Aspartic protease inhibitors as drug candidates for treating various difficult-to-treat diseases

2014 ◽  
pp. 114-147 ◽  
Author(s):  
Yoshio Hamada ◽  
Yoshiaki Kiso
Keyword(s):  
Protease Inhibitors ◽  
Aspartic Protease ◽  
Drug Candidates

Synthesis ofexo-3-Amino-7-azabicyclo[2.2.1]heptanes as a Class of Malarial Aspartic Protease Inhibitors: Exploration of Two Binding Pockets

2009 ◽  
Vol 2009 (11) ◽  
pp. 1707-1719 ◽  
Author(s):  
Martina Zürcher ◽  
Fraser Hof ◽  
Luzi Barandun ◽  
Andri Schütz ◽  
W. Bernd Schweizer ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Aspartic Protease ◽  
Binding Pockets

Aspartic Protease Inhibitors Designed from Computer-Generated Templates Bind As Predicted

2001 ◽  
Vol 3 (15) ◽  
pp. 2309-2312 ◽  
Author(s):  
Amy S Ripka ◽  
Kenneth A. Satyshur ◽  
Regine S. Bohacek ◽  
Daniel H. Rich
Keyword(s):  
Protease Inhibitors ◽  
Aspartic Protease

Identification of acridinyl hydrazides as potent aspartic protease inhibitors

2008 ◽  
Vol 18 (9) ◽  
pp. 3011-3015 ◽  
Author(s):  
M. Kamran Azim ◽  
Waseem Ahmed ◽  
Ishtiaq A. Khan ◽  
Nosheen A. Rao ◽  
Khalid M. Khan
Keyword(s):  
Protease Inhibitors ◽  
Aspartic Protease

Design and Synthesis of Novel [60]Fullerene Derivatives as Potential HIV Aspartic Protease Inhibitors

2000 ◽  
Vol 2 (25) ◽  
pp. 3955-3958 ◽  
Author(s):  
Gian Luca Marcorin ◽  
Tatiana Da Ros ◽  
Sabrina Castellano ◽  
Giorgio Stefancich ◽  
Irena Bonin ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Aspartic Protease ◽  
Fullerene Derivatives ◽  
Design And Synthesis

Characterisation of hydrazides and hydrazine derivatives as novel aspartic protease inhibitors

2010 ◽  
Vol 25 (5) ◽  
pp. 673-678 ◽  
Author(s):  
Waseem Ahmed ◽  
Mubeen Rani ◽  
Ishtiaq A. Khan ◽  
Asif Iqbal ◽  
Khalid M. Khan ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Aspartic Protease ◽  
Hydrazine Derivatives

scholarly journals Probing the Pharmacological Binding Properties, and Reactivity of Selective Phytochemicals as Potential HIV-1 protease Inhibitors

2019 ◽  
Vol 24 (3) ◽  
pp. 441-464 ◽  
Author(s):  
Ammara Akhtar ◽  
Waqar Hussain ◽  
Nouman Rasool
Keyword(s):  
Viral Replication ◽  
Protease Inhibitors ◽  
Binding Affinity ◽  
Essential Role ◽  
Replication Cycle ◽  
Binding Properties ◽  
Drug Candidates ◽  
Inhibitory Potential ◽  
Potential Inhibitors ◽  
Hiv 1

The HIV-1 protease plays an essential role in the replication cycle of HIV-1; therefore there is a direct need to develop novel inhibitors of the HIV-1 protease, which can cease the viral replication. The present study targets the discovery of potential inhibitors of HIV-1 protease from a set of phytochemicals. From 2505 phytochemicals, 108 compounds were docked, after screening, with the HIV-1 protease to analyze their inhibitory potential against the protease. DFT analysis was also conducted to study the reactivity of strongly docked compounds. Out of 108 phytochemicals, 38 compounds showed binding affinity greater than the desired threshold. Reactivity of these 38 inhibitors was also high as compared to other compounds, based on the DFT results. These results suggest that the selected 38 phytochemicals are drug candidates and they have the potential to be effectively used against HIV in the future.

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