Functionalized graphene oxides for drug loading, release and delivery of poorly water soluble anticancer drug: A comparative study

Application of mixed solvency has been employed in the present research work to develop a liquisolid system (Powder formulation) of poorly water soluble drug, cefixime (as model drug). Material and Methods: For poorly water soluble drug cefixime, combination of solubilizers such as sodium acetate, sodium caprylate and propylene glycol as mixed solvent systems were used to decrease the overall concentration of solubilizers required to produce substantial increase in solubility and thereby resulting in enhanced drug loading capacity of cefixime. The procured sample of cefixime was characterized by melting point, IR, UV and DSC studies. Stability studies of liquisolid system of cefixime were performed for two months at room temperature, 30˚C and 40˚C. All the formulations were physically, chemically, and microbiologically stable. Conclusion: Mixed solvency concept has been successfully employed for enhancing the drug loading of poorly water soluble drug, cefixime. Keywords: Solubility, cefixime, liquisolid system, mixed solvency concept.

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Cyclodextrin Based Nanoparticles for Drug Delivery and Theranostics

Advanced Pharmaceutical Bulletin ◽

10.34172/apb.2020.022 ◽

2020 ◽

Vol 10 (2) ◽

pp. 166-183 ◽

Cited By ~ 8

Author(s):

Dipak Dilip Gadade ◽

Sanjay Sudhakar Pekamwar

Keyword(s):

Drug Delivery ◽

Targeted Drug Delivery ◽

Drug Loading ◽

Water Soluble ◽

Poorly Water Soluble Drugs ◽

Solubility Profile ◽

Water Soluble Drugs ◽

Poorly Water Soluble ◽

Treatment Procedures ◽

Consequent Improvement

Colloidal nanoparticulate technology has been described in the literature as a versatile drug delivery system. But it possesses some inherent lacunae in their formulation. Cyclodextrins (CDs) have been extensively reported for the solubility enhancement of poorly water-soluble drugs. The CDs can cause intervention in aspects related to nanoparticles (NPs) that include improving drug loading in nano-system, improving stability, site-specific/targeted drug delivery, improving solubility profile and absorption of the drug in nanosystem with consequent improvement in bioavailability, with the possibility of controlled release, safety and efficacy. They find application in for simultaneous diagnosis and therapeutics for better treatment procedures. The current communication is focused on the application of CDs to overcome troubles in nanoparticulate formulation and enhancement of their performance. It also envisages the theranostic aspects of CDs.

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Enhancing the solubility and bioactivity of anticancer drug tamoxifen by water-soluble pillar[6]arene-based host–guest complexation

Chemical Communications ◽

10.1039/c7cc05305c ◽

2017 ◽

Vol 53 (70) ◽

pp. 9749-9752 ◽

Cited By ~ 26

Author(s):

Liqing Shangguan ◽

Qi Chen ◽

Bingbing Shi ◽

Feihe Huang

Keyword(s):

Anticancer Drug ◽

Water Soluble ◽

Poorly Water Soluble

A water-soluble pillar[6]arene functions as a solubilizing agent to enhance the solubility and bioactivity of poorly water-soluble anticancer drug tamoxifen.

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