatively regulated by nuclear receptors, a superfamily of ligand-activated transcription factors, via cis-acting sequences located in the viral genome. In this study, we investigated the role of farnesoid X receptor alpha (FXRα) in modulating transcription from the HBV core promoter. FXRα is a liver-enriched nuclear receptor activated by bile acids recognizing hormone response elements by forming heterodimers with retinoid X receptor alpha (RXRα). Electrophoretic mobility shift assays demonstrated that FXRα-RXRα heterodimers can bind two motifs on the HBV enhancer II and core promoter regions, presenting high homology to the consensus (AGGTCA) inverted repeat FXRα response elements. In transient transfection of the human hepatoma cell line Huh-7, bile acids enhanced the activity of a luciferase reporter containing the HBV enhancer II and core promoter sequences through FXRα. Moreover, using a greater-than-genome-length HBV construct, we showed that FXRα also increased synthesis of the viral pregenomic RNA and DNA replication intermediates. The data strongly suggest that FXRα is another member of the nuclear receptor superfamily implicated in the regulation of HBV core promoter activity and that bile acids could play an important role in the natural history of HBV infection.

Effect of combined mutations in the enhancer II and basal core promoter of hepatitis B virus on development of hepatocellular carcinoma in Qidong, China

2014 ◽  
Vol 44 (12) ◽  
pp. 1186-1195 ◽  
Author(s):  
Li-Shuai Qu ◽  
Jing Zhu ◽  
Tao-Tao Liu ◽  
Xi-Zhong Shen ◽  
Tao-Yang Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Core Promoter ◽  
Basal Core Promoter ◽  
B Virus ◽  
Enhancer Ii

scholarly journals Prevalence of Hepatitis B Virus Subgenotypes and Basal Core Promoter, Precore Variants in Patients with Acute Hepatitis B in Central Vietnam

Intervirology ◽  
2009 ◽  
Vol 52 (1) ◽  
pp. 22-28 ◽  
Author(s):  
Kazuhiko Hayashi ◽  
Yoshiaki Katano ◽  
Tran Xuan Chuong ◽  
Yasushi Takeda ◽  
Masatoshi Ishigami ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
Core Promoter ◽  
Basal Core Promoter ◽  
Central Vietnam ◽  
B Virus ◽  
Acute Hepatitis B

Precore and basal core promoter hepatitis B virus (HBV) variants are present from a young age and differ across HBV genotypes

Hepatology ◽  
2020 ◽  
Author(s):  
Daryl T.Y. Lau ◽  
Lilia Ganova‐Raeva ◽  
Junyao Wang ◽  
Douglas Mogul ◽  
Raymond T. Chung ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Core Promoter ◽  
Young Age ◽  
Basal Core Promoter ◽  
Hbv Genotypes ◽  
B Virus ◽  
Hbv Variants

T1762/A1764variants of the basal core promoter of hepatitis B virus; serological and clinical correlations in Chinese patients

1999 ◽  
Vol 19 (5) ◽  
pp. 411-417 ◽  
Author(s):  
Jinlin Hou ◽  
George K. K. Lau ◽  
Jinjun Cheng ◽  
Chi Chung Cheng ◽  
Kangxian Luo ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Core Promoter ◽  
Chinese Patients ◽  
Basal Core Promoter ◽  
B Virus ◽  
Clinical Correlations

Clinical features and prognosis of hepatocellular carcinoma with respect to pre-S deletion and basal core promoter mutations of hepatitis B virus Genotype C2

2011 ◽  
Vol 83 (12) ◽  
pp. 2088-2095 ◽  
Author(s):  
Han Jak Ryu ◽  
Do Young Kim ◽  
Jun Yong Park ◽  
Hye Young Chang ◽  
Myoung Ha Lee ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Clinical Features ◽  
Core Promoter ◽  
Basal Core Promoter ◽  
Virus Genotype ◽  
B Virus ◽  
Promoter Mutations

scholarly journals The incidence rate over 10years of naturally occurring, cancer related mutations in the basal core promoter of hepatitis B virus

2015 ◽  
Vol 34 ◽  
pp. 75-80
Author(s):  
Xue-Yan Wang ◽  
Tim J. Harrison ◽  
Qin-Yan Chen ◽  
Hai Li ◽  
Guo-Jian Li ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Incidence Rate ◽  
Core Promoter ◽  
Basal Core Promoter ◽  
Naturally Occurring ◽  
B Virus
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