scholarly journals Developmental disruption of perineuronal nets in the medial prefrontal cortex after maternal immune activation

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
John W. Paylor ◽  
Brittney R. Lins ◽  
Quentin Greba ◽  
Nicholas Moen ◽  
Reiner Silveira de Moraes ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Immune Activation ◽  
Perineuronal Nets ◽  
Maternal Immune Activation

Reduction of dopmamine D2 receptor binding in medial prefrontal cortex in schizophrenia animal model with maternal immune activation

2010 ◽  
Vol 68 ◽  
pp. e201
Author(s):  
Arata Oh-Nishi ◽  
Yuji Nagai ◽  
Tetsuya Suhara ◽  
Shigeru Obayashi
Keyword(s):  
Animal Model ◽  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Receptor Binding ◽  
Immune Activation ◽  
D2 Receptor ◽  
Maternal Immune Activation

The development of perineuronal nets around parvalbumin gabaergic neurons in the medial prefrontal cortex and basolateral amygdala of rats.

2017 ◽  
Vol 131 (4) ◽  
pp. 289-303 ◽  
Author(s):  
Kathryn D. Baker ◽  
Arielle R. Gray ◽  
Rick Richardson
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Basolateral Amygdala ◽  
Gabaergic Neurons ◽  
Perineuronal Nets

scholarly journals Diurnal changes in perineuronal nets and parvalbumin neurons in the rat medial prefrontal cortex

2021 ◽  
Author(s):  
John H. Harkness ◽  
Angela E. Gonzalez ◽  
Priyanka N. Bushana ◽  
Emily T. Jorgensen ◽  
Deborah M. Hegarty ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Perineuronal Nets ◽  
Diurnal Changes ◽  
Parvalbumin Neurons

scholarly journals Diurnal changes in perineuronal nets and parvalbumin neurons in the rat medial prefrontal cortex

2020 ◽  
Author(s):  
John H. Harkness ◽  
Angela E. Gonzalez ◽  
Priyanka N. Bushana ◽  
Emily T. Jorgensen ◽  
Deborah M. Hegarty ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Active Phase ◽  
Autism Spectrum ◽  
Diurnal Rhythms ◽  
Oxidative Stress Marker ◽  
Perineuronal Nets ◽  
Diurnal Changes ◽  
Strong Trend ◽  
Fast Spiking

ABSTRACTPerineuronal nets (PNNs) surrounding fast-spiking, parvalbumin (PV) inhibitory interneurons are vital for providing excitatory:inhibitory balance within cortical circuits, and this balance is impaired in disorders such as schizophrenia, autism spectrum disorder, and substance use disorders. These disorders are also associated with altered diurnal rhythms, yet few studies have examined the diurnal rhythms of PNNs or PV cells. We measured the intensity and number of PV cells and PNNs labeled with Wisteria floribunda agglutinin (WFA) in the rat prelimbic medial prefrontal cortex (mPFC) at Zeitgeber times (ZT) ZT0, 6, 12, and 18. We also measured the oxidative stress marker 8-oxo-deoxyguanosine (8-oxo-dG). Relative to ZT0, the intensities of PNN and PV staining were increased in the dark (active) phase compared with the light (inactive) phase. The intensity of 8-oxo-dG was decreased from ZT0 at all time points (ZT6,12,18), in both PV cells and non-PV cells. To examine corresponding changes in inhibitory and excitatory inputs, we measured GAD 65/67 and vGlut1 puncta apposed to PV cells with and without PNNs. Relative to ZT6, there were more excitatory puncta on PV cells surrounded by PNNs at ZT18, but no changes in PV cells devoid of PNNs. No changes in inhibitory puncta were observed. Whole-cell slice recordings in fast-spiking (PV) cells with PNNs showed an increased ratio of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor:N-methyl-D-aspartate receptor (AMPA:NMDA) at ZT18 vs. ZT6. The number of PV cells and co-labeled PV/PNN cells containing the transcription factor orthodenticle homeobox 2 (OTX2), which maintains PNNs, showed a strong trend toward an increase from ZT6 to ZT18. These diurnal fluctuations in PNNs and PV cells are expected to alter cortical excitatory:inhibitory balance and provide new insights into treatment approaches for diseases impacted by imbalances in sleep and circadian rhythms.

scholarly journals Maternal immune activation induces GAD1 and GAD2 promoter remodeling in the offspring prefrontal cortex

Epigenetics ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. 1143-1155 ◽  
Author(s):  
Marie Anaïs Labouesse ◽  
Erbo Dong ◽  
Dennis Robert Grayson ◽  
Alessandro Guidotti ◽  
Urs Meyer
Keyword(s):  
Prefrontal Cortex ◽  
Immune Activation ◽  
Maternal Immune Activation

scholarly journals Removal of Perineuronal Nets in the Medial Prefrontal Cortex Impairs the Acquisition and Reconsolidation of a Cocaine-Induced Conditioned Place Preference Memory

2015 ◽  
Vol 35 (10) ◽  
pp. 4190-4202 ◽  
Author(s):  
M. Slaker ◽  
L. Churchill ◽  
R. P. Todd ◽  
J. M. Blacktop ◽  
D. G. Zuloaga ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Conditioned Place Preference ◽  
Medial Prefrontal Cortex ◽  
Place Preference ◽  
Perineuronal Nets
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