Microstructure and Mechanical Properties of Inverse Nanocomposite Made from Polylactide and Hydroxyapatite Nanoparticles

Polymer nanocomposites have been extensively researched for a variety of applications, including medical osteoregenerative implants. However, no satisfactory solution has yet been found for regeneration of big, and so-called critical, bone losses. The requirement is to create a resorbable material which is characterised by optimum porosity, sufficient strength, and elastic modulus matching that of the bone, thus stimulating tissue regrowth. Inverse nanocomposites, where the ceramic content is larger than the polymer content, are a recent development. Due to their high ceramic content, they may offer the required properties for bone implants, currently not met by polymer nanocomposites with a small number of nanoparticles. This paper presents inverse nanocomposites composed of bioresorbable nano crystalline hydroxyapatite (HAP NPs) and polylactide (PLLA), produced by cryomilling and a warm isostatic pressing method. The following compositions were studied: 25%, 50%, and 75% of HAP NPs by volume. The mechanical properties and structure of these composites were examined. It was discovered that 50% volume content was optimal as far as compressive strength and porosity are concerned. The inverse nanocomposite with 50% nanoceramics volume displayed a compressive strength of 99 ± 4 MPa, a contact angle of 50°, and 25% porosity, which make this material a candidate for further studies as a bioresorbable bone implant.

Studies on nanocomposites nanoplates and pervoskite nanorod thin films

Nano crystalline nickel oxide thin films of different film thickness were deposited onto glass substrate at 350 oC by varying volume of precursor solution using spray pyrolysis technique. This structural, morphological and microstructure properties were investigated using XRD, FE-SEM and TEM. The element composition was studied using EDAX. It is found that increase in the volume of sprayed solution leads to the increment in film thickness and amelioration of crystallinity of the film. The results are discussed and interpreted.

The Impact of Nano-Crystal Hydroxyapatites on the Regeneration of Bone Defects

Calcium hydroxyapatite is a widely used material for replacing bone defects. However, the effectiveness of nano-crystalline calcium hydroxyapatite produced from eggshells in the replacement of bone defects has not been investigated yet. The study aimed to evaluate the effectiveness of using nano-crystalline calcium hydroxyapatite made from eggshell for the healing of bone defect of the femur in rats. Forty-eight (n=48) rats underwent a surgical procedure to simulate femoral defect. The animals were sub-divided into 4 groups (each with n=12) depending on the methods of bone defect replacement: I control group (CG) (without bone defect replacement); II intervention group (the bone defect was replaced by PRP (PRP); III intervention group (the bone defect was replaced by nano-crystalline hydroxyapatite obtained from eggshell) (HA) and IV interventional group (the bone defect was replaced by a combination of hydroxyapatite and PRP) (HA+PRP). The degree of effectiveness of studied methods was assessed using radiological (on the 14th day), histological (on the 61st day), and biomechanical analysis (on the 61st day). According to radiographic data, the CG group had the lowest level of bone regeneration after 14 days (4.2 ±1.7%). In the HA + PRP group, the level of bone regeneration was 22.1±7.1 %, which was higher in comparison with the rates of consolidation of bone defects in the HA group (20.7± 9.3) (p = 0.023). According to the histo-morphometry data, the rates of bone tissue regeneration in the PRP group (19.8 ±4.2%) were higher in comparison with the CG group (12.7 ± 7.3%), (p>0.05). In the HA+PRP group, bone regeneration rates (48.9±9.4 %) were significantly higher (p=0.001) than in the HA group (35.1±9.8%). According to the results of biomechanical assessment under the maximum stress (121.0722), the maximum bending deformation of the contralateral bone without defect was 0.028746, which was higher than the indicators of the HA+PRP group, where at the maximum stress (90.67979) the bending deformation was 0.024953 (p>0.05). Compared to CG, PRP, and HA, biomechanical bone strength was significantly higher in the HA + PRP group (p≤0.01). At the maximum stress (51.81391), the maximum bending strain in the CG group was 0.03869, which was lower than in the PRP group, where the maximum stress and bending strain were 59.45824 and 0.055171, respectively (p>0.05). However, the bone strength of the HA group was statistically significantly higher compared to the CG and PRP groups (p<0.01). The results demonstrated the effectiveness of the use of nanocrystalline calcium hydroxyapatite obtained from eggshell in the healing of a bone defect. The best results were observed in the group of the combined use of nano-crystalline calcium hydroxyapatite and PRP.

Raman area- and thermal- mapping studies of faceted nano-crystalline α-Fe2O3 thin films deposited by spray pyrolysis

Different advanced techniques including Raman area mapping and Raman thermal imaging has been used to investigate various properties of large area iron oxide thin films deposited by spray pyrolysis, on a large area of crystalline silicon substrates under controlled external parameters. Morphological studies reveal that the obtained films acquire lateral faceted crystalline structure of iron oxide. The Raman and SEM images, in unison, confirm the presence and large area distribution of the nano crystals of Fe2O3 phase. Thermal Raman imaging reveals that the obtained iron oxide thin films are robust and thus can be used for appropriate technological applications like electromagnetic shielding.

Quantum-mechanical model of dielectric losses in nanometer layers of solid dielectrics with hydrogen bonds at ultra-low temperatures

Upon based the finite difference methods construct the solutions for Liouville quantum kinetic equation linearized by the external field, in complex with the stationary Schrodinger equation and the Poisson operator equation, for an ensemble of non-interacting hydrogen ions (protons) migrating in the field of a crystal lattice perturbed by a variable polarizing field. The influence of the phonon subsystem is not taken into account. The equilibrium (non-balanced) proton density matrix is calculated using quantum Boltzmann statistics. The temperature spectra of dielectric losses tangent angle for hydrogen bonded crystals (HBC) in a wide temperature range (50–550 K) are calculated. At the theoretical level detected the effects of nano-crystalline states (1–10 nm) during the polarization of HBC in the region of ultra-low temperatures (4–25 K).