Functionalized carbon nanomaterials as nanocarriers for loading and delivery of a poorly water-soluble anticancer drug: a comparative study

2011 ◽  
Vol 47 (18) ◽  
pp. 5235 ◽  
Author(s):  
Nanda Gopal Sahoo ◽  
Hongqian Bao ◽  
Yongzheng Pan ◽  
Mintu Pal ◽  
Mitali Kakran ◽  
...  
Keyword(s):  
Comparative Study ◽  
Anticancer Drug ◽  
Carbon Nanomaterials ◽  
Water Soluble ◽  
Poorly Water Soluble

Strategies to Maximize Liposomal Drug Loading for a Poorly Water-soluble Anticancer Drug

2014 ◽  
Vol 32 (4) ◽  
pp. 1451-1461 ◽  
Author(s):  
Wenli Zhang ◽  
Guangji Wang ◽  
James R. Falconer ◽  
Bruce C. Baguley ◽  
John P. Shaw ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Drug Loading ◽  
Water Soluble ◽  
Liposomal Drug ◽  
Poorly Water Soluble

Enhancing the solubility and bioactivity of anticancer drug tamoxifen by water-soluble pillar[6]arene-based host–guest complexation

2017 ◽  
Vol 53 (70) ◽  
pp. 9749-9752 ◽  
Author(s):  
Liqing Shangguan ◽  
Qi Chen ◽  
Bingbing Shi ◽  
Feihe Huang
Keyword(s):  
Anticancer Drug ◽  
Water Soluble ◽  
Poorly Water Soluble

A water-soluble pillar[6]arene functions as a solubilizing agent to enhance the solubility and bioactivity of poorly water-soluble anticancer drug tamoxifen.

Methoxy polyethylene glycol–cholesterol modified soy lecithin liposomes for poorly water‐soluble anticancer drug delivery

2020 ◽  
Vol 138 (7) ◽  
pp. 49858
Author(s):  
Ngoc Thuy Trang Le ◽  
Dinh Tien Dung Nguyen ◽  
Ngoc Hoi Nguyen ◽  
Cuu Khoa Nguyen ◽  
Dai Hai Nguyen
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Anticancer Drug ◽  
Water Soluble ◽  
Soy Lecithin ◽  
Anticancer Drug Delivery ◽  
Poorly Water Soluble ◽  
Methoxy Polyethylene Glycol

Non-ionic dendritic glycerol-based amphiphiles: Novel excipients for the solubilization of poorly water-soluble anticancer drug Sagopilone

2010 ◽  
Vol 40 (1) ◽  
pp. 48-55 ◽  
Author(s):  
Annett Richter ◽  
Achim Wiedekind ◽  
Michael Krause ◽  
Thomas Kissel ◽  
Rainer Haag ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Water Soluble ◽  
Poorly Water Soluble

Stable Colloids of Paclitaxel Nanoparticles Coated with PEGylated Polyelectrolyte Shells

2012 ◽  
Vol 1416 ◽  
Author(s):  
Tatsiana G. Shutava ◽  
Kirill A. Arapov ◽  
Pravin P. Pattekari ◽  
Yuri M. Lvov ◽  
Tatyana S. Levchenko ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Intravenous Administration ◽  
Water Soluble ◽  
Layer By Layer ◽  
Lbl Assembly ◽  
Nano Crystalline ◽  
Solid Crystal ◽  
Poorly Water Soluble ◽  
Thick Shells

ABSTRACTA novel nanoparticulated form of the poorly water-soluble anticancer drug paclitaxel (PTX) suitable for intravenous administration has been developed using sonication-assisted layer-by-layer (LbL) assembly. The nanoparticles contain up to 70 wt.% of the drug and consist of 150-180 nm solid crystal paclitaxel cores coated with 20-30 nm thick shells of alternative layers of PEGylated poly-L-lysine and heparin. Dispersions of PTX nanoparticles are stable in different biological solvents at concentrations up to 5 mg/ml. Intravenous administration of the LbL-coated nano-crystalline PTX to mice via tail injection provided the preliminary confirmation of their safety and tolerability.

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